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  • BDD Moderators: Keif’ Richards

Benzos how long on benzo before withdrawal?

Hello, could you please tell me more about the Zoloft and how does it affected your life, i mean how long do u take it, what was your starting dose and what u felt after taking your first pill and how do u feel now when u take 100mg / how do u feel if you don't take it for a two/three days ?
Can u compare it to another typical AD (if) u were taking any before and does it affected your weight and is it more on sedative or more on stimulating part of the spectrum ?
I am asking because i have it and i found many articles claiming it's not only pure SSRi ( like Citalopram ) but it's actually selective serotonine AND DOPAMINE reuptake inhibitor which basically distinguish it from all other SSRi and SNRi meds. I am asking because in my case even the maximal daily dose of escitalopram ( pure SSRi) never provided any therapeutic benefits just after few months of taking it.

( Now i take vortioxetine - Brintellix which is an atypical ad raising serotonine less than citalopram but through Its modulation of serotonine receptors it also raise other, mostly pro-cognitive things like dopamine and it Is working without loosing effectivness for a few years ).

I am also prescribed mirtazapine which i use as a sedative by taking 7,5-15mg or as motivation and energy enhancing additional atypical ad when i take 45 mg.
I always take it before sleep but when i take 45 mg i always wake up rested, motivated to actually wake-up from bed feeling it also raised my noradrenaline and dopamine and combined with vortioxetine it makes me feel somehow balanced, like if dopamine-noradrenaline-serotonine were in the perfect balance.

So this Is why i am interested about Zoloft.
zoloft takes about 3-4 weeks to start working. The starting dose is between 50mg-100mg. I started at 100mg and it helped with 50% of my GAD and chronic pain syndrome issues (not pain). Once I started taking it with Busbar (after 2 weeks) this really started to improve. I have much much less deep heavy exhale sighs, I am able to focus on routines, and I am able to complete more goals & overall much more interested in my life's tasks.

No issues with weight for me.

Zoloft alone is not enough for me. with Busbar I am having good results.
 
Sounds good if it's safe
Not particularly. But.. I can’t say I have the actual personal experience to give any real advice other than never try to get it and do it alone. And never drink on it as well. Though.. many do.

I was told by many that used it that it,
GHB, can go from good time to passed out to dead due to the dosing being finicky.

Someone correct me if I’m wrong please?
 
Steep dose response curve, so safe when used safe

Its been illegal for ages
Mm.. I’m not trying to dig at you… but if I were asking about a new drug I hadn’t heard of and someone gave me the response you just gave lostweekend… I’d be wildly confused.

How many ml is a light/medium/high dose?
What are the effects?
How do you know when it’s too much?
Etc..

Know what I’m saying? :)
 
Mm.. I’m not trying to dig at you… but if I were asking about a new drug I hadn’t heard of and someone gave me the response you just gave lostweekend… I’d be wildly confused.

How many ml is a light/medium/high dose?
What are the effects?
How do you know when it’s too much?
Etc..

Know what I’m saying? :)
Yep, today safest get Xyrem prescribed. Not gonna happen.
The only not DIY GHB i used was when you could get it Pharmaceutical.
Quality fro South-Africa, they add a measuring spoon ⚠️

Well i bought a diamond scale fore-hand and assure you.
Throw away the measure spoon, but this was 100 % pure.
You need a scale, 1.2 gram might be your dose 1.4 mine.
[the spoon when measured on a scale is wrong !]

it s not a new drug Henri Laborit who made it, in 1874.
a French surgeon, neurobiologist, writer and philosopher.

Today, i seen em never took one, people always s had GHB or GBL.
In little plastic tubes. Crazy like taking bath tub Meth.

Now a day s would you buy GHB, go to a test centre.
As there is no indication. Of dosage.
Was it made with crude material industry grade material.
Or food grade. Its now done by criminal s and moron s.
Lets say that is a good start point.

Sorry maybe i came over a bit lacking in the danger.
So i apologise, didn t realise current situation and dangers.
Especially now it s illegal.
The whole area around me is addicted to it.

Always work up and 1-st time i advise start super low,
and stop that day. Don t combine, especially not with depressant s.
After you got it tested.

And remeber there is no medical help, they to dumb.
To realize GHB is in their medicine cabinet, so can wean addict s.
Internal, in a clinic, here they have you bring you bath tub shit.

Xyrem = GHB addiction dr , no medical dr knows its GHB.
Does anyone know why dr s don t know the GHB they have is GHB ?
 
