☠ WARNING ☠ I don't care what anyone says, 700 mg of cbd is hallucinogenic.

[donotdothis]

If you haven't had it, don't post about it.

 

[Kaleida]

Phytocannabinoids are definitely hallucinogenic for me. THC, CBN, and CBG all give me a good quasi-psychedelic trip at around 40 mg taken orally. Oral CBN (without any THC or CBD added in, just CBN alone) is actually one of my favorite drugs of all time and I highly recommend that every single person reading this try taking it since it’s so easy to obtain these days.

 

[red22]

Nah, it's just THC contamination.

Also, some CBD oil is actually extract of high CBD cannabis, which contains plenty of THC in large amounts.

 

[donotdothis]

"It was just like looking at the mirror on LSD, but I was looking at the cat on cbd."

 

[Didgital]

Uhhh. I wouldn't even really call it psychoactive.
I've taken grams orally and dabbed 100mg crystals (tastes like cherries if you haven't)

 

[xdrc]

I think some of the early high purity CBD entrepreneurs have taken it in high doses without psychoactive effects. Not discounting your experience, but can you disclose with which kind of material you had it? I'd be curious to which extent aforementioned contamination with THC can be ruled out.

THC easily induces OEVs and CEVs for me, especially when taken in high doses orally, even though I'm usually more resilient against getting visuals from psychedelics (not that they aren't visual, but from what I can gather not nearly as much as they are for other people).

 

[Innerpeace]

I've had good amounts of decarbed CBD, I don't know how to measure the mgs though.
Do you mean seven hundred mgs of decarbed CBD?

Decarbed thc might. It makes me really dizzy , unmotivated, where I just want to lay in a recliner.

I may have easily taken seven hundred mgs of both.

 

[Allylbenzene]

Phytocannabinoids are definitely hallucinogenic for me. THC, CBN, and CBG all give me a good quasi-psychedelic trip at around 40 mg taken orally.

I don't know what dose but CBG isolate smoked & ingested is interesting. The adrenergic effects are worthwhile.

Uhhh. I wouldn't even really call it psychoactive.

That explains a lot tbh. Also CBD is known to have antipsychotic qualities so perhaps this is relevant?

Cannabidiol...has emerged as a potential novel class of antipsychotic with a unique mechanism of action.
10.1177/2045125319881916

Based on these findings, we propose that CBD acts as a negative allosteric modulator of 5-HT2A.
10.1016/j.cellsig.2025.111588

I'd be curious to which extent aforementioned contamination with THC can be ruled out.

The presence of THC would inevitably be the #1 rationalisation for why CBD produces hallucinogenic effects; and if that doesnt stick then I bet the concept of gastic acid-induced CBD isomerisation would be used... anything that provides a rational explanation which supports the underlying presupposition (that CBD is non-hallucinogenic). Or in the case of Didgital, that CBD is non-psychoactive. Mind you he also believes terpenoids are inactive so... (based on his posts I'm not too surprised that he finds many things non-psychoactive). The issue is that he assumes items are universally non-psychoactive, when it's just him.

 

[ChemicallyEnhanced]

If you haven't had it, don't post about it.

Not IME (I've taken up to 1000mg in a single dose). I definitely felt some high, though. But everybody is different.

 

[Didgital]

@Allylbenzene Really interesting that you feel the need to comment on all my posts since the bullshit LSI thread was locked.

Yeah i wouldnt know anything about cannabinoids or CBD. Ive only isolated about 30,000kg at this point. I used to dab 100mg at a time. Mildly psychoactive at best. Again i said id be happy to send you some isoborneol for free if you wanted to dab pure terpene.

 

[Allylbenzene]

Really interesting that you feel the need to comment on all my posts since the bullshit LSI thread was locked.

Actually —putting aside your pseudo-schizophrenic perceptual tendencies— I was primarily looking at xdrc's posts in various threads. My subsequent responses correlate accordingly, whether to xdrc or others. You happen to be involved.

Yeah i wouldnt know anything about cannabinoids or CBD. Ive only isolated about 30,000kg at this point. I used to dab 100mg at a time. Mildly psychoactive at best.

I'm curious if you've a history of SSRI medications or other S×RI perhaps? As CBD is a documented antipsychotic then perhaps this explains your reaction?

Again i said id be happy to send you some isoborneol for free if you wanted to dab pure terpene.

As I told you the first time when you offered some isoborneol – I've already got a broad assortment of terpenoid isolates and near pure isolates. The multinational agreed to sell me below their MOQ of valencene which was great.

 

[xdrc]

The presence of THC would inevitably be the #1 rationalisation for why CBD produces hallucinogenic effects; and if that doesnt stick then I bet the concept of gastic acid-induced CBD isomerisation would be used... anything that provides a rational explanation which supports the underlying presupposition (that CBD is non-hallucinogenic

If we're talking about ingesting gram-quantities of CBD to reach effects, yes, THC contamination and even cyclisation must be eliminated as a possibility. We have credible reports of people saying it is not active and reports of people saying it is active. The sane thing to do is taking control of the parameters which may differentiate the two outcomes, if it is contamination, trace metabolites, different metabolic pathways, synergies, etc. I don't know what your issue is with that.

