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how does 'G' work?

yeeya

Bluelighter
Joined
Sep 15, 2001
Messages
58
Location
Auckland nz
We all know exactly how 'E" works but how EXACTLY does 'G' work? What processess happen , what does it do to the brain ie what neourotransmitters are involved, the erowid and the like do not really explain this.
R E S P E C
 
Its my understanding that GHB restricts the realease on dopamine. Hence the CNS depressant effects. At the same time it increases production of dopamine, so that when it wears off, you get that "speedy rush" some may be familier with.
Chem
 
it probably does what you guys just mentioned but the main effect...definately dont quote me...is that it converts into some type of alcohol in your system. Thats why its soooOOo damn bad to drink alcohol with it. Its the reason why so many ppl OD on it. Their whole body just gets more and more depressed from alcohol until your brain stops controlling even simple functions like heart and breathing.... :(
thats as far as my simple knowledge on the drug goes... don't care to read about it on erowid because i don't care to _ever_ take the drug. no ghb no problems.... :)
After seeing the poor guy OD and need his heart pumped and pure oxygen suplied at 2Tribes cause of the stuff i never wanna try it....
id much rather live than get just another good HIGH... so should everyone?
be safe...
Rob.
 
Umm it does't produce a type of alcohol, from memory the reason you shouldn't have alcohol and g at same time is because your liver uses the same enzyme to break them both down. Which means higher concentrations get through.
Can't remember exact details but its something along those lines.
 
As mentioned above correctly in the first response to this post, GHB works on the dopamine release mechanism.
And the reason it is dangerous in comination with alcohol is becasue they are both depressants.
Same way in which heroin statistics suggest 85% of all heroin overdoses involved interaction with alcohol or other depressants.
 
Umm it does't produce a type of alcohol, from memory the reason you shouldn't have alcohol and g at same time is because your liver uses the same enzyme to break them both down. Which means higher concentrations get through.
It doesn't produce an alcohol.. That is correct, it breaks down into carbon dioxide and water from memory.. (or something benine like that)
Mixing with grog is bad because, as stated, there both depressents...
Now mixing 14B with alcohol is bad, because the alcohol will have to be broken down first before any of the 14B will be converted and then "G effects" will be felt.
ROBE said:
"After seeing the poor guy OD and need his heart pumped and pure oxygen suplied at 2Tribes cause of the stuff i never wanna try it.... "
Well, its not the drugs fault.. Its the stupid users fault...
Sorry.
Chem
 
Good ol 2D6 P40 (? i was gonna look it up but am hungry)is there anything it doesn't break down!
To answer the thread take BTs advice and visit erowid.
[Edit: I think CYP, 2D6, and P450 are the magic numbers you were groping for. BigTrancer]
[ 25 March 2002: Message edited by: BigTrancer ]
 
Thanks for your advice people. After checking out the section 6 thread bt suggested it appears that once you ascertain the correct dosage of ghb to give the desired effects there are virtually no ill effects/toxicity. In fact there are almost all benifits to be had especially in to the gym scene. I think I'll keep on truckin with 'G' in the passenger seat.
R E S P E C
 
POINT TO NOTE!!!!!
There are no ill effects to note with the use of REAL GHB (Gamma Hydroxy Butate)... NONE OF WHICH CAN BE FOUND IN MELBOURNE..
ALL the so called "G" in melbourne, is its filthy associate, 14B .. Which does have some serious implications with your little friend, your LIVER AND KINDEY, not to mention what it does to you when still in it 14B or GBL stage before converting to real G.
 
Hey Chemical night, any advice on how to tell what exactly it is that I'm getting? Is there a test similar to eztest for pills? I got it from a person who has done it for a long time but is not that well informed. I can only presume that what I am getting is the real deal unless you can give me some hints as to which is which.
R E S P E C
 
Um, well i can 100% say that if you live in melbourne, your not getting the real deal. Your geting 14b..
Easy way to tell.
14B tastes like chemicals, kinda like liquid plastic or something (very rank)..
Real ghb is a sodium salt.. IE IT tastes like salty water.. pretty much like your drinking someones sweat.
They are two VERY different tastes..
I can guarantee yours is 14b. (or GBL) most likely 14.
 
Yeah it tastes damn disgusting, also has strong smell. almost like anaceed, must be 14b, so what are the differece on the effects as far as toxicity and in our little friend? Also why the hell is there just this stuff around why not ghb, are 14b and gbl much easier to make or something.
R E S P E C
 
14B AFAIK, is still legal, hence easier to get. GHB has to be made from GBL and NAOH (caustic soda). From what i remember, the last people in melb who were "Making" GHB got busted... Well, so the story goes anyway.
Ill effects from 14B use.. Well, can't you tell? Most times if i have any amount (ie more than one dose) I end up with abdominal pains (ie liver /kidney pains). Your liver has to work very had to break down the 14B into GBL, and then finally the GBL into GHB.. This is a big body load..
Mind you this doesn't even take into account the effect the actual 14B and GBL have on the rest of your body/brain, as they prob have there own effects on the system (hence why 14B "feels" different to GHB.)
There has not been much research done into 14B use (as it is CD CLEANER, and was not made for human consumption - Unlike GHB which was legally sold as a health suppliment until 95ish)
Im sure its not good for you though.
Chem
 