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Not particularly. But.. I can’t say I have the actual personal experience to give any real advice other than never try to get it and do it alone. And never drink on it as well. Though.. many do.

I was told by many that used it that it,
GHB, can go from good time to passed out to dead due to the dosing being finicky.

Someone correct me if I’m wrong please?
A pure GHB coma is dangerous but in general not deadly AFAIK.
But i forgot these day s people don t go to internet, test centre s.

"Overdose of GHB can sometimes be difficult to treat because of its multiple effects on the body. GHB tends to cause rapid unconsciousness at doses above 3500 mg, with single doses over 7000 mg often causing life-threatening respiratory depression, and higher doses still inducing bradycardia and cardiac arrest. Other side-effects include convulsions (especially when combined with stimulants), and nausea/vomiting (especially when combined with alcohol).

The greatest threat to life due to GHB overdose (with or without other substances) is respiratory arrest.Other relatively common causes of death due to GHB ingestion include aspiration of vomitus, positional asphyxia, and trauma sustained while intoxicated (e.g., motor vehicle accidents while driving under the influence of GHB). "


So a sober sitter is solid advise.
And writing down dosing and times !

And they indeed drink Ethanol and take GHB, add some Ketamine.
Deadly. A OD on GHB is possible, but have to check that.
Sad kid s these day s and dr s don t use all info available to them.
 
A pure GHB coma is dangerous but in general not deadly AFAIK.
But i forgot these day s people don t go to internet, test centre s.

"Overdose of GHB can sometimes be difficult to treat because of its multiple effects on the body. GHB tends to cause rapid unconsciousness at doses above 3500 mg, with single doses over 7000 mg often causing life-threatening respiratory depression, and higher doses still inducing bradycardia and cardiac arrest. Other side-effects include convulsions (especially when combined with stimulants), and nausea/vomiting (especially when combined with alcohol).

The greatest threat to life due to GHB overdose (with or without other substances) is respiratory arrest.Other relatively common causes of death due to GHB ingestion include aspiration of vomitus, positional asphyxia, and trauma sustained while intoxicated (e.g., motor vehicle accidents while driving under the influence of GHB). "


So a sober sitter is solid advise.
And writing down dosing and times !

And they indeed drink Ethanol and take GHB, add some Ketamine.
Deadly. A OD on GHB is possible, but have to check that.
Sad kid s these day s and dr s don t use all info available to them.
Thanks dude!
This is excellent information to have. I appreciate you posting it!
:)
 
Thanks dude!
This is excellent information to have. I appreciate you posting it!
:)
Sent you a pm after, still have not re-read my reply. Thank s for pointing it out.
Do you feel i should change that reply, or delete it ?
I gonna feed my body first.

Kid s overhear are atm going to shit cause of GHB a.o. coupled with,
a failing medical addiction system. Dr s know shit, they don t know Xyrem is Pharmaceutical GHB. They can use for a sfae inpatient DETOX.

So they could have stopped making it so easy still to get the precursor.
Legalised it, or illegalise, but offer a adequate treatment.
So including therapy and after care. Saddening knowing.

Told dr/ addicton people, they had to look up Xyrem, to wow
He is right. Its indeed a prescribed med. sad but true.
 
Sent you a pm after, still have not re-read my reply. Thank s for pointing it out.
Do you feel i should change that reply, or delete it ?
I gonna feed my body first.

Kid s overhear are atm going to shit cause of GHB a.o. coupled with,
a failing medical addiction system. Dr s know shit, they don t know Xyrem is Pharmaceutical GHB. They can use for a sfae inpatient DETOX.

So they could have stopped making it so easy still to get the precursor.
Legalised it, or illegalise, but offer a adequate treatment.
So including therapy and after care. Saddening knowing.

Told dr/ addicton people, they had to look up Xyrem, to wow
He is right. Its indeed a prescribed med. sad but true.
I’m not a mod anymore, but I don’t think anyone would mind if I suggested that maybe you edited your original “safe post” to say something like “but that was back X years ago, I added some info down below”.

Someone could stop reading at “it’s safe” and drink 4 bottles. Doubtful lol but crazier things have happened 😅
 
GHB is all you would like Ethanol to be. pretty non toxic.

It's probably completely nontoxic. I think it's the only common gabaminergic that doesn't cause memory impairment in modest doses.


