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How toxic is Mephedrone?

Small Usage

I came to this thread hoping to find peoples' opinions on the toxicity of very rare use (i.e. 1 g every 2-3 months) which is all I do. It seems no one else does this small of an amount though? If anyone does, I would love to hear your opinions on long term (i.e. years from now) effects (i am aware that they are largely unknown).

To give more details - each time I do mephedrone, I snort about 1/6 of a gram (I weigh 180 pounds). Also, once I took 100mg of 5-HTP first to see if there was a difference, seemed pointless to do though, maybe the high lasted a bit longer. but I stick to snorted doses of 1/6 g every 3 weeks or so without the 5-htp, that's all. Would keeping up a habit like this for a few years effect me significantly ten, twenty years later? I know that's unknown, but just wondering your opinions. Thank you.
 
wilsonej30 said:
I came to this thread hoping to find peoples' opinions on the toxicity of very rare use (i.e. 1 g every 2-3 months) which is all I do. It seems no one else does this small of an amount though? If anyone does, I would love to hear your opinions on long term (i.e. years from now) effects (i am aware that they are largely unknown).

To give more details - each time I do mephedrone, I snort about 1/6 of a gram (I weigh 180 pounds). Also, once I took 100mg of 5-HTP first to see if there was a difference, seemed pointless to do though, maybe the high lasted a bit longer. but I stick to snorted doses of 1/6 g every 3 weeks or so without the 5-htp, that's all. Would keeping up a habit like this for a few years effect me significantly ten, twenty years later? I know that's unknown, but just wondering your opinions. Thank you.
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ive never done more than 1 gram to myself in a weekend, and have tried it every other weekend since the summer...... but i learnt that you shouldn't bosh it up your nose, you need to ingest it through swallowing or it messes with your mucus levels and inflames the septum. A friend of mine looked like he had a cig burn below his nose. On inspection, as it wasn't gooey :S it appeared to be a chemical burn.
 
MeDieViL said:
We all know why PMA is dangerous, mephedrone is no MAOI so its relevant wheter its a neurotoxin or not. And yeah the biggest issue with meph is the vasoconstriction anyway wich could probebly be avoided by keeping the doses around 300mg.

If it turns out not to cause serotonin depletion, it may be an allright drug in low doses.
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Do we, it's only a substrate competetive inhibitor a la amphetamine etc ie not something to get so concerned about. The main problems with PMA are due to ut's cardiovascular & temp control effects.

Think you're confusing it with 4-MTA (the sulphur analog of PMA), which is well dodgy


Alcohol does not offer a rush, and yet it is a very, very addictive substance, both mentally and physically.
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It has a very rapid onset, hence it's rapid action that leads to compulsive redosing
 
fastandbulbous said:
Has anyone suffered an insensitivity to psychedelics or stimulants after long term use of mephedrone?
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A few ppl have reported to have lost the magic to MDMA because of mephedrone use, someone else even reported being unable to feel the effects of stimulants, psychedelics and MDMA even 2 weeks after he stopped using mephedrone.

If you have a massive tolerance to MDMA, stimulants or anything else you will get blasted by meph, but seems like meph builds a very bad tolerance to those substances wich isnt a very good thing.

I'm also interested in more experiences tough.

Yeah could be i've mixed those up, i only vaguely investigated those substances in the past.
 
How much research has actually been done on 4 methyl amphetamine? According to wikipedia its less toxic then 4-chloroamphetamine but more so then the fluor compound. I have no idea where that info comes from?

Yet someone posted a study here showing that it wasnt toxic to serotogenic neurons. But from the experiences with this chemical it would seem to be a neurotoxin. (Look up the thread on this substance).
 
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fastandbulbous said:
Less toxic than 4-chloroamphetamine isn't a declaration of safety as 4-chloroamphetamine is a known neurotoxin in primates (which we are, lest you forget!) - it destroys serotonogic neurones
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Yes, i'm aware of that, thats why i would like to see the study (if it exists) were that info is based on. The reports i heared of russia also seem to point to neurotoxiticy (altough mephedrone anecdotally doesnt seem to cause such long term aftereffects as reported with 4 methyl amphetamine).

http://www.bluelight.ru/vb/showthread.php?t=419580&highlight=4-methylamphetamine

But then we also have this study:
p-Bromoamphetamine 27 and p-bromomethamphetamine 2R, 29 lower brain
serotonin to an extent comparable to the reduction caused by the corresponding
p-chloro compounds. pFluoroamphetamine decreases serotonin levels, but its
effects do not persist to the same degree as those of p-CA.27s 30 Other parasubstituted
amphetamines have less activity (trifluoromethyl, phenoxy) or no
activity (methyl, methoxy ) as serotonin depletors.20
Norfenfluramine is an analog of p-CA that bears an m-trifluoromethyl substituent
instead of a p-chloro substituent on the ring. Norfenfluramine and
fenfluramine (the N-ethyl compound) lower serotonin in rat brain for a very
long time, though they are slightly less active than p-CA.3*-34 Although Costa
and Revuelta 32 have reported that norfenfluramine increases serotonin turnover
instead of decreasing it, as p-CA does, we find that norfenfluramine causes a
rapid reduction of tryptophan hydroxylase accompanying the decline in serotonin,
just as p-CA does (TABL3E) . Sanders-Bush et al. have reported shortand
long-term depletion of serotonin and tryptophan hydroxylase in rat brain
after injection of fenfluramine.'? In general, the actions of norfenfluramine and
fenfluramine on brain serotonin neurons may be very similar to those of p-CA
and other chlorinated amphetamines.
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Nice to see the media hype has worked and panicked many people into not buying any mephedrone
 
Re-pasta, but noteworthy IMHO

Bob Loblaw said:
I think this drug FUCKED my tolerance to other serotonergic things.

