How toxic is Mephedrone?

[Vader]

I saw mephedrone pills for sale online, by the hundred and available in a range of popular presses (rolex, doves etc).

 

[evilsnook]

OMG! Soooooo, like, tOXIC!

Sooooooooooooooo, like , toxic, like, if I were, like, you, I'd like, totally stay away from it. Like.... just like....being nice.... like... like............

 

[skoat]

Say, "like" one more time. Do it. See what happens.

 

[pofacedhoe]

Don't know but apparently 4-methylamphetamine has a long half life due to removing one of the potential routes of metabolism amphetamine undergoes (4-hydroxylation). If it also stops MAO from doing it's job, them all the major routes of metabolism have been stopped

i find that when i feel the speedy drug leaving a day or two after the initial 4mmcat high i get terrible wind (farts and burps) than a day later that speedy aftertaste is gone and i feel tired and bored and incredicbly hungry. is there a metabolic route that would leave me with loads of gas (more than even fizzy beer) from every end (disolved in the blood maybe)?

 

[fastandbulbous]

Nope - I find anxiety causes me to unconciously swallow air, resulting in extreme flatulence at times (esp when I used to use Psilocybe mushrooms). Most probably happens with you as well

 

[John Lewis]

Mephedrone metabolism.

looks like my earlier prediction of the paramethyl ephedrine metabolite is correct, although it also makes paramethyl norephedrine by N-demethylation.

from what I am hearing mephedrone users should expect more bad news over the following months.

please use this stuff in strict moderation if you must use it, if you can't moderate your consumption don't take it at all. It is not looking good at the moment.

Also can wemake an effort to keep the signal to noise higher on this thread. Don't post inane trip reports here, post them in trip reports. I suggest that any future off topic trip reports will be deleted

vecktor

O45. Metabolism of the new designer drug mephedrone
and toxicological detection of the beta keto designer drugs
mephedrone, butylone and methylone in urine
M.R. Meyer, F.T. Peters, H.H. Maurer
Department of Experimental and Clinical Toxicology, Saarland University,
D-66421 Homburg (Saar), Germany

Introduction: Beta keto (bk) designer drugs are a new class of drugs of
abuse. In contrast to mephedrone (2-methylamino-1-p-tolylpropane-1-one),
the metabolism of butylone (2-methylamino-1-(3,4-methylenedioxyphenyl)
butan-1-one, bk-MBDB) and methylone (3,4-methylenedioxymethcathinone,
bk-MDMA) has already been investigated. So far, these designer drugs have
not yet been included in our systematic toxicological analysis (STA).

Aim: The first aim of the presented work was to study the metabolism of
mephedrone and to incorporate all of the above-mentioned bk-designer drugs
into our STA. The second aim was to check for suitability of our rat model
by comparing incurred rat urine samples with human urine samples from
mephedrone and butylone users.

Methods: For the metabolism study, urine samples from male Wistar rats
(20 mg/kg BW) were extracted (liquid-liquid or Isolute Confirm HCX
cartridges) after enzymatic cleavage of conjugates. After extraction and
acetylation, the metabolites were separated and identified by GC–MS in
the electron ionisation and in the positive chemical ionisation mode. For
toxicological detection, a common users dose corresponding to 1 mg/kg
BW were administered to rats and urine was collected over a 24 h period.
Human urine submitted to our laboratory for toxicological analysis was
collected approximately 6 hours after intake of an unknown amount of
butylone and mephedrone. The rat and human urine samples were analyzed
using our STA based on an acid hydrolysis followed by liquid-liquid
extraction, acetylation and analysis via full-scan GC-MS. Finally, the
results from the metabolism and screening studies in rats were compared
to those obtained from the patients’ urine to verify the suitability of the
used rat model.

Results: Analysis of the rat and human samples revealed the following
main metabolic steps for mephedrone: N-demethylation to the primary
amine, reduction of the keto moiety to the respective alcohol and oxidation
of the tolyl moiety to the corresponding alcohols and carboxylic acids. The
metabolites of butylone and mephedrone detected in rat urine could also be
found in human urine samples. Using our STA, the parent compounds and
N-demethyl metabolites could be detected in rat urine after a common user’s
dose as well as in the patients’ urine samples in the case of mephedrone and
butylone.

Conclusion: Besides the elucidation of the metabolism of the new designer
drug mephedrone, we were able to show, that our STA was suitable to proof
S1-23

Ann Toxicol Anal. 2009; 21(S1) Abstracts
an intake of at least butylone and/or mephedrone in human urine. These
examples showed again that the used rat model was suitable to predict the
qualitative metabolism and detectability of drugs in human urine.
Keywords: designer drugs, butylone, mephedrone, methylone, metabolism

http://www.ata-journal.org/articles/ata/pdf/2009/02/ata2009s102.pdf

So what effects will this be having on people?

