I Like to Draw Pictures of Random Molecules

[King Kong]

What makes the amines so important, why don't we get phenethanols or tryptanols(?) ? Somehing to do with it being basic I presume.

Yep! If I remember correctly, the amine have to be protonated to bind to the different serotonin receptors. So it's related to the basicity of the amine...

 

[RtHonLordBob]

 

[endotropic]

Why not give the first one a 5' hydroxy a la serotonin?

 

[babylonboy]

Well, then it would be really unstable and probably too polar too penetrate the BBB well.

 

[SeenSoFar]

I believe the first one was in Ralf Heim's thesis, the same one containing RH-34 and 25I-NBOMe. If memory serves me right it is either untested or an antagonist at 5-HT2a, but I will have to double check to be sure. I am close to 100% positive that he did in fact synthesize it though.

 

[Pression]

GPCR ligand 0.23
Ion channel modulator 0.30
Kinase inhibitor -0.51
Nuclear receptor ligand -0.18
Protease inhibitor -0.20
Enzyme inhibitor 0.22

miLogP -1.703

or

GPCR ligand 0.28
Enzyme inhibitor 0.27

 

[QUARE]

So how do I link a picture to this? I have a brand new phenethylamine.

 

[babylonboy]

Upload the image to a hosting site then use the

 

[Cruel Intentions]

LOL. This thread is fucking hilarious. I love it.

 

[QUARE]

I let you guys find the name for this

 

[Cruel Intentions]

Impossamine. Did you butcher an idea from Buckminster Fuller?

 

[QUARE]

I only tried to put as much methylenedioxy and phenylethylamine as possible in the same molecule lol

 

[QUARE]

How about this one
Carfentanil-APB ???

Would it be opioid, serotoninergic, both or none ?

 

[Cruel Intentions]

None. LOL.

 

[sekio]

what's going on with the Texas peroxy oxygen with a methyne off of it?

if you fix that up chances are it wil follow the fentanyl SAR. the presence or absence of methylenedioxyphenyl grous is by no means a metric for "is this an empathogen or not".

 

[QUARE]

Im just playing lol, I have no idea how this work.

 

[Pomzazed]

{big picture}
I let you guys find the name for this

Nay, the molecule will spontaneously decompose to dodecahydroxydodecadehydrocoronene (the core) and 3,4-(2,2-dihydroxymethylenedioxy)phenethylamine.
The latter might then break down to glyoxal too...

 

[QUARE]

Nay, the molecule will spontaneously decompose to dodecahydroxydodecadehydrocoronene (the core) and 3,4-(2,2-dihydroxymethylenedioxy)phenethylamine.
The latter might then break down to glyoxal too...

Intresting, would 3,4-(2,2-dihydroxymethylenedioxy)phenethylamine be active ?

 

[sekio]

unlikely. the methylenedioxy group doesn't tolerate much bulk, and chemically a geminal dihydroxy compound like that would decompose to water and 2-keto-MDPEA.

 

[Incunabula]

Ketamine without the ketone? I can't find anything about it, any one knows anything? it must have been made.