GHB and Oxybate Salts: Less Memory Impairment Than Other Gabaminergic Drugs, But Risks Exist


Comparative Cognitive Effects

Evidence indicates that GHB (gamma-hydroxybutyric acid), sodium oxybate, and potassium oxybate generally cause less memory impairment than other gabaminergic substances such as benzodiazepines. In controlled studies, sodium oxybate produced less impairment in psychomotor function, working memory, and episodic memory compared to triazolam (a benzodiazepine), even at doses with similar subjective effects[2]. This suggests a lower risk of acute amnesia or cognitive disruption under typical clinical dosing.


Dose and Use-Dependent Risks

 • Clinical Use: Systematic reviews find no indication of cognitive impairment after clinical (therapeutic) use of GHB/oxybate salts[1].

 • Recreational/High-Dose Use: Moderate recreational use can cause short-term cognitive impairment, and chronic high-dose use or repeated GHB-induced comas are associated with long-term, possibly irreversible, memory and learning deficits—similar to other GABAergic drugs[1][3].

 • Mechanism: GHB acts as a weak GABAB receptor agonist, and its neurotoxic/cognitive effects are more pronounced at supratherapeutic doses[3][4].


Summary Table: Memory Impairment Risk

Substance/Use ContextMemory Impairment RiskNotesCitations
Clinical GHB/OxybateLowNo significant impairment[1][2]
Recreational/High-dose GHBModerate to HighAcute and long-term deficits possible[1][3]
Benzodiazepines (e.g., triazolam)HighGreater impairment than GHB[2][3]


Conclusion

GHB, sodium oxybate, and potassium oxybate are less likely to cause memory impairment than other gabaminergic drugs when used clinically, but high or chronic recreational use can still result in significant cognitive deficits. Caution is warranted, especially outside of medical supervision.


This information was sourced and synthesized using Consensus, an AI-powered search engine for research.


References

1. (2021). Cognitive Impairment Following Clinical or Recreational Use of Gammahydroxybutyric Acid (GHB): A Systematic Review. Current Neuropharmacology, 20, 809 - 819. https://doi.org/10.2174/1570159X19666210610094352

2. Carter, L., Griffiths, R., & Mintzer, M. (2009). Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers. Psychopharmacology, 206, 141-154. https://doi.org/10.1007/s00213-009-1589-1

3. Sugnet, T., Jonovska, S., & Šendula-Jengić, V. (2021). Amisulpride Reduces Craving in Patients with GBL Addiction - Case Series and Review of the Literature. Psychiatria Danubina, 33 Suppl 4, 1235-1237.

4. Pardi, D., & Black, J. (2006). γ-Hydroxybutyrate/Sodium Oxybate. CNS Drugs, 20, 993-1018. https://doi.org/10.2165/00023210-200620120-00004
 
It's probably completely nontoxic. I think it's the only common gabaminergic that doesn't cause memory impairment in modest doses.
It is i think sadly, what i been reading on NCBI indicating,
what i did. Coma inducing GHB sleep, a good neurotoxic sleep.

What is weird that Narcoleptic s do this 14 x a week.
So there is some missing info, like a PET scan s of the brain s,
of Narcoleptic s. But a change in ratio white/ black matter was observed.
Very strange they state only when using real high coma doses by recreative user s.
Narcoleptic s take higher doses then i did, only difference my weekend s.

In animal test or maybe human i ll look em up .

https://pmc.ncbi.nlm.nih.gov/articles/PMC7142256/ from 2020

Is GHB coma something diferent as GHB induced sleep ?
Narcoleptic s in general take 2 x 2.25 gram a night.

Glad we have Bluelight, Tripsitter and Psychonaut Wiki in this case.

While a common recreational dose is between 1.5 - 2.5 grams, a dose between 2.5 grams and 5 grams will likely result in falling asleep within 5 - 15 minutes, and a dose of 5 - 10 grams can result in convulsions, unconsciousness (a coma-like state) and vomiting. Doses above 10 grams are associated with a risk of death

Not entirely correct, convulsion s can occur at 2.5 gram.
And is ime not a re-creative dose, probably 90 % will sleep on 2.5 gram.
5 grams i can t imagine that is a double dose for inducing sleep.
Easy.
 
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Gymnastics on a tight rope between 2 flat s, why not?
I do it. But after 3 times Physical dependence, WD s last 3 weeks.
Compared with GHB, 3 day s. Torture, and Diazepam does shit.
Sadly addiction dr s know shit. I bet even GHB would be a better choice.

