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  • BDD Moderators: Keif’ Richards

I... I got high.... Why?? How??? And help me replicate this pl0x!

A

alt 14

Bluelighter
Joined
Jul 20, 2008
Messages
585
I am currently on the following: seroquel xr 600mg at night, lamictal 100mg at night, 60mg geodon in the morning, and lastly an additional 60mg of geodon at night. I will eventually come off the seroquel and afaik that's the only other change coming up regarding my meds.

Today I found and insufflated 30mg of d/l amph and ate 10mg ~30 mins later. I got high, and ate a final, additional 10mg about 45m after the last dose. Got a little higher yet. Don't get me wrong, I could handle my shit, and it wasn't quite like I remembered, but somehow, the amps broke through all my anti-psychs. Noticeable euphoria, substantial stimulation, and yes, pupil dilation. I'm still feeling it.. How is this possible when .25g of allegedly good cocaine hardly phased me on the seroquel alone? I know, it was probably destined to end as a foolish and futile attempt to get high since I'm on a transition period with my meds, but taking them home and/or pocketing them was simply not an option. Would've been way too much potential for legal and related repercussions and reprimand, but this isn't important.

Does this have something to do with the pharmacology of coke vs amps with the APs and mood stabilizers, or is it dose related? Or is it dumb luck? Or..? I even entertained the possibility of exaggerated effects stemming from something similar to placebo, but I didn't placebo the pupils, and it's doubtful I made up the heart rate increase.


If no cause is found, that's fine. I have another question for you BL; what's the least amount of time I can skip my geodon for, when I'm stabilized on it alone, and still get increased effects from dopaminergic dugs like amps or ethylphenidaet? I read the half-life is 7 hours, so it would be eliminated in about 3days of non-use according to crazymeds article linked below? Or am I misunderstanding this? Also can I draw the conclusion I may experience stronger effects after 48hours or even 72hours of abstinence from my AP(which I know no one would recommend) because less geodon will be in the brain meaning my D receptors are no longer saturated meaning there's extra holes for the stim to plug up? Or does it simply not work that way?

Thanks, and I'm also up for other advice or factoids regarding AP drugs and getting high with D-related CNS stims. Appresh mucho!

http://www.crazymeds.us/pmwiki/pmwiki.php/Meds/GeodonPharmacokinetics
 
Well I was under the impression geodon and seroquel were both hogging up my dopa receptors, and that's the one associated with euphoria. Weak, you say? Hmmm ok. Geodon too or no?

Also, how long past last dose of geodon is required for the meds to leave the brain? I'm so confused and understand probably 5% of what I'm tying to talk about so laymens would tickle me pink.
 
tweex said:
Seroquel is only a weak dopamine antagonist and does not effect norepinephrine. That is the best explanation I've got.
Click to expand...

quetiapine doesn't affect norepinephrine directly, it is actually a strong NRI in vitro through it's major metabolite norquetiapine...

and taking amphetamine with all those neuroleptics will strongly work against the dopaminergic effects of the amphetamine. perhaps the neuroleptics allow you to enjoy the amphetamine without it becoming too intense, but you probably want to stay away from it if you require those doses of anti-psychotics.
 
With the types and amount of medication the Op is prescribed i think its safe to say there is a diagnosis of bi-polar or psychotic type diagnosis.
With this in mind, i think its not a good idea to skip medication, OP.
These medications work by building stable blood levels and upseting this balance could bring back a resurgence of former symptoms. This would be futher aggravated by taking amphetamines or amp-type drugs, which are well known to cause or worsen psychosis.
Im sorry i havent got a answer to your question OP but i felt a mild warning was appropiate.

seems like jktm just beat me to it anyway.lol

Thanks NT. :-)
 
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Yes I have had psychotic episodes in the past, but I haven't heard voices in probably about 1.5mths which probably doesn't sound like much but it is to me, after hearing them everyday for over a year. Accidentally skipped the seroquel last night but did take the geodon and if I'm being being honest ended up finding another 30mg which made it up the nose after the geodon.. Oops... Well maybe I got lucky but no voices even after being up all night, and the morning dose of geodon really took the edge off and I managed to sleep a solid 4hrs. And I haven't done coke in months and only maybe on 3 or 4 occasions since my diagnosis. For amph, it's been 2-3yrs since I've used.

Back on topic of OP, still looking for an answer of how long would even affect the levels of geodion in the brain regarding it acting as a dopamine antag? If I was going to go against all advice medical and otherwise. If no one knows I may take a 3day hiatus from the geodon once everything is stabilized and do some experimentation with Ethylphenidate. Course I will let BL know how it went so no one else has to.. Thanks for the opinions thus far; I really liked the hypothesis about the anti-psychs allowing the amphetamines to be enjoyable but not over-powering and would like some science to back that up, because that's about what it was like.

Second thought, I will try EPH 24 hrs after the geodon to start out because it seems a bit more rational than jumping off my meds for three days without even knowing it will help. But if no effects are present, like the coke which I now suspect may have been bunk, I will definitely work toward that. This is all at least 3-4 weeks away but I still want to be able to enjoy the occasional drug despite being diagnosed schizophrenic.
 
