how oxycodone, hydrocodone, oxymorphone are different from heroin

[CuriousCub]

Is there a way to simplistically tell how all of these opiod antagonists work differently from each other, and ultimately, from heroin?

 

[t3knology]

first off i think that u mean opiate-agonist

an antagonist is the opposite

buuuutttut.. heroin is diacetyl morphine i believe and its just a different form of the alkaloids in opium

heroin on the street tho isnt pure..

if this helped at all, im glad, heh

 

[Orlando]

Are you asking about chemistry, effects, or something else? Are you asking from an academic standpoint, or do you want to know how to distinguish one from the other on the street?

 

[day_for_night]

heroin is diacetyl morphine i believe and its just a different form of the alkaloids in opium

this isnt correct. heroin is not found naturally. it has to be manufactured using morphine from opium.

 

[Negro-kitty]

While your elaboration is correct, d4n, t3k's comment that 'heroin is a different form of alkaloids in the poppy' isn't technically wrong. Make 'alkaloids' singular ('alkaloid') and you have morphine of course...which can be made into heroin just as you say. Heroin really IS just a different form of morphine. But t3k never implied that heroin was naturally occurring.

Opiates (and most opioids -- drugs that feel and are used alot like opiates but aren't technically opiates) act on certain opiate receptors (mu, kappa, and delta). For info on these, check out this site: http://www.bio.davidson.edu/courses/anphys/1999/Self/OpiateReceptors.htm

Most strong opiates (fentanyl, morphine and all the drugs you listed) have a significant effect on mu receptors, and this receptor interaction is responsible for their painkilling ability as well as euphoria.

 

[Partykid12]

Those are all from the technical standpoints of it, but if you want to know like the difference in the high then I think that Oxycontin is basically the same feeling as you get from Heroin. Hydrocodone is not as euphoric I dont think and does not last as long. I also find that Oxycodone and Heroin are harder on your stomach than Vicodin, you get more nausea sometimes than you would normally get from a Hydrocodone dosage.

 

[Spazz]

Is there really such thing as Oxymorphone?

 

[Negro-kitty]

^^^
Ever heard of GOOGLE??? *sheesh*

Good point re: recreational effects and differences.

I've never had the pleasure of trying oxymorphone, but as for the others:

Heroin is by far the most euphoric for me. It is also the only opiate I have ever injected, and I have never done heroin any other way, so I'm not sure how accurately I can compare it to other opiates that I've only taken orally.

Oxycodone is similar to heroin but not as euphoric...and it gives me far more nausea than heroin. Also it lasts about 1/4 of the time that heroin lasts if even that long...not really worth it IMO.

Hydrocodone is about the same as oxy in terms of euphoria, but occasionally gives me a headache. The nausea is not nearly as bad as oxy's but it is there, unlike with heroin.

So yeah...heroin all the way, baby.

 

[CuriousCub]

Are you asking about chemistry, effects, or something else? Are you asking from an academic standpoint, or do you want to know how to distinguish one from the other on the street?
=======

chemisty first, then effects. I'm interested in knowing how they all work and are MADE differently, because the different effects result from this.

Since you brought it up, and since drugs do vary in every way from region to region, i would like to know how to generally distinguish them on the streets. I think that's quite important to know.

Those are all from the technical standpoints of it, but if you want to know like the difference in the high then I think that Oxycontin is basically the same feeling as you get from Heroin. Hydrocodone is not as euphoric I dont think and does not last as long. I also find that Oxycodone and Heroin are harder on your stomach than Vicodin, you get more nausea sometimes than you would normally get from a Hydrocodone dosage.

If it's basically the same feeling, then why are they so chemically different?
What makes hydrocodone less euphoric? Why are oxycodone and heroin harder on stomach than Vicodin?

What makes the the codones more nausea inducing than heroin?

Most strong opiates (fentanyl, morphine and all the drugs you listed) have a significant effect on mu receptors, and this receptor interaction is responsible for their painkilling ability as well as euphoria.

How can fentanyl be an opiate if it doesn't have any morphine in it? Wouldn't it be an opiod?

 

[CuriousCub]

first off i think that u mean opiate-agonist

an antagonist is the opposite

buuuutttut.. heroin is diacetyl morphine i believe and its just a different form of the alkaloids in opium

heroin on the street tho isnt pure..

if this helped at all, im glad, heh

Oops.
So how is an opioid agonist different than an opiate agonist, and how important is the placement/use of a hyphen when stating those chemical classes?

by the way, I'm seeing that antagonist and agonist are synonymous, and agonist is merely the abbreviated form of antagonist, so i don't know how mistaken I was:

Main Entry: ag·o·nist
Pronunciation: 'a-g&-nist
Function: noun
Etymology: Late Latin agonista competitor, from Greek agOnistEs, from agOnizesthai to contend, from agOn
Date: circa 1623
1 : one that is engaged in a struggle
2 : [from antagonist] a : a muscle that is controlled by the action of an antagonist with which it is paired b : a chemical substance capable of combining with a receptor on a cell and initiating a reaction or activity; compare ANTAGONIST 2b

 

[Negro-kitty]

In neurobiochemistry:

-an agonist STIMULATES a receptor or autoreceptor -- thus, you usually get more effects and/or increased levels of say, dopamine, if you take a dopamine agonist

-an ANTagonist INHIBITS a receptor of autoreceptor, decreasing activity in the system, and doing exactly the opposite of an agonist

So agonist and antagonist are not synonomous but rather opposites.

And the hyphen isn't necessary. Opiate agonist or opiate antagonist is just fine.

 

[CuriousCub]

then what's the deal with the dictionary indicating similarities?

 

[two wobinas over the cuckoos nest]

i think it meant compare the differences not the similarities