DiRtYjErZ
Bluelighter
I ask this because I kno lunesta is just the isomer of it. But looking at each drugs related wiki article the zopiclone article goes way in depth how zoplicone is active at the gaba A receptors n the 1345 sites I guess? I'm under the influence so memories a lil hazed lol.
From wiki on zopiclone (Under pharmAcology section)
The therapeutic pharmacological properties of zopiclone include hypnotic, anxiolytic, anticonvulsant and myorelaxant properties.[62] Both zopiclone and benzodiazepines act indiscriminately at the benzodiazepine binding site on α1, α2, α3 and α5 GABAA containing receptors as full agonists causing an enhancement of the actions of GABA to produce the therapeutic and adverse effects of zopiclone.
To save you the trouble and hopefully to answer my ?'s here is wiki on lunesta::
Eszopiclone acts on benzodiazepine binding site situated on GABA-A neurons as an agonist.[6] Eszopiclone is rapidly absorbed after oral administration, with serum levels peaking between 1 and 1.3 hours.[7] The elimination half-life of eszopiclone is approximately 6 hours and it is extensively metabolized by oxidation and demethylation. Approximately 52% to 59% of a dose is weakly bound to plasma protein. Cytochrome P450 (CYP) isozymes CYP3A4 and CYP2E1 are involved in the biotransformation of eszopiclone; thus, drugs that induce or inhibit these CYP isozymes may affect the metabolism of eszopiclone. Less than 10% of the orally administered dose is excreted in the urine as racemic zopiclone.[8] In terms of benzodiazepine receptor binding and relevant potency, 3mg of eszopiclone is equivalent to 10mg of diazepam.[ <---------under pharmacology section.
This leads me to believe there has to be alot more to my lunesta then the usual that craps beat ya kno? Any discussion on this? Thanks guys. I'll provide the sourcelinks at bottom. Tho it is wiki. The worst source. Which is y I came here lol.
Lunestawiki ---------> http://en.m.wikipedia.org/wiki?search=Lunesta
Zopiclone ------------> http://en.m.wikipedia.org/wiki?search=Zopiclone
Ps I meant stereoisomer not isomer of zopiclone
From wiki on zopiclone (Under pharmAcology section)
The therapeutic pharmacological properties of zopiclone include hypnotic, anxiolytic, anticonvulsant and myorelaxant properties.[62] Both zopiclone and benzodiazepines act indiscriminately at the benzodiazepine binding site on α1, α2, α3 and α5 GABAA containing receptors as full agonists causing an enhancement of the actions of GABA to produce the therapeutic and adverse effects of zopiclone.
To save you the trouble and hopefully to answer my ?'s here is wiki on lunesta::
Eszopiclone acts on benzodiazepine binding site situated on GABA-A neurons as an agonist.[6] Eszopiclone is rapidly absorbed after oral administration, with serum levels peaking between 1 and 1.3 hours.[7] The elimination half-life of eszopiclone is approximately 6 hours and it is extensively metabolized by oxidation and demethylation. Approximately 52% to 59% of a dose is weakly bound to plasma protein. Cytochrome P450 (CYP) isozymes CYP3A4 and CYP2E1 are involved in the biotransformation of eszopiclone; thus, drugs that induce or inhibit these CYP isozymes may affect the metabolism of eszopiclone. Less than 10% of the orally administered dose is excreted in the urine as racemic zopiclone.[8] In terms of benzodiazepine receptor binding and relevant potency, 3mg of eszopiclone is equivalent to 10mg of diazepam.[ <---------under pharmacology section.
This leads me to believe there has to be alot more to my lunesta then the usual that craps beat ya kno? Any discussion on this? Thanks guys. I'll provide the sourcelinks at bottom. Tho it is wiki. The worst source. Which is y I came here lol.
Lunestawiki ---------> http://en.m.wikipedia.org/wiki?search=Lunesta
Zopiclone ------------> http://en.m.wikipedia.org/wiki?search=Zopiclone
Ps I meant stereoisomer not isomer of zopiclone
