Aetherius Rimor
Bluelighter
- Joined
- Jan 16, 2012
- Messages
- 404
Until the past month, I've been hypersensitive to cannbinoids all my life. One hit of high grade would make me miserable with eye pressure, head buzzing, anxiety, and inability to move or speak. If I did anymore I would start getting extremely dizzy and start throwing up from what felt like "motion sickness".
I've had weight problems since I was a teenager and put on bi-polar medication (Zoloft, Depakote, and Risperdal). Over eating and being constantly hungry no matter what. I did not try cannabis or any other recreational drugs until I had been off that regimen for years and was in my 20's; and though I'd lost 100 lbs after quitting my bi-polar medication I still was overweight.
I've finally developed a tolerance to THC to the point I can smoke it regularly without being miserable, and actually enjoy it; but I've noticed that my appetite and hunger are reduced compared to before. This lead me to the following ideas and wanted to get some opinions from others who could confirm or point out flaws:
1. I suspect my bi-polar medication might have increased appetite/hunger by somehow increasing the amount of cannbinoid receptors leading to hypersensitivity. This is just something I consider a possible cause to hypersensitivity, but not crucial to the hypothesis. If true, it would explain part of the weight gain side effects of bi-polar medication in addition to general lethargy and reduced metabolism.
2. Having now gained a tolerance, my appetite/hunger has been reduced (when not smoking) due to down regulation of receptors and endogenous cannbinoids not triggering as strong of a response for hunger.
3. Through this mechanism of action, Cannabis can act as a long term appetite suppressant through regular usage causing down regulation; and allow times of hunger to be more controllable.
Anyone with more expertise able to further speculate on this?
I've had weight problems since I was a teenager and put on bi-polar medication (Zoloft, Depakote, and Risperdal). Over eating and being constantly hungry no matter what. I did not try cannabis or any other recreational drugs until I had been off that regimen for years and was in my 20's; and though I'd lost 100 lbs after quitting my bi-polar medication I still was overweight.
I've finally developed a tolerance to THC to the point I can smoke it regularly without being miserable, and actually enjoy it; but I've noticed that my appetite and hunger are reduced compared to before. This lead me to the following ideas and wanted to get some opinions from others who could confirm or point out flaws:
1. I suspect my bi-polar medication might have increased appetite/hunger by somehow increasing the amount of cannbinoid receptors leading to hypersensitivity. This is just something I consider a possible cause to hypersensitivity, but not crucial to the hypothesis. If true, it would explain part of the weight gain side effects of bi-polar medication in addition to general lethargy and reduced metabolism.
2. Having now gained a tolerance, my appetite/hunger has been reduced (when not smoking) due to down regulation of receptors and endogenous cannbinoids not triggering as strong of a response for hunger.
3. Through this mechanism of action, Cannabis can act as a long term appetite suppressant through regular usage causing down regulation; and allow times of hunger to be more controllable.
Anyone with more expertise able to further speculate on this?
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