 

[bresker]

If mephedrone causes long-term vasoconstriction lasting 6 months or more, should those affected have high BP readings?

I'm not about to take my BP during a meph session, fair play to those here who can take such readings for trip reports; I don't fancy freaking myself out.

But I got my BP taken last month and it was 100/62. This was 5 days after taking a gram or so of meph/M1 mix and after taking such mixes for many months.

----------

Had my Monday night sleep paralysis/lucid dreaming at 4.00am. Restless legs, hovering between sleep & wakefuless. Because I couldn 't wake myself up I tried to control the dreams; I tried to make my unconscious sleeping self wander around the house and do mundane tasks like fold washing. But I got attacked by a golden coloured monster and a weird old man. Wasn't much fun. I got too afraid to go back to sleep and stayed awake till 5.30 to make myself really exhausted. Took a few paramol to control the restless legs but I think they may have made the nightmares worse.

Wasn't a lot of fun this time. This happens every Monday. Luckily I started work late today.

Have no desire to take any more of this substance at the moment, but then it's Tuesday.

 

[MeDieViL]

Hmm i was thinking about this long lasting vasoconstriction...

Is it possible that this is caused by some kind of sensitisation/downregulation of certain alpha adrogenic receptors? I wonder how good something like Tolazoline would work to correct the symptons.

Ive got no other explanation for this effect lasting long term.

 

[MeDieViL]

If mephedrone causes long-term vasoconstriction lasting 6 months or more, should those affected have high BP readings?

I'm not about to take my BP during a meph session, fair play to those here who can take such readings for trip reports; I don't fancy freaking myself out.

But I got my BP taken last month and it was 100/62. This was 5 days after taking a gram or so of meph/M1 mix and after taking such mixes for many months.

I dont think they had a high blood pressure (ecept the normal raise caused by a stimulant) as everything seemed to appear normal when they were hospitalized. (except looking purple).

 

[bresker]

I would have thought vasoconstriction would cause hypertension or am I missing something?

 

[MeDieViL]

I would have thought vasoconstriction would cause hyperrtension or am I missing something?

Thats the odd thing about those ppl being hospitalised, all parameters appeared completely normal.

My heart rate stayed at ~100 for eight hours, and the blood pressure and oxygen levels were apparently normal.

http://www.bluelight.ru/vb/showpost.php?p=7217937&postcount=100

Hmm maybe this guy is correct and its dermatomyositis and not vasoconstriction after all thats causing those symptons?

 

[MeDieViL]

Hmm, i think this guy may be correct about dermatomyositis.

There allways has been one report about mephedrone with a very strange effect, i never knew how to explain it. I allways tought something more then just vasoconsctriction was going on.

Here i quote the whole report:

SWIM first ordered mephedrone 3-4 months ago as pills and MDMA had turned into crunchy BZP crap.
Initially amazed by results and that it was legal.
First couple of times used up to 350mg, didnt fiend that bad and could sleep without any problems.
Then a night without sleep consuming over a gram resulted in purple knees, rapid heart beat and abit of a guilt ridden panic attack when realised it was 10.30am the following day.
The next few times consuming upto a gram noticed profuse sweating, shortness of breath, freezing cold toes and the returning of purple knees.
A morning after one of these binges SWIM noticed his left testicle was heavy, the actual ball itself has grown in size, the veins leading to the testicle were really thick and there was a small amout of fluid surrounding it aswell.
Worried by this SWIM was refered to Urology, were the doctor appeared to be just as concerned and arranged for a scan and blood test there and then.
The doctor said it wasnt a Variocele, and that although there was fluid most of the size was the ball itself.
He also asked if SWIM worked with chemicals to which he replied no. Whilst being scanned the doctor said there was fluid but not enough to be classed a Hydrocele, a couple of cysts were present but normal and that the testicle appeared normal.
When sent back to the original doctor he was surprised by the results of the scan but said this was good news as the scan would of picked up anything nasty.
The doctor decided to try antibiotics to see if it was due to infection and wanted to see SWIM again in a month and said he may scan it again.
SWIM finished the course of antibiotics without any change at all and is due to go back to the hospital in a couple of days.
SWIM was just wondering if anyone on this forum has this problem or is aware of any reason why this would happen or if it would be very unlikely a result of the Meph and is just a horrible coincidence?
Any help/explanations would be very much appreciated.

