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I Like to Draw Pictures of Random Molecules

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polymath said:
9.gif


You mean this?

I can't find any info about 2-benzylpyrrolidine (the compound above), but the structurally similar 2-benzylpiperidine is a shitty stimulant with mainly noradrenergic effects, which doesn't sound promising...
Click to expand...

Based on the OPs description it sounds like the the heterocycle would be azetidine rather than pyrrolidine. It is rather late so I may have misread :S
 
MDMA - Substituting the Oxygen?

Would theoretically substituting the "Dioxolane" portion of MDMA with a nitrogen species "Imidazole" or "Imidazolidine" (the saturated equivalent) make this compound more or less active than the parent compound?

Just curious... with seeing all these MDMA-like RC's on the market today (particularly the "furan" types) this idea has piqued my interest.

Is there a simple reason why this wouldn't be a viable substitute for MDMA?

I don't see any reason why it couldn't be synth'd, but I digress its been a few years since I've dabbled in O chem.

theoretical_derp.png


Pic related, 9000 hours in MSpaint
 
Cone said:
Would theoretically substituting the "Dioxolane" portion of MDMA with a nitrogen species "Imidazole" or "Imidazolidine" (the saturated equivalent) make this compound more or less active than the parent compound?

Just curious... with seeing all these MDMA-like RC's on the market today (particularly the "furan" types) this idea has piqued my interest.

Is there a simple reason why this wouldn't be a viable substitute for MDMA?

I don't see any reason why it couldn't be synth'd, but I digress its been a few years since I've dabbled in O chem.

theoretical_derp.png


Pic related, 9000 hours in MSpaint
Click to expand...

I seem to recall these being horribly neurotoxic. Might have been a Nichols study.
 
Cone said:
Would theoretically substituting the "Dioxolane" portion of MDMA with a nitrogen species "Imidazole" or "Imidazolidine" (the saturated equivalent) make this compound more or less active than the parent compound?

Just curious... with seeing all these MDMA-like RC's on the market today (particularly the "furan" types) this idea has piqued my interest.

Is there a simple reason why this wouldn't be a viable substitute for MDMA?

I don't see any reason why it couldn't be synth'd, but I digress its been a few years since I've dabbled in O chem.

theoretical_derp.png


Pic related, 9000 hours in MSpaint
Click to expand...
is the single nitrogen in 5-IT not enough for your taste? ;)
 
I was just joking about the MSpaint :)

I used BKchem to draw those.

Upon further review, it seems the two lone pairs on oxygen are necessary (at least the oxygen in the 4th position) to H-bond with the receptor.

Nitrogen, with its single lone pair + hydrogen would be vastly inferior in this regard. And probably toxic.

There was a thread on here a while back about using "Benzoxazole" (one O and one N) that proved promising...

I wonder if the resonance within the 5-membered ring helps or hurts its potency...
 
I sure wouldn't take a fluoroamine, but I think that the tendency towards explosive decomposition might not be nearly so pronounced with fluorine, compared to the other halides.

Compare nitrogen trifluoride with the other trihalides. Nitrogen trichloride/tribromide/triiodide will explode at pretty much no provocation whatsoever, but the trifluoride is actually used industrially, supplied in pressurized cylinders.
 
Yes explosive drugs would be interesting, just be very careful when administering per rectum.
 
To be fair, that seems OK for most uses, I could happily use it to do pretty much anything I would want to for a BL post. Still, Symyx has a lot more features, and is just a more polished and professional product, and it's free, so I don't see why you wouldn't download it, but yeah, that applet (is it an applet?) isn't bad at all (better than some I've been forced to used in the past).
 
is marvinsketch available free? I don't find symx wanting for anything really, it's pretty good at churning out IUPAC names for structures (although fails with some, like dxm for example). NMR prediciton would be nice perhaps.
 
Why people doesn't download a cracked chemdraw version on "the pirate bay"?
Ok, it's illegal in most country, but using drugs too...
 
Internet piracy is not something we discuss on BL. Besides, IIRC it's hard to find a valid key.
 
A very good free drawing program is MarvinSketch

Also: Why haven't these been made? Or are they and I am just stupid?

2mgr4ig.png
 
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