How to pre-dose with 5Htp

[barrypepper]

Its been a good few months since I last took mdma, but in the past 2 weeks I've been going a bit over the top with Mephedrone. Gone through about 2-3 grams. And I'm planning on taking MDMA again this weekend, but I want it to be a goon un'.

I understand some people have had success pre-loading with 5Htp to increase serotonin levels. I also believe that increased serotonin levels in the brain over a few days can lead to down-regulation of 5ht receptors, which would be counter-productive.

So two questions really, will the mephedrone I've been taking actually have effected Serotonin levels/receptors significantly? And when is the best time to take the 5htp (on an empty stomach with green tea extract....), the day before the mdma, the morning of it, or a few hours before?

 

[pothole]

I've only taken 5htp after doing mdma to help with the comedown. Always thought it was a bad idea to preload as it lessons the mdma effects. I suppose you can take it up to a couple of days beforehand as 5htp doesn't stay in your body too long.

 

[barrypepper]

I've only taken 5htp after doing mdma to help with the comedown. Always thought it was a bad idea to preload as it lessons the mdma effects. I suppose you can take it up to a couple of days beforehand as 5htp doesn't stay in your body too long.

I wouldn't want to take it a few days before hand because of my worries that excessive serotonin would downregulate receptors.

 

[barrypepper]

I've just been doing a bit of reading of anecdotal reports, and it seems using H5TP within a few hours of the MDMA WILL diminsh the high, but taking it the day before wouldn't?

Does anyone know the Science behind this? My laymans guess is that if taken long enough before the MDMA, the "added" serotonin will have been "reuptaken" to the receptors from which it is released. With the massive release of serotonin from these receptors being responsible to the MDMA high, I guess this would boost the high. But taking the 5HTP too close to the MDMA dose will mean the added serotonin will still be in the snyaptic spaces, yet to be "repultaken" thus lessening the effects of the MDMA serotonin released from the receptors?

 

[Folley]

Mephedrone and MDMA will have a highly significant cross tolerance, as will almost ALL stimulants. Not really anyway around it, and that certainly includes taking more pills.


I would recommend staying away from 5-HTP myself and instead supplement with a healthy diet high in L-Typtophan and other nutrients, but that's just what I do.




You ought to look over this thread:
http://www.bluelight.ru/vb/threads/407429-Mega-Harm-protection-supplements


Yours may be moved into there later anyways

 

[ROLLINBISCUIT]

Mephedrone def will diminish the roll. One time i went on a m4 bender an stayed up all night doing it with friends. Killed a couple grams. Then the next night I went to a show. I took a tenth of tested molly and barely felt ANYTHING. All my friends were rolling on the same shit but I still had fun cuz the show was kickass. In conclusion you can try an roll but if you have been abusing mephedrone you totes will experience a diminished roll.

 

[barrypepper]

Mephedrone def will diminish the roll. One time i went on a m4 bender an stayed up all night doing it with friends. Killed a couple grams. Then the next night I went to a show. I took a tenth of tested molly and barely felt ANYTHING. All my friends were rolling on the same shit but I still had fun cuz the show was kickass. In conclusion you can try an roll but if you have been abusing mephedrone you totes will experience a diminished roll.

I won't have been up all night on an all night bender the night before though. I'll have had 3 days off of healthy food and exercise, and a few good nights of sleep. And I'm supplementing with anything that might help.

I'll also be taking much more than a 1/10th of a gram of MDMA, if that's what you meant.