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From what data i could scrounge up on ziprasidone it seems that its max halflife is 7hrs with little acummulation even when administered by I.M roa for three days.
Basically this means that 24hrs should be enough to clear the drug from your system.
However, apparently a withdrawal syndrome has been observed with symptoms including tachycardia. This wouldnt be a good situation with amphetami.e added on top, think going to the ER with heart attack symptoms etc.
Ziprasidone can also cause heart problems all by itself by increasing the QT interval and causing some rare, possibly fatal heart arrhythmias.
So, again mixing with amphetamines could be a bad idea.
I know that these warnings are likely falling on deaf ears and you will do what you think is right but i hope you will at least be careful as your creating quite a cocktail there.
 
alt 14 said:
Yes I have had psychotic episodes in the past, but I haven't heard voices in probably about 1.5mths which probably doesn't sound like much but it is to me, after hearing them everyday for over a year. Accidentally skipped the seroquel last night but did take the geodon and if I'm being being honest ended up finding another 30mg which made it up the nose after the geodon.. Oops... Well maybe I got lucky but no voices even after being up all night, and the morning dose of geodon really took the edge off and I managed to sleep a solid 4hrs. And I haven't done coke in months and only maybe on 3 or 4 occasions since my diagnosis. For amph, it's been 2-3yrs since I've used.

Back on topic of OP, still looking for an answer of how long would even affect the levels of geodion in the brain regarding it acting as a dopamine antag? If I was going to go against all advice medical and otherwise. If no one knows I may take a 3day hiatus from the geodon once everything is stabilized and do some experimentation with Ethylphenidate. Course I will let BL know how it went so no one else has to.. Thanks for the opinions thus far; I really liked the hypothesis about the anti-psychs allowing the amphetamines to be enjoyable but not over-powering and would like some science to back that up, because that's about what it was like.

Second thought, I will try EPH 24 hrs after the geodon to start out because it seems a bit more rational than jumping off my meds for three days without even knowing it will help. But if no effects are present, like the coke which I now suspect may have been bunk, I will definitely work toward that. This is all at least 3-4 weeks away but I still want to be able to enjoy the occasional drug despite being diagnosed schizophrenic.
Click to expand...

Tbh if you dont want to hear voices, and you want to ditch the seroquel( which i dont if you want but i very strongly recommand it), stop the sero and dont binge on amps. Take your normal dose, and find a strong enough med to kncok u out, ambien if you like it, or another sedative. Benzos would work but you wwould need a reasonable dose and being addicted to benzos is hell. I mean if you dont need it, for anxiety and shit, i think it would be unwise to take them. THe more you stay up on amps (or even whitout them), the more you will experience psychosis if you have a tendency for that. Good luck man
 
Well I've heard about the QT interval bit before... Can't say I understand it, but I've been taking 25/200 ephedrine caffeine 3 times a day for the past 5 days (except a few hours before the amps and not since because I still kind of feel residual effects) and that hasn't killed me yet. Was going to tell my doc I couldn't stay awake without it nor could I focus or give a flying fuck about anything, but he's on vacation for another like 4 or 5 days. Got his voice mail. My lips are sealed with the amps though. I'm guessing if I die from that before he gets back - well I don't know what, but it's more of a need than I just want to take stims because of geodons side effects and my ADD the doctors refuse to address at all since I've been diagnosed schizophrenic as well... I finally care if I live or die since seroquel, which he's now taking me off of.. Faggot. I sleep all day if I don't address the side effects myself, and if it kills me, well fuck, he shouldn't have given me it without telling me about any potential side effects and what to do or not to do about them. Wheres the guidance? I really don't think little insane me should have to look this all up myself and guess when the MD could've given a more direct warning than "and try to stay off the drugs mmkay? Cya in a month"


Idk it's hard to care anymore. Being taken off the only medicine out of 6/7 that's actually worked to rid me of psychotic symptoms a mere month after starting it is discouraging from a patient point of view. Literally ALL of them have caused me severe problems, and most simply just don't work. Gained 75lbs in 1yr, lost tooth enamel from 4 str8 months of DAILY vomiting, and on and on.

</rant>

Continued thanks! Rethinking recreational drugs altogether tbh but I presume this thought will subside.
 
I hope you manage to get your meds balanced out right as i know from personal experience how difficult mental illness is to treat and how the medication side effects are worse then the conditions symptoms.
You really do need to discuss all this with your doctor and dont be fobbed off, you have a right to all the information regarding your treatment and meds.
If the sedation is that big a problem then something like modafinal might be more suitable for you, again you have to discuss this with your doctor.
I think the reason your doctor isnt really addressing your ADHD is because the accepted treatment for it is amphetamines or methylphenidate, both of which are unsuitable for someone with a history of psychosis.
This is the same reason i think you need to be very careful with your use of amps and coke, it could very well all end in tears...or worse.
 
Geodon. Taken from crazymeds, relevant to answering questions of the thread for others when UTFSE may arise.

"... and these three things seem to have different effective half-lifes:

1) 5HT2A-blockade: almost 20 hours;
2) D2-blockade: probably between 12 and 20 hours (see mentioned studies);
3) SNRI: probably less, namely closer to the actual half-life of the drug = about 7 hours!"

So 24 hours after last dose of geodon there will be significant dopamine antagonism, and at 48 hours post-dose, substantially less. Will experiment at 24hours, 48hours, and if required, 72hours with recreational drugs and report with anecdotes regarding effects. Thanks again to everyone in the thread and I hope people searching things like anti-psychotic antipsychotic drugs and coke amphetamines opiates recreational drugs will find this useful tid-bit about Geodon and seroquel. Of course, I suggest no one skip their medicines and those with drug problems and mental illness to be cautious with drugs.

http://www.crazymeds.us/CrazyTalk/index.php?/topic/8055-side-effects-8-hours-after-dose/
http://clinicaltrials.gov/ct2/show/NCT00818298
 
Well i suppose that since your not to be dissuaded from your experiments, that i gotta wish you good luck!
Its great that you have went to the trouble of researching your meds and understanding their MOA, i hope you can carry that thoughtfulness through into your actual drug use because ive seen the best intentions go badly wrong in this situation a number of times.
Anyway, no more warnings from me (honest.lol), just let us know how you get on and again, good luck.
 
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