Naturally. I'd say that that's one of the main reasons I take psychedelics actually, and it's why I'm also a fan of dissociatives as well. Leaving the self behind (if only temporarily), was responsible for one of the most positive changes in my life. Up until I was 18 or so, I was an extremely anxious person and always worried about zits and sweating too much. I'd never had a girlfriend, and had trouble meeting new people because I always felt inferior.
I was aware that others were human in the "duh, that's obvious" sense, but I hadn't really integrated it and it's implications into my life. I don't know why, but I hadn't realized that every other person on this planet shits, farts, pisses, sweats, feels like they need to brush their teeth (in first world cultures), vomits, and has had experiences of social rejection and discomfort similar to mine. As soon as I truly became
aware of this (shrooms are to thank), things became a lot easier. I have more than decent hygiene, and if someone has a problem with it, fuck them. They're the ones in denial about their own messy monkey nature. :D
That wasn't the only realization. Honestly, it felt like snapping out of a dream---awakening for the first time. That period was one of the most psychologically stormy of my life, brought on doing too many reality bending drugs, having an odd living situation, and doing a lot of philosophy and computer science work. My reality was crumbling around me, and for several months I wondered if I had gone insane, and just was pretending not to be.
These days, I'm still ridiculously picky about women, and I still have trouble meeting new people. I consider myself to be totally insane, and I'm comfortable with it.

It's mostly because I reject consensus reality, and find most people to be shallow and vapid, though. More power to them if they find that it works, but it doesn't stimulate me.
I can enjoy the quotidian but I like knowing that there's some depth behind it.
From my reading, redgreenvines' comments have a lot in common with the views of transpersonal psychology. I've been trying to do some reading from the field. I picked up some of Grof's books, and I enjoyed reading a number of Charles Tart's papers I've found online. The nature of ego is particularly important in my mind, and to what degree should an "enlightened" person try to rid themselves of it? Is it healthy to have in some degree in a world where you'll interact with others that are very ego-centric? I stuck a bunch of links at the bottom that are kind of related; all have been really good thinking material.
My thoughts on the nature of reality and personal interaction are still very tangled, and it hasn't sunk in quite yet how far I am from the norm in terms of beliefs about the world. This was illustrated yet again a day or two ago while watching the Democratic debates with a friend's housemates (smart, college educated folks). The women were talking about hair and men, and the men were talking about the candidates responses. It was all very archetypal. My friend and I were the only ones objecting to the lack of concrete policy debate at all on substantive matters. Beyond that, nobody seemed to realize that politics as presented on TV is a giant charade, meaningless on an individual level. All this YouTube "internet democracy" stuff is mental masturbation.
Seeking the Stone - A presentation by McKenna, where he explains his views on human evolution, mushrooms, Eden, and such. Make sure to watch both halves of it, the link to the second part is on the side.
The Nature of Consiousness - A transcribed presentation of Alan Watts' that I think makes a convincing case for adopting the "it's a giant joke" view of the world (very much paraphrasing there).
Slavoj Zizek on "unknown knowns" - I love Zizek, and although he can be a little hard to understand, his speeches are funny and much less dense than his books. This is an incredibly wide ranging talk as well, and has so many worthwhile insights, even in the Q & A part.
Yes, We Are Zombies, But We Can Become Conscious! - Charles Tart - This is a deeply interesting paper, and explores the question of whether our behavior comes from true "consciousness".
P.S. The "transactional memory" thing is a really obscure bit of computer science. It's a method of getting rid of the locked critical sections that RGV mentions. I wasn't being flippant, I promise.
