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Opioids How to get optimum analgesia with IR meds? Chronic dosing question.

tricomb

tricomb

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Jan 21, 2012
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Some opioids, like methadone, are taken in a Chronic Dosing schedule, which means, several times a day, to maintain proper analgesia.

So my question is, with other opioids, like hydromorphone, morphine, and oxycodone:

Do you get better analgesia by taking, for example (lets make this simple) , your supposed to take 20mg oxycodone every 4 hours. Is it better to take 20mg q4h as prescribed,

OR:

Chronic dosing: take your 20mg, split it into doses of 1 x 10mg, and 2 x 5mg. Take the 10mg part, then after 1 hour, take another 5mg, then after another hour, take the other 5mg. Yes, you are in more pain while you're waiting for it to kick in due to taking a lower dose.

I'm wondering because in terms of intoxication, when I do chronic dosing, I get wayyyyy more intoxicated, but it takes longer to feel the intoxication, because you're slowly raising the dose, but I get much better analgesia AND euphoria with chronic dosing of morphine, hydromorphone, methadone, or oxycodone, rather than taking a bigger dose all at once and having it hit you hard in 15-30 mins.

Basically doing chronic dosing IMO gives me better analgesia by taking my next dose as soon as I feel my previous dose peaking, trying to mimic an ER medication.

My question is about analgesia, but any experiences with abuse/intoxication will help too. Thankyou :)
 
Wow, just asked similar question like a minute ago in the PM thread. Like minds think alike?

I tend to think with chronic dosing that you are more likely to achieve better analgesia but worse euphoria simply because I tend to think that with most opioids, in terms of euphoria, that a person must somewhat 'come down' for that person to be able to feel any euphoria whatsoever going back up.

Just my .02, not sure which way the majority of BLers would go though.
 
I feel when it comes to analgesia, I think taking the prescribed dose at once is the most optimum, IMO, thats my experience anyway since I don't like waiting for it to kick in when I need it the most. If your splitting the dose's, wouldn't you have to account for the half lives? The split dose would be out of your system sooner than the full dose.?
But

I also do chronic re-dosing as you do, but I only do it to feel the euphoria of Ex. Oxycodone. I usually do lets say 15mg every 20-25min to get where I want to be instead of doing it all at once. As you say Its much more intense and last longer, I find that to be very true, especially with snorting, I like to drag it out a little bit, not hours. maybe 1.5-2hours.
 
I've actually found that I get much more euphoria from chronic dosing than one large dose, it's just that you have to be patient enough to let it creep up on you.

Yes, the point of chronic dosing is partly based on half life. That's why we do chronic dosing, to add more to supplement the previous dose, factoring in it's half life/speed of elimination.

I've done chronic dosing at various different time intervals and with many different opioids and ROAs, like I used to snort a bit of opana every hour even though it was still going strong, and it would drastically reduce pain levels, in addition to the euphoria.
 
I get more euphoria when j chronic dose with oxymorphone. Its like a build up and feel the best at nite in terms of euphoria
 
Jacksterini said:
I get more euphoria when j chronic dose with oxymorphone. Its like a build up and feel the best at nite in terms of euphoria
Click to expand...

Yeah I got mind-fuck levels of euphoria with OM chronic dosing intranasally.

I've been doing chronic dosing for the past four hours, adding 5mg oxycodone at a time, I'm at 40mg now and it feels like I just railed a whole 80mg all at once, and I've been able to maintain optimum analgesia and euphoria for the past four hours!!! My pain levels are minimal today, I'm pretty convinced that chronic dosing is the way to go. If I had dosed it all at once four hours ago, I am sure I would have gotten rapid analgesia, but by now I would not be feeling any relief.

I've experienced similar effects from chronic dosing of hydromorphone and morphine, and of course methadone.

Right now my pain management doctor won't put me on ER medications (Morphine ER is what I should be on), so I have to use what's available to me to mimic an ER.
 
When I have to use my prescribed oxycodone hcl I prefer to take 7.5 every 3-4 hours
Even though it doesnt feel like feel like the pain killing properties have 'built up' by night-time It works better for the pain, compared to trying to use 30 mg's every 6-8 hours. Even though, as I have stated previously, pure Bupe
(small amount) does help considerably w/ the rebound effects.
 
I am also on IR only meds for my pain management. I feel that chronic dosing works well with oxymorphone, but poorly with the shorter-acting opiates, especially hydromorphone.

It should work best with the -codones with the previous dose acting as a potentiator (through enzyme regulation), making the drug both last longer and feel stronger.

Sometimes I do chronic dosing, sometimes I just dose pnr taking one dose at a time. Taking the dose as prescribed (all at once) certainly leaves me with a longer "tail" where the euphoric effects are gone and its just mostly analgesia and a much clearer mental state. Chronic dosing makes me just feel like I am getting higher and higher and higher, and oftentimes I even puke from it. Definitely gives great analgesia, but I find it hard to function.
 
Chronic dosing is pretty much the way to go for pain patients, and any abusers who have the patience necessary. (Which excludes just about everyone using ROA's other than oral)

I first noticed that chronic dosing was working very well with (duh) methadone, then oxymorphone, then all the other opiates.

It works with hydromorphone too, but you need to dose even more frequently.

Right now, I'm taking 30-60mg DXM/day before I take my oxycodone and/or methadone, with hydromorphone for BT. I've completely weened myself off my LONG addiction to opana. (yay me!) I can still get the 5 and 10mg IR but I don't want to have to pay for that, they're more expensive than other cheap opioids, like methadone/HM/OC.

What I do, (the OP I made was using 20mg oxycodone as an example to keep the numbers simple) is pop a larger dose to begin with, like say, 30mg oxycodone, then resume chronic dosing in smaller amounts, and honestly, it works just fine and dandy!
 
I've been using it for less than a week, so I don't really know what to expect.

There are also other factors, I'm not on a stable dose of opioids right now, as I have been weening off opana, and down on methadone, etc.

But yes, I have noticed a pretty significant improvement when dosing my oxycodone, and I usually don't have anything nice to say bout oxycodone, but it's been doing pretty good for analgesia. Now if only I could get more than 2 hour of analgesic duration =\

FTR: NMDA antagonists don't lower your tolerance, they just try to prevent it from increasing further.
 
It has amazing potential...first time, 30 years ago, my vacation Doc' wrote me a script' for the .25 mg. sublinguals but I also had scripts for Percocet & Vicodin so I didnt think it was anything. (12 yrs. later) on vacation he explained to me how it works & to try
the .25 ampules w/ the over the counter ultram. Two IM injects' + 2 ultrams later I was amazed.
 
For the same reason you are using the DXM, but most Doctors dont know anything about that aspect of Bupe' so it might be hard to reason, unless he is very educated on it...Mostly for
anti-rebound effects, for lack of better expression (you dont feel the need to re medicate so abruptly)
 
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