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Opioids Hydrocodone: Does DXM cause cross tolerance?

Lord 187

Greenlighter
Joined
May 20, 2013
Messages
4
So SWIM got his hands on about 45 5/325 hydrocodone apap pills. He is trying to use them recreationally. At first he tried 15mg, and after about an hour felt nothing. He then tried another 5mg, and another 5mg an hour later. All he felt was somewhat talkative, and tired a few hours after. His pupils were constricted, showing that his body had metabolized the drug. The next day, he did a CWE with 35mg. He drank the liquid and essentially felt tired and angry that the drugs had no euphoric effects that many people describe at the lower doses. However, SWIM has done DXM about 7 or 8 times, never exceeding 400mg of DXM. SWIM is wondering if DXM causes cross tolerance with hydrocodone, and SWIM is wondering how much hydrocodone he should take to feel euphoric effects.

tl;dr: If DXM causes tolerance to hydrocodone, how many mg of hydrocodone would be suitable for SWIM to feel the euphoric effects?
 
i doubt it; i don't think it even hits the mu receptor where you get the good effects from; if it does, it doesn't do it enough to cause cross tolerance.

40mg should do it, are you opiate naive or have u taken other opiates before? the effects are something you learn to love, you probably won't like it the first few times.

also no swimming here.
 
Yes, I am opiate naive. Is 40mg the sweet spot for hydrocodone? Since I've tried it twice before at 25mg and 35mg, will the extra 5mg make that much of a difference?
 
if you don't feel anything worthwhile from ~35mg of hydro, you probably won't get anything super euphoric out of it if you further increase your dose. you could try going all the way up to 50mg, but that is likely to cause trouble with nausea.
different drugs effect different people differently. opioids especially can be rather hit-or-miss, some people are more predisposed to just getting sleepy and possibly dizzy/nauseous, rather than euphoric.

if you are looking for euphoria, go relax and listen to music, smoke a joint and get a massage or something. don't expect to be outright euphoric like mdma or something, esp. off of hydrocodone.

dxm and opioids are not cross tolerant significantly.
 
i took 45mg of hydro as my first opaite experience and i was intensely euphoric. Some people respond differently to different opioids though. stim euphoria > opie euphoria IMO but the warm fuzzies make it close.

there's a reason people IV opiates, and it's not just because they like needles, the euphoria is profound. Not that i recommend that. if you must play with opiates, try 10-20mg of oxycodone, maybe you have a high natural tolerance.
 
I used to take 30mg to get high when I was opioid naive, and it was a good dose for me and worked at that dose for a while. Using it consecutive days will rapidly increase your tolerance though, so you should take a few days off before experimenting with it again, and continue to use it sparingly if you are going to keep using it.

Also, if you don't find it euphoric then there is no need to push the envelope with it. That's like trying to get addicted to the drug. I know that's not really the case, but for the many of us that have become addicted to opioids by starting off on hydrocodone it's hard to watch someone start off on a path that may lead to serious addiction.
 
No need to worry about me getting addicted. I'm firm in this being the only time I'll experiment with hydrocodone. Anyways, I guess I'll do a CWE and try doing 50mg in about a week or so. after that I'll have about 100mg of the stuff left and I'll see where I go from there. If I don't feel anything after the 50mg, then I guess I'll just give up on trying hydrocodone
 
the best case scenario is that you get nothing from hydrocodone and stay away from opiates for good. Although i enjoy them greatly, opiate use and addiction/dependence come at a huge cost, best not to even get an inkling of that opiate goodness, it's hard to forget.
 
Well if you put it that way, I guess I won't even bother with the hydrocodone. I'll just stick to what I'm comfortable with.
 
Idk what's wrong with ya'll, I get a buzz off 7mg (though it's really just enough of a buzz to tease me).

I did DXM heavy and I didn't get any tolerance to hydros, DXM is derived from opiates but it doesn't have the same effect at all. Its molecular structure is closest to PCP than anything. Actually your problem may be that you're expecting a different high. If you think you're going to feel the same way off opiates that you feel off DXM you're dead wrong. Opiates just make you feel good, like a more mellow version of cocaine. They're not disassociatives like DXM and PCP and won't make you trip.

