how has low and high lsd doses positively/negatively affected your lives?
Both have positively affected my life, a few times profoundly, but it wasn't until I "broke though" on my first high dose that I felt I was really able to gain a lot more from the LSD experience (that trip was around 650-700ug). I generally have a hard head when it comes to psychedelics, but I know for a fact I've had extremely potent blotter before, often knowing the dosage that it was laid at, allowing me to quite precisely measure my doses.
On one trip of around 1400ug (plus ~.2 smoked DMT) I had an incredibly beautiful trip with my brother that has forever altered our relationship as siblings. We weren't especially close growing up, but had gotten closer after smoking together and a moderate mushroom trip, but this was an extreme bonding experience, pushing us both pretty far. The highlights included having a 15 minute conversation without saying a word, we were just so perfectly in tune we didn't have to speak.
I also dosed ~3300ug once, and it probably saved my life. I'd been really depressed and regular LSD trips had helped me improve my overall state of mind but this one trip just shattered my ego so completely I was able to be completely reborn as a less anxious more centered individual. It wasn't an easy experience but it was so worth it. It's not for everyone but I'd take high doses several times before that (the two mentioned plus probably 5 more 1mg+ experiences) and every time it had been extremely profound.
Even years later I consider my high dose trips some of the seminal experiences in my life, just because I've been able to learn so much about myself and grow as a person, in ways that would (and have) taken years of therapy to do naturally. It's not easy to integrate knowledge gained during tripping into your daily life but it is possible.
Edit: I do agree with the poster above me as well, I'm in no way burned out but acid seems to affect me more than it used to. Maybe it's because I've already opened the door so wide but my trips can much more easily descend into psychosis now (not paranoia, just psychosis-easily identifiable as such but stranger than they used to be). They've also gotten weirder and more reality-disturbing profound, which can be difficult to handle. Could also because when I took it more regularly I was comfortable with the environment too, which I'm less so now (more likely to trip at festivals, with people, etc.).