the_integerian
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Besides the duration, how do the effects of methylphenidate, amphetamine, and methamphetamine compare and contrast? Do they feel basically the same?
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OD Moderators: Keif’ Richards | Tryptamino
Stimulants How do the effects of methylphenidate, amphetamine, and methamphetamine compare?
- Thread starter the_integerian
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sekio
Bluelight Crew
Methylphenidate is a dopamine/norepinephrine reuptake inhibitor.
Amphetamine is a dopamine/norepinephrine releasing agent.
Methamphetamine is a dopamine/norepinephrine/serotonin releasing agent that metabolizes into amphetamine.
What this means for the layman -
Methylphenidate is 'similar' to pharmaceutical cocaine - some people prefer it to amphetamine and get clean stimulation but many find it feels "tweaky", has a horrible 'crash' or makes them paranoid and jittery, especially in high doses.
Amphetamine is similar to a longer-lasting methylphenidate that is more "intense" in general. It generally causes a good degree of perhipheral side effects like sweating, vasoconstriction and flushing. It's also a lot more fat soluble so it has a slower "comedown" than methylphenidate. Overuse can lead to hangovers and tolerance, much faster than with methylphenidate.
Methamphetamine is like a very long lasting, "smoother", more euphoric (generally) and stronger version of amphetamine. The major difference is that the total half life for the stimulant is almost 24 hours (6-12 hours for meth->amp, 12 hours for amp->inactive). It's also considered neurotoxic whereas the other two are not.
Amphetamine is a dopamine/norepinephrine releasing agent.
Methamphetamine is a dopamine/norepinephrine/serotonin releasing agent that metabolizes into amphetamine.
What this means for the layman -
Methylphenidate is 'similar' to pharmaceutical cocaine - some people prefer it to amphetamine and get clean stimulation but many find it feels "tweaky", has a horrible 'crash' or makes them paranoid and jittery, especially in high doses.
Amphetamine is similar to a longer-lasting methylphenidate that is more "intense" in general. It generally causes a good degree of perhipheral side effects like sweating, vasoconstriction and flushing. It's also a lot more fat soluble so it has a slower "comedown" than methylphenidate. Overuse can lead to hangovers and tolerance, much faster than with methylphenidate.
Methamphetamine is like a very long lasting, "smoother", more euphoric (generally) and stronger version of amphetamine. The major difference is that the total half life for the stimulant is almost 24 hours (6-12 hours for meth->amp, 12 hours for amp->inactive). It's also considered neurotoxic whereas the other two are not.
the_integerian
Bluelighter
- Joined
- Apr 15, 2010
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Thank you!
opiatekrzy
Bluelighter
yeah ritalin and cocaine BLOCK reuptake of dopamine; they both work on the brain the same exact manner. the only difference is cocaine reaches the Blood Brain Barrier much much faster. Amphetamines release dopamine/serotonin..
Captain.Heroin
Bluelight Crew
Methamphetamine feels a lot more euphoric than d-amphetamine, and in my experience, the D isomer of meth as well as regular amphetamine are very preferrable over "mixed salts" formulas.
With d-amphetamine, I would only reccomend the oral ROA. The other ROA's aren't as effective IMO. With d-methamp in crystalline form, I find this can be used with other ROA's successfully.
With d-amphetamine, I would only reccomend the oral ROA. The other ROA's aren't as effective IMO. With d-methamp in crystalline form, I find this can be used with other ROA's successfully.