Stimulants How much methylphenidate (ritalin, oral) to get a decent amount of stimulation, energy boost?

[JohnBoy2000]

I'm assuming something like mirtazapine taken concurrently with methylphenidate would not be known to potentiate it? (as it does with other NRI's like atomoxetine or effexor, where mirtazapine markedly increases the noradrenaline release)

But, basically to get a cognitive/energy boost, how much ritalin would one taken normally to see effect here?

20 mg minimum I'm thinking?

I know it and other stims like amphetamine can be prescribed to both chronic fatigue patients and patients with other conditions that precipitate chronic fatigue (such as cancer), to give them an energy lift.
But I'm unfamiliar with the doses in routine clinical practice for this purpose.

Thoughts?

 

[negrogesic]

Im not 100% sure what the question is here precisely, but I would say that mirtazapine neither increases nor decreases the effect of methylphenidate. I used to take the combo for years.

10mg of methylphenidate is sufficient to wake someone up, although it is fairly short lasting. Best taken multiple times a day (in the instant release form).

Personally I used to take 10mg of focalin (dextromethylphenidate) 4 times a day (always intranasally). This is while I was on 45mg/day of mirtazapine.

I was also prescribed a transdermal methylphenidate patch called daytrana, except i stuck it my mouth for buccal absorption.

Eventually the two produced a degree of stimulant psychosis. Which was interesting because I slept fairly normally each night (so sleep deprivation wasnt involved).

 

[Dextro .45]

ED-50 for Methylphenidate is about 0.25mg of HCL salts per Kg of body weight

Effective Dose to inhibit 50% of DAT

Adult male, the standard is usually 20mg tablets X 3 daily (lasting 3-4h each IR tablet)

1st time taking Ritalin (Methylphenidate) a 20mg IR dose made me feel euphoric. After 5 years of regular on and off usage 60-70mg IR is decent enough combined with alcohol

Taking Methylphenidate with a meal enhances absorption, more importantly consuming Ethanol with Methylphenidate increases levels of d-MPH (Focalin) by 40% ...the active isomer of racemic Ritalin...significantly enhancing the euphoric/pleasurable subjective effects in all study participants

Bacon egg toasted sandwich....then Ritalin 20-40mg depending on body weight....then Rum/Jin & coke/OJ ....2.oz each drink.....2-3 cocktails and you'll have the highest levels of dextro-threo-Methylphenidate HCL in your bloodstream / CNS

I'd try a 10 or 20mg first if you're not stimulant tolerant and low body weight 150lbs

 

[Esperighanto]

At ~200lbs I've found 20mg of IR to be sufficient orally, ~15 intranasally, but for some reason 4-Fluoromethylphenidate is a completely different beast, twice as strong orally and ~4 times as strong intranasally. Once a 23mg oral dose kept me awake for 18 hours, which even half a gram of speed insufflated and eaten can't do.

Methylphenidate synergizes well with amphetamine, it feels like it lubricates amphetamine's engine in a peculiar way, but be sure that if you ever try this to cut the doses in half because they do exhibit cross potentiation and it's better to start small and decide on a redose later, than to jump in too dramatically and maybe fuck up.

Edit: I found this citation that claims methylphenidate inhibits the enzyme CYP2D6: Cozza KL, Armstrong SC. The cytochrome P450 system: drug interaction principles for medical practice. Washington (DC): American Psychiatric Publishing; 2001.

Mirtazapine is also metabolized by this same enzyme. They will run the chance of competing for the enzymatic substrate, leading to potentially unexpected experiences (whether in quality or potency). Be careful of the mix imo, ease your way in and feel it out because mirtazapine seems like a complicated beast. Acid, amphetamines, promethazine, many beta blockers, and most classical opiates (morphinans, oddly including DXM) are all also broken down by CYP2D6.