Hope i learned my lesson. But i did it by going 24/7.
The hard way, busy in making that never happens.
The most ineffective method was medical internal DETOX.

Rate of relapse 90 %. And so cheap-ass. Handing Mg-H-O.
A laxative as MG supplement, idiot s.

So forget medical help, but that is hopefully depended on location.
Don't forget psychiatrists! One of them claimed I had "complicated" alcohol withdrawal on the paperwork confirming my involuntary hospital admission. You know how I know she was full of shit? Because around that same time at home I had been pouring whisky and beer down my throat and I still had massive tremors, insomnia, anxiety, etc. I tried explaining that those symptoms were the result of being abruply cut off from multiple medications including haloperidol. That was totally ignored and one doctor even denied that haloperidol causes withdrawal. Maybe there's a new kind of alcohol WD that doesn't go away after 15 beers.
 
Don't forget psychiatrists! One of them claimed I had "complicated" alcohol withdrawal on the paperwork confirming my involuntary hospital admission. You know how I know she was full of shit? Because around that same time at home I had been pouring whisky and beer down my throat and I still had massive tremors, insomnia, anxiety, etc. I tried explaining that those symptoms were the result of being abruply cut off from multiple medications including haloperidol. That was totally ignored and one doctor even denied that haloperidol causes withdrawal. Maybe there's a new kind of alcohol WD that doesn't go away after 15 beers.
We don t have those here, :rolleyes:, but those that are tied to a Mental health Business.
By default suck, like lie cheat deceit while knowing less then me.

But i met private Psychiatrist s, had to in order to get dextro-Amphetamine.
Instead of Methylphenidate, these 3 well i got my prescription.
But helping with lets say marriage problem s, no. So they where means to.

Get a med that didn t make my Heart-rate rocket, make me sweat/ tremble.
And losing weight, and enduring the irritating Pharmakinetic s.
The rebound, how could i forget, even Coke has no rebound effect.

And i hate Coke.
 
We don t have those here, :rolleyes:, but those that are tied to a Mental health Business.
By default suck, like lie cheat deceit while knowing less then me.

But i met private Psychiatrist s, had to in order to get dextro-Amphetamine.
Instead of Methylphenidate, these 3 well i got my prescription.
But helping with lets say marriage problem s, no. So they where means to.

Get a med that didn t make my Heart-rate rocket, make me sweat/ tremble.
And losing weight, and enduring the irritating Pharmakinetic s.
The rebound, how could i forget, even Coke has no rebound effect.

And i hate Coke.
I haven't used coke since new years eve 2018. Did 3.5g and then fell into extreme depression which took 2-3 days to feel normal again. I will never buy it again as long as amphetamines are available. Mixed salts, d-amp, d-meth, or even that European amp sulfate which pops up on Canadian market in limited amounts. And it's always nice to have a little stash of pregabalin or clonidine or both as PRN for that heart rate and tremble. Both can cause rebound anxiety so it's best to use 2-3 days a week max.
 
I haven't used coke since new years eve 2018. Did 3.5g and then fell into extreme depression which took 2-3 days to feel normal again. I will never buy it again as long as amphetamines are available. Mixed salts, d-amp, d-meth, or even that European amp sulfate which pops up on Canadian market in limited amounts. And it's always nice to have a little stash of pregabalin or clonidine or both as PRN for that heart rate and tremble. Both can cause rebound anxiety so it's best to use 2-3 days a week max.
Even dl-Amphetamine no way, all the PNS distraction, side effect euphoria.
Meth-Amphetamine has in NL since 70-ties officially lost its status has medical use.
Maybe Desoxyn has, but that will never enter our med market here never.

But dextro-Amphetamine oral, taking less then prescribed works all-right.
Or best, with a little THC/ CBD here and there.

My BP on dex i s so low i should faint, so its totally ok for me tom take.
Clonidine, and all other -idines no go for me.
I got BP 90 over 60 when active on a stim. HR 100 i biked to the dr.
A oddity, but not scary for my doccy that is worrying.

Alway s wonder dextro-Amphetamine is in general not available to most.
In NL, only one producer/ Pharmacist, and 1 insurance of the 100-ends.
That Cover s it, [basically it is free]

The insurance Company s even stopped methyl-Amine being payed for,
too Pharmacist s. why there only one left. As he makes his own.

But all kids 8 year old on that kiddie Coke, Methylphenidate.
Imo 4 th treatment option at best.

Lis-dex - dex-Amp - d-Methylphenidate XR ............ and if that don t work.
 
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