If the dermatomyositis theory is correct, we may be able to explain this side effect.

Dermatomyositis is characterized by inflammation of the muscles and the skin. If i'm correct such inflammation may cause fluid to build up which would explain this very strange side effect.

It would also explain the so called long lasting vasoconstriction, which i tought was pretty weird, and if it indeed was such a severe vasoconstriction shouldnt blood pressure go up too?

Obviously i have no idea what i'm talking about here, but its just a theory i think could be possible.

Dermatomyositis just seems to completely match all the reported symptons.

 

[ColtDan]

good point!

ive spoken to a few random people out and about who claimed of rashes, etc

it could well be causing skin conditions

 

[MeDieViL]

good point!

ive spoken to a few random people out and about who claimed of rashes, etc

it could well be causing skin conditions

If those severe symptons are indeed caused by dermatomyositis i'm guessing that those who experience rashes caused by mephedrone are at a much bigger risk to develop those severe symptons seen in some ppl.

It also makes me wonder wheter you could somehow do an allergy test to check wheter you are sensitive to this side effect of mephedrone.

IMO no doubt that vasoconstriction plays a big role too, 4 methyl ephedrine is probably very nasty in high doses, and it would only augment the bad side effects caused by mephedrone so it looks alot worse.

And again i have no idea what i'm talking about, its all just speculation.

I would personally like to find out wheter:
- Those who experienced bad side effects from mephedrone experienced rashes before.
- A vasodilator allevates the symptons ppl show weeks after taking mephedrone.

EDIT:

I've just read this report again:

Hi guys. I did Mephedrone for the fourth time today with a cumulative dosage of around 600mg (somehow...) over around 6 hours from 2am to 8am this morning. I am still confused as to how I finished the gram off since I only remember taking a 100mg bomb and a couple of lines. This morning, at around 8am, maybe earlier, I started to notice my knees turning slightly purple. I had read about that teenager who overdosed and went blue in the face. Naturally, I start worrying a lot. It became worse and worse until my knees were completely blue and my feet were going really pale. It also happened to my arms, quite severely. I started getting confused and tired. I had developed two red rashes one on my shoulder and one on my thigh. I remember watching the blue spread across my arms until i was covering the majority of the "outsides" of my arms. I kept breathing really deeply to try and slow my heart down and get more oxygen to my body. My hands were really blotchy with red and purple. My limbs had lost temperature and were pretty numb and as I looked in the mirror my ears my pale and slightly tinted blue along with my face. I looked closely and my lips were becoming blue as well. I tried to get the energy to phone an ambulance at this point as I thought that was the end of me. However, Very VERY luckily the side effects peaked and started to subside. I lay in bed breathing deeply for around 2 more hours until my limbs were nearly the correct color. Even now, 12 hours since the first dose (and the majority) and 6 since the final dose of around 50mg, my limbs do not feel right, especially my knees. If I cross my legs now my knees start going blue.

http://www.bluelight.ru/vb/showpost.php?p=7171008&postcount=28

The rashes seem to come along with this person turning blue, again this makes me think that this is not just vasoconstriction.

 

[7zark7]

Thats the odd thing about those ppl being hospitalised, all parameters appeared completely normal.

Can't remember if I have mentioned it in a previous post, but could any hypertension caused by the vasoconstriction be 'cancelled out' by the dehydration that meph seems to cause?

 

[fastandbulbous]

^ Possibly - that would also cause incredible strain/damage to the kidneys

 

[MeDieViL]

Can't remember if I have mentioned it in a previous post, but could any hypertension caused by the vasoconstriction be 'cancelled out' by the dehydration that meph seems to cause?

I cant answer that one. I'l leave that question for f&b or any other of the smart ppl here.

 

[bresker]

Not eating for long periods should also lead to a drop in blood pressure? Though this will also put pressure on the kidneys.

Though I don't get the evil, wine-dark urine on this stuff that I've experienced during major amphetimine binges.

I try and hydrate the day before, during, and after a session. I forget to during sometimes though. Dry mouth will also screw your tooth enamel.

I had a kidney function test last month and was given a clean bill of health.

 

[Bavanai]

i never do more than 250mg a session and i do it rarely (say monthly), so far it's ok, i don't get nasty side-effects, i can eat right after it and i can sleep a couple of hours after it wore off.

i think all these side effects and toxicity come from excessive abuse OR some unhealthy cuts (don't think that if it's legal it's 99% pure)

 

[fastandbulbous]

Yes but that's measured use, most people get sucked into redosing ad nauseam until they turn purple & panicky