I ate 3.5g of potent shrooms... barely a +
Snorted 125mg of potent Methamp... not even increased HR or dilated pupils
Railed 100mg of top-quality MDMA and did a 60mg bomb... not shit
I can snort 20mg Adderall and fall asleep right afterward
I can snort 60mg and barely feel it

These occurrences have all happened either as I was using Meph regularly or 1-2 weeks after my last dose. Hopefully in a month or two I'll be back to normal :\ :(


FFFFFFFFUUUUUUUUUUUUUUUUUU--
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Bob Loblaw said:
FFFFFFFFFFFFFFFFFFFFFFFFFFUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUUU--

Not even goddamn dopaminergic goodies work >___<
I barely feel really good blow ;__;

So, 3 weeks since my last dose, I'm going to start a regimen of:

100mg 2x daily 5-HTP (3 weeks)
l-Tyrosine (2 weeks)
Multivitamin (3 weeks)

We'll see how this pans out...
I am SO sick of only being able to get high on opiates and JWH and Ketamine ;______;


ashdjl;ashkl;djaskl;jdkl;jfffo983254890-7*()^&*)_&90-845943jkljraskldjkasl;jd
asjl;dhaskl;djhaskl;djHHHHHHHHHHHHHHHHHHHHHH
AHHHHHHHHHHHHHHHHHHHHHkl'asjhdkl;ashd
rhghgrhgrhgrh
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Also, my friends have consumed the exact same drugs (same time, same suppliers) as I have, and one couldn't feel LSD, and another couldn't feel the mushrooms. Only when we had been doing Meph had we been unaffected.
 
Media

n3ak said:
Nice to see the media hype has worked and panicked many people into not buying any mephedrone
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can't really infer what your view is. Though that is your right to know. Someone has also stated that "mephedrone is for amateurs".

While I think it's easy for some people to think that the people that have died were inexperienced like Leah Betts, for others it was a bit of a wake-up call and I can sense a recovery process among others.

As long as your lifestyle doesn't interfere with your ambition, then noone has any right to criticise.

<3
 
MeDieViL said:
But then we also have this study:
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What I really want too is that referenced study, since it may have simply been at the doses given. It's known that p-Methylamphetamine is almost 1/5th to 1/10th as potent as amphetamine, so if you're using 1mg/kg or 2mg/kg, you may not approach toxicity. But, I can't seem to find it online.

Also, my friends have consumed the exact same drugs (same time, same suppliers) as I have, and one couldn't feel LSD, and another couldn't feel the mushrooms. Only when we had been doing Meph had we been unaffected.
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That would be some weird neurotoxicity, even the people I've known with severe 5HT damage from meth or MDMA still respond to psychedelics. Amphetamine does not generally get them high though, or provides a kind of lackluster caffeine-like high.
 
Bob Loblaw said:
Re-pasta, but noteworthy IMHO

Also, my friends have consumed the exact same drugs (same time, same suppliers) as I have, and one couldn't feel LSD, and another couldn't feel the mushrooms. Only when we had been doing Meph had we been unaffected.
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Bob - that's odd. When I was using mephedrone I would go through 2-3 grams (tops of 400mg a sitting) over a few weeks, and at the end of those weeks I would trip (some strange rationalization about the healing power of psychedelics, I can't give you a better reason than that). A 15mg dose of 2C-I that I would normally barely get visuals from felt more like 25mg, DMT breakthroughs became very easy...

wierd.
 
Bob Loblaw said:
Also, my friends have consumed the exact same drugs (same time, same suppliers) as I have, and one couldn't feel LSD, and another couldn't feel the mushrooms. Only when we had been doing Meph had we been unaffected.
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Hmmm... both acid and shrooms can be a bit weird at times. Set and setting can have both an enhancing and diminishing effect on psychedelics like these. ;)
 
Yes, but when you have mushrooms grown by professionals (growers and hippies- they fungus was cultivated with love and positive energy), the seller( and very honest friend) said after we purchased, that batch was the second most potent he's tried. And that's really saying something. He recommended 2g and another seasoned tripper (much mush experience) said don't start with more than 2.5g. I've taken 1.75g and then an hour later 1.75g of normal mushrooms and tripped MUCH harder than this.

Also the night I was doing meth, I did 125mg of quality product (dose recommended by neutral friends was 75-100mg) and got nothing. I then busted out the Meph and got high proper.

Just this evening I tried more coke and certainly felt something, though I was dosing rather high, and with potent product.
 
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