Hot-7 + hpbcd?

[Doses]

Would it work just like any of the NBOMEs with HPBCD?

UPDATE:

A friend of mine was recently arrested with a vial of HOT-7 complexed with HPBCD in his possession. Authorities could not make heads or tails of what it was, so initially they attempted a charge of Meth/Ecstasy. Realizing their stupidity (in my opinion; albeit, they actually tried testing it for either and it came up negative), they made an attempt to charge him with LSD. Results, again, returned negative. Upon questioning what was in the vial, he told them HOT-7. LE has no idea what HOT-7 is. Under analysis, all that returned was d20 and sugar.

In court papers, it's confirmed that a substance they did test for was 2c-t-7, and results returned negative. They were really determined to nail him on something, and couldn't. There wasn't even an impurity of 2c-t-7 (because if there was so much as 1%, they would have tacked him for it. I'm aware of such a case in which 4-FA was found with a 1% impurity of amphetamine, and a man was sentenced 7+ years for sales of amphetamine with a 99% "impurity" of 4-FA).

Conclusion: HPBCD must somewhat protect the HO end of HOT-7. The vial has been sitting in a safe in the back of a car for 2 months now without degrading. Maybe this molecule is a tad bit more stable than you all supposed.

 

[Vaya]

Homeless >>> Psychedelic Drug Discussion

 

[sekio]

Maybe. Ususally the plain non-benzylated PEA's have a good BA by nasal/rectal/sublingual without "complexing".

 

[Solipsis]

^ Never take thio PEAs like this nasally.

Complexing might be an idea especially if the HPBCD dissociates from it relatively late, protecting the hydroxylamine group so that you actually could get more HOT-7 effects than just 2C-T-7 effects. We probably don't even know if there is any pharmacodynamic difference between the two and if it is only the kinetics that make a difference (cf. 4-AcO vs 4-HO tryptamines), even if that difference can still be subjectively quite significant.

I'm not optimistic about the HOT-7 I have sitting, even if it is deepfrozen.

But I wouldn't use HPBCD on HOT-7 just to increase bioavailability, otherwise you could try it with virtually anything - then where does it end?

 

[Doses]

Awesome, so it would basically protect it from degrading?

If I may ask, what would the best method of complexing it be? Would I follow a procedure similar to complexing NBOMes?

 

[sekio]

no, thats just a hypothesis, it would likely do absolutely nothing of note aside from be placebo IMO as most of the 2c's are well absorbed. The whole reason people complex NBOMes is because they are thought to be *not* well absorbed unless you complex them or add something like Tween.

all HPBCD complexing does it make certain less-water-soluble heavy molecules (testosterone, NBOMes, etc) dissolve better in water.

generally the pea's are stable for many many years on their own

 

[Solipsis]

Yes if you are happy with HOT-7 reverting to 2C-T-7 there is no problem at all, but the hydroxylamine is thought to be unstable/reactive so the generalization does not help.

Thanks indeed it was just a hypothesis if it may help with stability. If don't know if this reasoning holds up, but if the degradation comes from unfavorable reactions with gases in the air, and all HPBCD does is provide a sort of fish-trap for molecules, does the HPBCD not cover up a few angles, limiting the reactions?
Then again it seems that hydroxylamines may just be thermally unstable, then it won't help at all. I admit it is a weak idea, but maybe worth a shot.

Sekio, it's not that these compounds are heavy (is it?), but that they have problematic solubility. If there were polar substitutions all over it, I doubt it would be an issue.

 

[Doses]

So, say I went ahead and was going to complex it, just to do it because why not.

Could HPBCD possibly reduce the sting associated with insufflating, or the foul taste? How late does HPBCD dissociate after administration?

 

[Doses]

Update: I went ahead and did it.

Call it placebo, but 11.5mg complexed and laid on a piece of gum was MUCH more vivid than 15mg up the nose; not to mention, no foul taste. Onset was about the same too, so no complaints over in this department.

I think it was worth it. Also considering if you complex it in d20, you don't need too much HPBCD, unlike NBOMes with the 9:1 ratio since there's no ethanol competing for guest host. Use a 6:1 ratio and you should be more than chillen, in fact that's still slightly abundant.

Again, I'm well aware that HOT-7 HCl is hydrophilic. This is more for the purpose of removing the pain from insufflation, while possibly protecting the molecule from degrading and... Oh, and for science. That's why.

Kick rocks if you don't like my reasoning.

 

[Doses]

Update in OP.