• N&PD Moderators: Skorpio

Hypnotic effects of acetophenone

No, I'm not suggesting it would have any recreational value as such. It's just that I seem to remember the compound being mentioned somewhere (can't remember where that would be though)
 
heh I'm just busting your chops.

google says no though. It's cheap as hell, though.
 
without even knowing what receptors it effects - I'd bet GABA-A receptors, given that many simple ketones do, but I dunnoooo for sure. Not likely to be researched unless someone wants to pay for an assay, which isn't all that expensive, but I'm not interested in it enough.
 
There should be data since it was used as medicine before in the old days. Anyone found something informative?
 
Acetophenone is used as a mammal repellent where I work. Jesus does that stuff smell. I couldn't imagine someone just slurping it back out of a bottle like cough syrup... it turns my stomach thinking of it. I see why they reccomend to use capsules/pearls.

If it does work I would expect it to be a messy drug like chloral or ether. Messy, crude, and stinky. I have a feeling this is one of those drugs which are useful only as a scientific curio and not actually meant for regular usage.
 
"With ip injection of 0.4-0.5 g/kg to rats, staggering occurred after 5 min, paraparesis in 13 and quadriplegia in about 20 min. ... Expt on guinea pigs, profound torpor, with gradual loss of reflexes, rapid, somewhat irregular resp, weak cardiac action, lowering of temp and some convulsive movements. In dog, with iv injection, deep sleep was followed rapidly by analgesia and anesthesia, dilatation of pupils with diminished light reflex, resp and cardiac modification, with lowering of blood pressure, feeble pulse and resp arrhythmia."

http://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+969
([Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 453])
 
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