chem> it never was or never will be CD cleaner... it was just labled as such to make it look kosher.
in concentrated form, it actually takes off paint :(
M
[ 28 March 2002: Message edited by: Maxi ]
 
hey chemical night, i used to get the same thing occasionally when I used 1,4. I find that milk thistle of any kind of healthfood store liver/kidney clensing product helps a lot. Also does the job for hangovers too :D
 
from my brief reading today (refer to the topic 1,4b info) im under the impression that its not that bad for you IF its cleaned properly.
as entrope pointed out in the main form it comes in (cd cleaner, industrial solvent or whatever) it contains heavy metals and dangerous chemicals. this may be the reason some people have bad experiences with it. i read charcol filtering is supposed to fix that. i haven't tried it however.
if you browse through the links in that topic theres peoples experiences using it for years and having no problems. also here is a report on the toxicity of consuming 1,4b
http://ntp-server.niehs.nih.gov/htdocs/ST-studies/TOX054.html
i quote:
"The lactone of g-hydroxybutyric acid, g-butyrolactone, is also rapidly converted to g-hydroxybutyric acid by enzymes in the blood and liver of animals and humans. g-Butyrolactone was previously evaluated by the NTP in 14-day and 13-week toxicology studies and 2-year toxicology and carcinogenesis studies in F344/N rats and B6C3F1 mice. No organ-specific toxicity occurred in the toxicology studies. In the carcinogenesis studies, an equivocal response occurred in male mice, based on a marginal increase in the incidence of pheochromocytomas of the renal medulla. Because of the rapid and extensive conversion of g-butyrolactone to g-hydroxybutyric acid, the evaluation of g-butyrolactone was in fact an evaluation of g-hydroxybutyric acid.
This summary report presents a review of the current literature which documents that both 1,4-butanediol and g-butyrolactone are rapidly metabolized to g-hydroxybutyric acid, and the pharmacologic and toxicologic responses to these chemicals are due to their metabolic conversion to g-hydroxybutyric acid. Because the toxicity and carcinogenicity of g-hydroxybutyric acid was fully evaluated in the NTP studies of g-butyrolactone, and a lack of organ-specific toxicity or carcinogenic potential was demonstrated, it is concluded that there is a high likelihood that 1,4-butanediol would be negative in a similar set of studies. For these reasons, it is the opinion of the NTP that 1,4-butanediol should be considered not carcinogenic in animals and no further evaluation of 1,4-butanediol is needed at this time."
[ 01 April 2002: Message edited by: surrealthoughts ]
 
Well that quote you took was talking about GBL, not 14B.
I have read many reports by regular users such as this
I started using 1,4-Butanediol as a health supplement, hoping to mimic the growth hormone releasing effects of GHB. I used at least 3 grams daily (solution has 9 grams per ounce of liquid) for a period of 6 months with occasional binges on weekends. I found the effects comparable to alcohol intoxication and would indulge in it instead of drinking. I was always very safe and responsible with my doses. I noticed no side effects at all from my use (other than some small stomach pain after binges) until I recently stopped (I ran out and hadn't ordered more. This did not concern me, as I don't consider myself addicted). A few days after stopping I noticed a strange coldness in my feet and fingers, despite 100+ degree temperatures outside. I would also become dizzy often when I stood up. The most worrisome side effect was a nagging pain in the left side of my chest. The pain came and went, accompanied by a racing pulse, often getting so bad I considered going to the emergency room. After about 2 weeks the side effects stopped and I've been completely normal since. I have more now, but have decided not to continue with its usage do to these effects.
and this
Began experimeting with daily dosing(~2.0-5.0g/day) of 1,4-Butanediol (99.9%). After nearly three weeks, I began to experience symptoms of possible 1,4-B toxicity. Upper respiratory congestion/irritation, ocular irration, and pain in upper right quadrant of abdomen. Possible systemic and organ specific toxicity? Getting LFT'S and general blood drawn. I'll report my results and experiences.
As promised, here are the results of my lab report. I have an isolated, elevated, bilirubin level. Actually quite high, 2.9(!). This could be and probably is indicative of some liver disfunction. Jaundice is usually apparent at 2.0 with yellowing of the conjunctiva (which I do have). All other LFT's appear normal. However, GGT was not evaluated.(This enzyme is very important as it is one of the only 'liver specific' ones). Getting more tests. Bilirubin (direct,indirect), Iron and GGT. I must admit, I've experienced some hepatic dysfunction in the past. Although my doctor believed it to be transite and not significant. I was a very heavy anabolic/androgenic steriod(AAS)user for more than eight years. I had very heavy use of oral(C-17) AAS, which can be significantly hepatotoxic. Unfortunately, I was also a binge drinker. Heavily abusing alcohol every weekend for over a year and a half. This undoubtly put undue stress on my liver perhaps causing some (subclinical) damage.
I believe it is entirely possible that I am very sensitive to many compounds with even mild hepatotoxic potential compared to the average person. So, my experiences with 1,4-B may not be applicable to those with out any prexisting conditions. I will report upon my condition and it's possible/causual link to 1,4-B ingestion in the near future.
Also, please have a read of this...
http://leda.lycaeum.org/Documents/1,4-Butanediol_Toxicity.15209.shtml
Chem
 
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