Opioids How did oxycontin remove my nerve pain completely?

[Juniper Bruhmomentius]

So Ive suffered some shit ass nerve damage from OD and took oxycontin to feel better. I didnt expect the nerve damage to go away, but it completely did while the oxy was in my system.
How the fuck is this possible?

 

[Jabberwocky]

this thread may get closed because it sounds like a speculation thing plus it sounds like" why did this pain killer kill my pain?"

isn't this the whole purpose of opioids? or are you referencing the fact that it worked on nerve pain specifically?

 

[Juniper Bruhmomentius]

Yeah the fact that it cured the nerve pain which I had no idea would happen. Im propably wrong, but I thought nerve pain would need special nerve pain meds? Tho gabapentin did nothing for my nerve pain...

 

[Jabberwocky]

oh I see now what you mean, sorry for the misunderstanding ! in my knowledge lyrica is prescribed for things like that

 

[Juniper Bruhmomentius]

No problem man. I have severely abused lyrica in the past so I wont be getting any and actually dont even want to. I dont really care about the pain during daytime, but I tend to sleep in 1-3 hour periods, which results in feeling like Im fucking abusing antipsychotics or some shit.

Actually, I assume that because I got history with scripted lyrica gabapentin doesnt do shit.

 

[Shortec Stublue!!]

All Nerve endings are still ran back to be assessed in the brain. So opioid receptor activation comes from all aspects of pain. Specific neuropathic pain meds like the ones you mentioned, modify or block things like calcium channels etc!!

 

[negrogesic]

Opioids can work pretty well for peripheral neuropathic pain but not so great in other forms (like neuropathic pain stemming from a spinal chord injury).

 

[Juniper Bruhmomentius]

Thanks for the inputs! I guess this is the kind of neuropathic pain that needs opiates.

 

[Mini Chef]

Thanks for the inputs! I guess this is the kind of neuropathic pain that needs opiates.

Try telling that to my doctors.

Almost thought you were me for a second. Will see if it works for me!

 

[Shortec Stublue!!]

It’s all a matter of signalling, pain is not really pain (stupid I know) it is perception. Just like if your brain decides that the green apple you see is blue, then it signals that. So nerve pain muscular, bone, acute or chronic pain is being signalled one way or another. Find the channel you need and stick with it ??

 

[Nicomorphinist]

I wonder if the efficacy of oxycodone against neuropathic pain has to do with the stimulating effect we have been discussing. Two strategies for combatting nerve pain are to combine a narcotic with an anticholinergic and/or a stimulant. There are other reasons too, like somnolence and orthostatic hypotension for combining stimulants with narcotics, but they also potentiate them. Merck made a combination of oxycodone, hyoscine (scopolamine), and ephedrine called Scophedal from 1928 to 1987 and compounders can still make it, and when I take it for breakthrough pain, I feel not like Jesus' son but the Boss God Himself. It was specifically designed to produce "Very deep analgesia and profoundly intense euphoria whilst maintaining vital signs within 20 per cent of baseline" during surgery, sedation, battlefield injuries, severe pain, and so on.

 

[Shortec Stublue!!]

Love it Nico, but a Heroin/thebaine selection box was on my Great Grandads kitchen table, as a young man, for a choice of teatime snuff, smoke or a rub on the gums. So maybe not all combos should stand the rest of time lol.

I think an Oxy dosage of your choice and a Pregabalin, should (supposedly) cover all bases. This is also a combo I only found out recently!!