Hydroxyzine and Tryptamines

[Professer]

So hey there. I use it, hydroxyzine, to get to bed sometimes. It shows to have been shown to act as a 5-HT2A (Ki = ~50 nM), D2 (Ki = 378 nM), and α1-adrenergic (Ki = ~300 nM) receptor antagonist. Half like is ~20 hours.

Say I want to trip the next day. Should I be concerned? Wait longer and not take it? Will it dampen the effects? From what I understand that's not much antagonism, ~50 Ki?


*sigh*

Any help loved and appreciated.

 

[Professer]

No one? Ive searched and not found much... gonna experiment later today with 5-meo-mipt and rue. Got a natural 5-htp suppliment, G. Simplicifolia, that feels to be 'opening up' the receptors so far. Trip around noon.

 

[Ineffable14]

I've used hydroxyzine to sort of abort a trip before. So it def has the potential to kill or dull a experience.
Check out the half life. I'd give it a few days for your body to return to homeostasis.

 

[Professer]

I have supplies if it goes bunk to research more

2g rue + 20mg moxy is taking me where i expected, nearing +++

 

[Solipsis]

IIRC 5-MeO-DMT + MAOIs can be quite dangerous so I would be very careful with the analogous moxy. Read up on that and draw your own conclusions.