Cocaine High opiate tolerance interfering with Cocaine effects?

[Twiztidd]

My buddy has an extremely high opiate tolerance. Started with pain killers, and eventually graduated onto H, and then finally IV. He's at the point where he uses large amounts intravenously 3-5 times a day, and gets absolutely no effect from it other than relieving his withdrawals. Now onto the question...

He began using Cocaine occasionally a couple months back, and noticed that he seemed to get all of the amphetamine effects of it, IE: Alertness, Staying awake for hours, lots of energy, sometimes rapid heartbeat, anxiety, and feeling extremely racy, depending on how much and what the quality was. However, he has yet to get even the slightest bit of euphoria from it, no matter how much he takes or what the supposed quality was. Does this have to do with the fact that he can no longer get euphoria from H as well? I know cocaine reacts with your dopamine receptors, so did the H burn out his dopamine receptors to the point that it doesn't matter what the substance is, the receptors are just shot?

Then on the other hand, just the other day he was able to get some stuff from a different source, and he noticed immediately after doing the first 2 lines that he was hit with extreme euphoria which lasted about 20 minutes. I don't know what was different about this particular batch, but ever since that happened he has gone to this new source several times and never had the same results again. So what was so special about this one time from this one source?

I guess I'm just trying to determine if everything he's getting is just garbage, and that's why he feels nothing? And maybe this one batch was extremely good quality? Or if his dopamine receptors are shot from the H, and this particular batch was cut with something different this time like mdma or something?

Any insight would be appreciated

Thanks!

 

[Twiztidd]

Really? No one has any ideas?? I just watched my buddy Rob rail down 1g of blow in 2 minutes, and he's claiming he has absolutely zero euphoria, just wide awake and alert with a ton of energy, a tiny tiny bit racy, but not paranoid and racing heart. My other buddy Steve, who is here as well, did the exact same stuff, and after only 2 lines, he claimed he had a buzz going, 2 more lines and he says that with no doubt what so ever, he absolutely has a strong feeling euphoria in his whole body. Steve also agrees that the euphoria he is getting from this, is nowhere near as good as the stuff he got from the different source that gave Rob his very first and only euphoric experience from cocaine.

So what is the deal here people? I've searched far and wide to find out exactly what's going on here. Every thing I've found on the topic were short, non detailed answers, but most people seem to agree that tolerances don't cross over between Goodies. But based on the current situation that Steve is in, it seems to me that doing so much H, for as long as he's been, has destroyed his dopamine receptors, in which case it shouldn't matter what the substance is, if it's designed to release dopamine, It's not going to work because of what the H has already done to the receptors.

On the other hand then, I don't know how to explain the intense euphoria he experienced after just 2 lines of the stuff from the different source. To add even further to it, he had just done a shot of H maybe a half hour before doing these lines, and the H didn't even get him slightly high, just kept him from going into withdrawals. Keep in mind that this was an enormous shot as well. To give you an idea of the size, it was 5 times the amount that my other friend OD'd on. He's doing shots that are 5 times bigger than those on a daily basis, probably 4-6 times a day.

 

[Ksa]

Point is, you don't know if his receptors are shot and you don't know what's in the powder you get on the street, so bottom line is you know nothing and no one can say better.

 

[Twiztidd]

Point is, you don't know if his receptors are shot and you don't know what's in the powder you get on the street, so bottom line is you know nothing and no one can say better.

You're exactly right, I don't know those two things, but luckily for me, that isn't what I was asking. I'm simply asking if a high tolerance to opiates will effect the euphoria aspect of cocaine. I'm not asking if anybody knows if his receptors are shot, and I"m not asking what was in that particular batch. Most people are under the impression that there is no cross tolerance between the two, but given the situation I am looking at, it appears rather plausible, on top of that, using basic common sense, it seems pretty likely to me that a Dopamine receptor is a Dopamine receptor, and no matter what substance you use. If it effects your dopamine receptors, than any other drug that also stimulates those same receptors should have diminish results. But as I've previously stated, most people say that there is no cross tolerance....

Now... If I can get an actual real answer from somebody intelligent about the possibility of heroin and cocaine having cross tolerances, then I believe it will be rather easy to figure out the answers to the two questions that you posted in reply

 

[downerhead]

No,tolerance to heroin has nothing to do with tolerance to cain.I used to be a heavy-duty heroin addict for years and would only occasionally do cain.I could handle massive,yo-yo shots of dope with no problem.I'm talking shots that would most likely kill someone without a high tolerance,yet I remained very sensitive to cocaine.Sounds like your buddy was just getting shitty drugs.Hell,it might not have been cocaine at all but some kind of crushed up speed.Street drugs can be very iffy unless you have a good source.While it is true that both substances stimulate the pleasure centers of the brain their effects are completely different.If the kind of cross tolerance you are thinking of was the case,then an alcoholic would be immune to heroin,yet we know this is not true.I hope this provides the answer you seek.

 

[Twiztidd]

Yes thank you so much Downer! Your explanation was PERFECT. That is exactly the response I was looking for. Answered my questions and more