 

[Esperighanto]

I've taken grams orally and dabbed 100mg crystals (tastes like cherries if you haven't)

I've also taken grams orally, and I've also dabbed grams of it before. These samples all had CoAs from state approved and licensed laboratories/dispensaries back in Maine, and the experience of crossing maybe 1.5-2g dabbed and 2.5-3g orally felt blatantly empathogenic. Taking my shirt off to slink across the shag carpet type empathogenic. Maybe there was contamination that wasn't noticed in the lab, but I'd be surprised. Maybe some people just respond to it in different ways? I'm not sure but I have often wondered about why this variation seems to occur, we got the effect reproducible in others and noted BP/heart rate changes too, and a mild fever iirc? I need to find that old notebook with the measurements in it from ~5 years ago to actually pull data on it.

As I told you the first time when you offered some isoborneol – I've already got a broad assortment of terpenoid isolates and near pure isolates. The multinational agreed to sell me below their MOQ of valencene which was great.

Genuine question for you as well as Didgital (not trying to stoke any further conflict or whatever) but I recall that dihydroxybenzonorbornane was what Shulgin used for 2C-G-5, if I'm remembering correctly. He also mentioned that a similar compound could've been used for a hypothetical psychedelic he referred to as 2C-G-6 in the extensions and commentary section of the 2C-G-5 article. He specified that he believed the dihydroxybenzonorbornane to have been an adduct of a couple things. Without going much further into chemistry talk here, I want to broadly ask the question: Do you guys suspect that in a similar way to how there is a virtually infinite array of possible 2C-T-X compounds, do you also suspect that there is perhaps a plethora of 2C-G-X compounds that may some day be explored?

If we're talking about ingesting gram-quantities of CBD to reach effects, yes, THC contamination and even cyclisation must be eliminated as a possibility. We have credible reports of people saying it is not active and reports of people saying it is active. The sane thing to do is taking control of the parameters which may differentiate the two outcomes, if it is contamination, trace metabolites, different metabolic pathways, synergies, etc. I don't know what your issue is with that.

Cyclization? Is the idea that CBD may cyclize either while in storage or metabolically perhaps? I'd love to learn more about this, especially if we could get Abn-CBD to cyclize and maybe hit the "CB3/CB4/CB5" receptors (formerly I referred to them as GPR55, GPR119 and GPR18 but they truly do appear to be just cannabinoid receptors, as far as I can tell so far).

Edit: @xdrc I'm also curious if the cyclization idea could extend to being able to make prodrugs that perform annulation in some way, as opposed to cyclization? I'm sure all of this is greatly underexplored territory, but if you have any literature or references on it I'd be more than happy to hear about them! Very neat stuff here.

 

[Allylbenzene]

Is the idea that CBD may cyclize either while in storage or metabolically perhaps?

Not in storage afaik, but people tend to use anything from acetic & citric to phosphoric, S & H. In the in-vivo context, possibly by combining cbd isolate with betaine hcl?

Betaine HCl is the hydrochloride salt of betaine...
...betaine HCl readily releases H+ in an aqueous environment (approximately 0.65 mmol/100 mg).
...
Betaine hydrochloride is a natural substance typically used as a dietary supplement to enhance stomach acid levels (source)

Technically all the CBD beverages are producing THC....

Nevertheless, it is certain that CBD degrades to psychotropic products in acidic environments. Hence, the storage stability of commercial formulations requires more attention in the future.

https://doi.org/10.3390/toxics8020041

Do you guys suspect that in a similar way to how there is a virtually infinite array of possible 2C-T-X compounds, do you also suspect that there is perhaps a plethora of 2C-G-X compounds that may some day be explored?

Most likely.
I've been exploring the 2C SAR recently but reading your post I apparently overlooked the 2C-G-× style(!)

 

[Esperighanto]

I've been exploring the 2C SAR recently but reading your post I apparently overlooked the 2C-G-× style(!)

I know that translating it from German to English can be a hassle, but also things like Trachsel's 2C's (2C-V, 2C-YN, etc.) and their 4C/DO/N-benzylated derivatives are quite exciting to read about! I hope at some point they become more accessible, thankfully their synthetic routes aren't that bad. Also a little bit of a tangent but TGF-8027 ( https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c01855 ) is quite interesting and shows a useful substitution site on N-benzylated phenethylamines that I was completely unaware of. I'm not sure what the position would be called (alpha-prime? The one to the right of the nitrogen where TGF-8027 added the extra methyl to 25CN-NBOH) but I wonder what other substitutions could be useful there.

 

[Allylbenzene]

I know that translating it from German to English can be a hassle, but also things like Trachsel's 2C's (2C-V, 2C-YN, etc.) and their 4C/DO/N-benzylated derivatives are quite exciting to read about!

I'll look at Trachsel's stuff thanks for the pointer. I've been exploring the more (so-called) basic SAR involving eg aminotetralins amongst other things. All the papers are from the 80s and 90s...

...N-benzylated phenethylamines...but I wonder what other substitutions could be useful there.

That reminds me of this LSD analog #11 with the same or greater potency as LSD.

https://doi.org/10.1021/acsmedchemlett.4c00593

 

[donotdothis]

person B doesn't use shampoo

 

[Esperighanto]

I'll look at Trachsel's stuff thanks for the pointer. I've been exploring the more (so-called) basic SAR involving eg aminotetralins amongst other things. All the papers are from the 80s and 90s...


That reminds me of this LSD analog #11 with the same or greater potency as LSD.

https://doi.org/10.1021/acsmedchemlett.4c00593

Fascinating paper once more! We should get together some time and just exchange .zip archives of the papers we've been accumulating. I'm sure there's bound to be quite a bit of overlap, but nothing a little command I could whip up in bash couldn't solve to eliminate redundant files. DM me if you're interested in doing this!