a little over 2 g's of apap isn't likely to do any damage. When babies have bad fevers they are given 1 g, at only like 20-30 lbs, so a full grown adult isn't going to have much issue with 2.25 g. The risks typically only begin at >3 g. If you do a CWE just make sure you have a good method that is efficient. That is my issue with a CWE for a one time use with a relatively benign amount of the medication. With a CWE you don't know for sure what you are losing in the process, if you just torpedo them then at least you know you got all of it.
Let me retract that statement, I believe its more for pediatrics in the 60-80 lb range that would take ~1000 mg. IDK, recommendations for home use wouldn't want you to administer that much but in a hospital setting they might have different guidelines for care when dealing with febrile seizures and dangerously high temps. I am just going off an RN 2 a children's hospital asking me how much APAP a child of about 3 yrs old was given at a clinic before being sent to the ER. I didn't know exactly so she just assumed 1 G, I thought that sounded like a lot but with fevers in the 104s the rewards might outweigh the risks. Still you are not risking too much in taking 2250 mg. I am just saying what I would do, and I wouldn't CWE because I don't want to waste any of that 35 mg of hydro. Maybe you should split the difference and wat 4 and CWE the other 3. Then you are cutting the APAP down to a reasonable number and if anything appreciable is lost in the CWE then you are limiting the loses.