I say don't mess with opiates at all. I say that about every feel-good drug like opiates or cocaine because you will never forget how good it feels. I've been doing hydros for like 3 years now and although I haven't had a noticeable addiction or tolerance I still crave hydros sometimes, not because I'm addicted but because they feel good. Ever crave a food so bad you felt like you were going crazy because you couldn't have it? Imagine that, except knowing that food is going to take your problems away and give you a few hours of pure euphoria.
 
if you don't feel anything worthwhile from ~35mg of hydro, you probably won't get anything super euphoric out of it if you further increase your dose. you could try going all the way up to 50mg, but that is likely to cause trouble with nausea.
different drugs effect different people differently. opioids especially can be rather hit-or-miss, some people are more predisposed to just getting sleepy and possibly dizzy/nauseous, rather than euphoric.

if you are looking for euphoria, go relax and listen to music, smoke a joint and get a massage or something. don't expect to be outright euphoric like mdma or something, esp. off of hydrocodone.

dxm and opioids are not cross tolerant significantly.

I don't really agree, though you're entitled to your opinion. IME though, after being clean for nearly a year (from Heroin and Methadone-which were the first two opiates/opioids I ever tried :/)15mg of hydrocodone had me blasted. I honestly think that if you have a low enough tolerance, Hydrocodone is a pretty damn euphoric opiate, and though most will disagree with me here, and possibly try to crucify me, I would even say that I find its effects more pleasant than Oxycodone. I've always favored good heroin over pharmaceutical opiates, but Hydrocodone is one of the few that has very similar effects to insufflated dope-it's just much weaker. (And I'd say a starting dose would be somewhere between 15 and 35/40mg.)

However I do agree that the opiate 'buzz' is a bit subtler than the euphoria caused by MDMA or Methamphetamine, so for some it may feel underwhelming. I also agree with Sekio that taking more likely won't get you 'higher', but will instead just make you feel sick/nauseous. As for DXM having a cross tolerance..I doubt it, but even if it did, using DXM eight times in your life wouldn't be enough to cause a tolerance to any drug it was cross tolerant with-unless you just started using DXM about a week ago. If anything, DXM should help to potentiate the Opiate and to slow down the rate you grow a tolerance to it.
 
i'd take hydrocodone in equipotent doses over oxycodone any day, though i do like oxy, i prefer a more chill opiate high.

the problem in the US at least is that to get to a nice dose of hydrocodone you have to do a CWE, whereas with oxy it is more potent and isn't necessarily stuck with acetaminophen.

15mg would never have gotten me blasted, i guess i have a high natural opiate tolerance, which is probably why i always end up taking monstrous doses and still don't nod out. Despite that with a low tolerance and 40-50mg of hydrocodone, i really like the high. It's not often anymore i get the chance though as i'm pretty sure here it's only found in syrup form without shitty acetaminophen but rarely prescribed these days. That syrup was my first introduction to opiates.
 
To the above two posts, I found hydrocodone to be one of my favorite opioids, and I prefer it over oxycodone in equivalent doses as well. It's just that once you have a tolerance to oxycodone, it becomes extremely difficult to get high off of hydrocodone.

About 2 years ago I was given 14 of the 5mg hydrocodone pills after having taken a 4 month break, and before that had taken another 4 month break with only a few highs between the two breaks. Anyway the 70mg of hydrocodone had me nodding as one would expect after consuming that large of a dose after taking such a break, but after that one high my tolerance to hydrocodone raised significantly unfortunately.

I had always wondered if I thought that hydrocodone was so euphoric since it was the first opioid that I had abused, taking my opioid virginity, but my preference for it was confirmed after using it after that break and finding it to be just as euphoric as insufflated heroin.
 
Znegative, RobotRipping & TommyBoy; you guys are my new best friends! i prefer hydrocodone to oxycodone 100% & honestly to most other opioids too (although i've never tried heroin, so there's that)...

i've never messed with DXM recreationally (only when i have an actual cough, because it makes me feel sick to my stomach) so i can't speak to that affecting hydrocodone tolerance though.
 
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If anything DXM should reduce tolerance to hydrocodone through NMDA antagonism.
 
it won't reduce tolerance, but help to keep it from building rapidly. Otherwise i'm sure people would be doing shit loads of ketamine to get their opiate tolerance down.

@anythingbutsober: tho i do like hydrocodone, i'll definitely take hydromorphone or morphine over it lol. Then again, it is nice to take your opies orally but i like the morphine high the best.
 
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