surrealthoughts
Bluelighter
- Joined
- Jan 19, 2001
- Messages
- 96
to respond to CN first comment ill post the paragraph that comes before those other two above ...
"As documented in the scientific literature, 1,4-butanediol is rapidly absorbed and metabolized to g-hydroxybutyric acid in animals and humans. A metabolism and disposition study conducted in F344/N rats by the NTP confirmed the rapid and extensive conversion of 1-[14C]-1,4-butanediol to 2. Because of this rapid and extensive conversion, the toxicological profile of 1,4-butanediol reflects that of g-hydroxybutyric acid. g-Hydroxybutyric acid is a naturally occurring chemical found in the brain and peripheral tissues which is converted to succinate and processed through the tricarboxylic acid cycle. Although the function of g-hydroxybutyric acid in peripheral tissues is unknown, in the brain and neuronal tissue it is thought to function as a neuromodulator. g-Hydroxybutyric acid readily crosses the blood-brain barrier, and oral, intraperitoneal, or intravenous administration elicits characteristic neuropharmacologic responses. These same responses are observed after administration of 1,4-butanediol."
as to CN first quote. it is well know ghb and its analogs can cause quite severe "withdrawal" symptoms. for MANY reports on withdrawal from GHB head to: http://www.erowid.org/experiences/subs/exp_GHB.shtml#Addiction_&_Habituation . for MANY reports on withdrawal from 1,4b head to: http://www.erowid.org/experiences/subs/exp_1,4-Butanediol.shtml#Addiction_&_Habituation .
also here is an article explaining why i used the word withdrawal loosely http://www.erowid.org/experiences/exp.php3?ID=169
on CN second quote i put forward the suggestion that the 1,4b that person was using was not cleaned properly and contained heavy metals and dangerous chemicals, as entrope commented in my post: http://www.bluelight.ru/cgi/ultimatebb.cgi?ubb=get_topic&f=35&t=001932 . same goes for Murples experience report which is commonly quoted as a source of toxicity. read my post on why i think it should be taken with a grain of salt.
for a page with a number of experiences of using 1,4b (most probably well cleaned and safe for human consumption) head to http://www.nutritionalsupplements.com/borametz.html . there are stories of people using 1,4b for YEARS with mainly positive stories. i suggest you read ALL the stories to get the full picture.
"As documented in the scientific literature, 1,4-butanediol is rapidly absorbed and metabolized to g-hydroxybutyric acid in animals and humans. A metabolism and disposition study conducted in F344/N rats by the NTP confirmed the rapid and extensive conversion of 1-[14C]-1,4-butanediol to 2. Because of this rapid and extensive conversion, the toxicological profile of 1,4-butanediol reflects that of g-hydroxybutyric acid. g-Hydroxybutyric acid is a naturally occurring chemical found in the brain and peripheral tissues which is converted to succinate and processed through the tricarboxylic acid cycle. Although the function of g-hydroxybutyric acid in peripheral tissues is unknown, in the brain and neuronal tissue it is thought to function as a neuromodulator. g-Hydroxybutyric acid readily crosses the blood-brain barrier, and oral, intraperitoneal, or intravenous administration elicits characteristic neuropharmacologic responses. These same responses are observed after administration of 1,4-butanediol."
as to CN first quote. it is well know ghb and its analogs can cause quite severe "withdrawal" symptoms. for MANY reports on withdrawal from GHB head to: http://www.erowid.org/experiences/subs/exp_GHB.shtml#Addiction_&_Habituation . for MANY reports on withdrawal from 1,4b head to: http://www.erowid.org/experiences/subs/exp_1,4-Butanediol.shtml#Addiction_&_Habituation .
also here is an article explaining why i used the word withdrawal loosely http://www.erowid.org/experiences/exp.php3?ID=169
on CN second quote i put forward the suggestion that the 1,4b that person was using was not cleaned properly and contained heavy metals and dangerous chemicals, as entrope commented in my post: http://www.bluelight.ru/cgi/ultimatebb.cgi?ubb=get_topic&f=35&t=001932 . same goes for Murples experience report which is commonly quoted as a source of toxicity. read my post on why i think it should be taken with a grain of salt.
for a page with a number of experiences of using 1,4b (most probably well cleaned and safe for human consumption) head to http://www.nutritionalsupplements.com/borametz.html . there are stories of people using 1,4b for YEARS with mainly positive stories. i suggest you read ALL the stories to get the full picture.
Generally around these parts there has been a bit of pro-GHB, anti-1,4b sentiment, which is fair enough I suppose given the historical angle we've arrived here from. It's kind of a moot point though IMHO because everyone bleats about how good GHB is and then drinks 1,4b all day because GHB isn't available. 
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