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How similar is Methoxetamine to 4/3-meo-pcp?

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bigcol75

Greenlighter
Joined
Aug 3, 2011
Messages
18
I read somewhere that Methoxetamine is as closely related to PCP as it is to ketamine. How do these PCP analogs compare to Methoxetamine in terms of experience? Also, I've developed a fair-old tolerance to Methoxetamine (1g in a few days), Is there likely to be any cross tolerance? Cheers, cleverer people than me!
 
MXE
Name: Methoxetamine
Chemical Name: 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone
Alternate Chemical Name 1: 3-MeO-2-Oxo-PCE
Alternate Chemical Name 2: 2-(ethylamino)-2-(3-methoxyphenyl)cyclohexan-1-one
CHEMICAL FORMULA: C15H21NO2

PCP
Name: Phencyclidine
Chemical Name: 1-(1-phenylcyclohexyl)piperidine)
Alternate Chemical Name: Phenyl Cyclohexyl Piperidine
Chemical Formula: C17H25N

Ketamine
Name: Ketamine
Chemical Name: 1(RS)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
Chemical Formula: C13H16ClNO

Ketamine, Methoxetamine and Phencyclidine can produce a dissociative state by exerting its pharmacological action through inhibition of NMDA receptors. Heavy use of MXE, PCP or Ketamine will produce tolerance, dependence and withdrawals. The three substances can be considered as cross tolerant.

Methoxetamine has been described as a "less euphoric version of Phencyclidine. That it does not hit his pleasure recptors as strongly as Phencyclidine, but does cause the same paranoia, mild hallucinations and otherworldly experiences." Methoxetamine does not, one must note, induce anaesthesia unlike it's brother Ketamine and its cousin Phencyclidine. MXE also can be very fiendish and habit forming because, as well as being an NDMA agonist, it binds quite strongly to the Mu opiate receptor. Low doses have more qualities to that of taking opiates, while delving higher on the MG scale it gets greatly more psychoactive.

It must be noted that an opiate tolerance will reduce the opiate reaction from MXE.


The Hole:

"At sufficiently high doses of the drug ketamine (often 0.25 grams (0.0088 oz) to 0.5 grams (0.018 oz) or more), it is common to experience a "K-hole". This is a slang term for a subjective state of dissociation from the body which may mimic the phenomenology of schizophrenia,[1] out of body experiences or near death experiences,[2] and is often accompanied by feelings of extreme derealization, depersonalization and disorientation, as well as temporary memory loss and vivid hallucinations."

"Methoxetamine allows one to maintain a bit more clarity of thought throughout the experience as compared with Ketamine, making it easier to process and remember the insights one has throughout the experience. The euphoric component was also a nice addition. MXE also has a longer duration than Ket, which could be a plus or minus depending on what one is looking for."

Phencyclidine is very similar in its chemical make-up to PCP Ketamine but is longer acting and more toxic.


Ehhh, thats enough food for thought.
 
Thanks tripman, that is indeed enough food for thought. Any ideas what heavy use of NDMA antagonists might produce in terms of side effects? I tend to feel right 'on top of my game' while using them (high or not) but, tbh, don't really understand any longer term implications. Cheers.
 
bigcol75 said:
I read somewhere that Methoxetamine is as closely related to PCP as it is to ketamine. How do these PCP analogs compare to Methoxetamine in terms of experience? Also, I've developed a fair-old tolerance to Methoxetamine (1g in a few days), Is there likely to be any cross tolerance? Cheers, cleverer people than me!
Click to expand...

Methoxetamine's chemical structure was specifically chosen for use because of its similarity to ketamine. I mean just take a look at the molecules, you got that cyclohexanone and the amine and what not (note: I don't know shit about chemistry, was trying to look up what parts of molecule were called as I was doing this), whereas unsubstituted PCx's have cyclohexylamines. Also, assuming the title is the question, 4-MeO-PCP and 3-MeO-PCP are different enough that trying to compare another dissociative to them both at once would be fruitless.

In your research into possible replacement dissociatives you'll have to consider dose:cost ratio (4-meo-pcp requires rather large doses), exactly what aspects of MXE you enjoy, and what other dissociatives have these elements, and other factors. You should also consider that given anecdotal evidence, dissociative tolerance may very well be permanent, or at least last for years, so escalating your dose continuously is rather dumb if you want to be able to enjoy these drugs in the future. Take longer breaks between doses, preferably take a few months off right now till your next dose, at least one, and continue using at a rate of no more than once or twice a month. High doses of these drugs like you're taking can have significant psychological impact on the user, and it may very well not be friendly (though it'll likely clear up within a week or two after you stop taking them).

Anyway, if you want to look into different dissociatives, head on over to the relevant big and dandy threads and start reasearching them!

PS - A much larger portion of people seem to enjoy ketamine and methoxetamine than seem to enjoy dissociatives in general, so keep in mind that nothing available that you attempt to replace them with will really be a replacement like say heroin would be for an oxycodone user. NMDA antagonism in itself does not make a recreational drug, all the other receptor targets significantly flavor the drugs, or so it appears anyway.
 
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