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Hypnotic effects of acetophenone

wungchow

wungchow

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According to wiki and several other sources, Acetophenone used to be sold as a sleep aid under the brand name "Hypnone" back in the early 20th century.

acetophenone.GIF


I know acetone purportedly has sedative effects as well. Is it a nonspecific interaction with GABA receptors, like ethanol?
 
For some reason I thought that acetone interacted with calcium channels. Could be totally wrong though.

acetophenone scares me for some reason, though I see it's not mutagenic and is present in a lot of products.

Keeps these up though! Always interested in new sedatives and hypnotics (those involving GABA anyway!).
 
i cannot imagine someone wanting to ingest the stuff.

much better to use in a Mannich followed by a Grignard
 
You guys have no clue about chemistry. Stop uttering nonsense.
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I don't see anything wrong with what Smyth says. That it would produce an amide, otoh, is nonsense.
 
Ah yeah, anticholinergic was my guess, too. Trihexyphenidyl is indeed a possible derivative of the suggested route.
 
Smyth said:
some sort of anticholinergic if i recall correctly.

E.g. trihexyphenidyl
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Yeah, Smyth is right, I retract my criticism. But: who would bother making Trihexyphenidyl? It's cheaply available as an API, and who (except some freaks) would want to use it recreationally anyhow? Also, the proposed synthesis requires piperidine, which is a tightly controlled presursor due to its use in the synthesis of PCP.
 
I dunno, it's a commonly abused drug, especially in france and some eastern european nations
 
I also remember acetophenone is used to make Prozac and atomoxetine, and nisoxetine.
 
seems that the method you use to get Artane could also get you an opioid, no? Not all that different from methadone sorts.
 
No, that cannot happen here. With propoxyphene it is possible.

The steric crowding around the alcohol with 2 phenyl groups:

Ph2C(OH)CH2CH2NR2

you cannot esterify that position easily and it is very unstable.
 
http://en.wikipedia.org/wiki/Acetophenone says that Acetophenone was used in doses up to 0.3 ml. Other sites claim that it was extremly toxic and causes severe intoxications even if it was inhaled in concentrations about a few ppm.


Seems like nobody in here has tried this substance before... I did not expect that.

Anyway:

My primary question is how toxic/dangerous is it really?

If it's not too toxic, how long could it be taken without developing dependency?
 
The stuff smells weird. It's like a cross between benzaldehyde and some really weird synthetic plastic.

I also want to mention that the material of my last post is pharmacologically active in its own right and does not need further reaction.
 
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c0rt3x said:
Seems like nobody in here has tried this substance before... I did not expect that.
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Yeah, strange! People ingest other solvents and synthesis reagents all the time, why not this one?! ... :\ This can't be true...
 
As I recall, people ingest this stuff all the time. I'm pretty sure it's in some food products. Or maybe only gum? I don't recall right now.
 
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