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I hypothise that verapamil is the solution for MDPV induced pro psychotic effects.

MeDieViL

MeDieViL

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The evidence behind my hypothesis is low and based on a rodent study with amphetamine, however as im a very optimistic person i beleive it may work, only anecdotes can provide some insights, hey i was right about memantine for tolerance.

Behavioural and anti-psychotic effects of Ca2+ channel blockers in rhesus monkey.
Palit G1, Kalsotra A, Kumar R, Nath C, Dubey MP.
Author information 1Primate Behaviour Laboratory, Division of Pharmacology, Central Drug Research Institute, Post Box 173, 226001, Lucknow, India. [email protected]
Abstract
The potential utility of Ca2+ channel blockers in the treatment of various psychiatric disorders has been recently suggested. In the present study, the behavioural and anti-psychotic effects of Ca2+ channel blockers were investigated in unrestrained rhesus monkeys (Macaca mulatta) living together in a colony. The different behaviours categorised as social, solitary and abnormal were video recorded and analysed. Graded doses of verapamil (5-20 mg/kg, i.m.) and nimodipine (7.5-30 mg/kg, p.o.) produced a mild decrease in social and solitary behaviour without producing any cataleptic posture in the tested monkeys. In order to determine potential antipsychotic effects, Ca2+ channel blockers were studied in the model of amphetamine-induced psychosis. Amphetamine, at the dose of 2 mg/kg, i.m., induced suppression of approach, contact, grooming, and feeding, whilst vigilance (checking), stereotyped behaviour and oral hyperkinesia were increased in the monkeys. Pre-treatment with verapamil (10 and 20 mg/kg, i.m.) significantly suppressed amphetamine-induced hypervigilance, stereotypy, oral hyperkinesia and tachypnoea but was unable to reverse other amphetamine-induced behavioural effects. Nimodipine showed insignificant anti-psychotic effects at both 15 and 30 mg/kg doses. These results suggest that verapamil has a definite antipsychotic effect without any extrapyramidal side effects and thus may be of clinical significance in the treatment of psychosis.
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What happens when you just use a typical antidopaminergic (or multiple antagonist) antipsychotic in someone who is freaking out on peevee?
 
Never worked for me, even risperdal didnt counter the psychotic effects of amp in my case.
 
God I'll never touch mdpv again. It was such a lovely stimulant, but it slowly drove me into full-blown mania which turned my life into a total trainwreck. Still dealing with the aftermath.

So have you tried this yourself yet? There's a pretty easy way of finding out. :D Btw olanzapine was a godsend against mdpv psychosis.
 
Not yet, i will be obtaining both very soon, ive also been thinking about giving olanzapine a try, how does it alter the effects of MDPV for you?
 
MeDieViL said:
Not yet, i will be obtaining both very soon, ive also been thinking about giving olanzapine a try, how does it alter the effects of MDPV for you?
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Do all stimulants give you these kinds of psychotic reactions? This seems like kind of a risky experiment considering you already know how you react to the PV. Why not just take something that doesn't make you so psychotic?
 
All stimulants used to cause some psychotic effects for me as i was predromal shizophrenia, however benzos prevented that and now i dont have this anymore as i pretty much reversed most of my progression to shizophrenia after alot of experimentation.

Stimulants are the only thing working for my anhedonia so i need them therapeutically, i used to combine desoxy and MDPV wich worked great with clonazepam.
 
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