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hi... i need help!

i want to feel alive and not dead!!!
don't come to this forum if it is to complicated for you...
noradrenaline not always makes anxiety!!!! this is an important neurotransmitter that's why drugs companies makes drugs that working on noradrenaline!!! don't think you smart!!! you just like the stupid doctors just without the "doctor"
 
Yea I couldnt agree with Negrogesic more, on all the points he made.
If you truly are certain that you are deficient in NE, then Strattera would probably be the best medication to take since it specifically inhibits the reuptake of NE.
You may also want to try some of the tricyclic anti-depressants, since many of these will also increase NE levels, but are not so specific to NE (meaning you will also raise your serotonin levels).

I also agree with Negrogesic that increased NE levels will likely make you feel very on edge and jittery.

It would help if you could explain why you are so certain that you are deficient in NE. You only tell us that you are certain, but dont tell us why you are so certain, which is why so many people are suggesting you go to a doctor. People self-diagnose all the time, and are often completely wrong in their diagnosis. Perhaps you have reason to strongly believe you are deficient in NE, but until you tell us why you are certain, you must understand that people will be doubtful, and suggest you speak with a doctor.

By the way, do you have low blood pressure. For those who are NE deficient, you would expect them to have lower blood-pressure. However, this does NOT mean that low blood pressure equals low NE levels, it is just one indicator.

Getting back to things that you could take that might increase NE levels (assuming you actually do have low levels).
You could also consider Resperine. This will also increase NE levels, but through a different mechanism (it is a more complex mechanism then reuptake inhibition, and has to do with vesicular transport), but once again, this is something you would NEED to discuss with your doctor. There are also alpha blockers like phenoxybenzamine, which would also increase NE levels. I know you seem intent on treating this yourself, but even if you are 100% correct that you have low NE levels, you would still need to work with a doctor in order to safely and effectively, come up with a drug regimen to increase these levels.

If you want to try some things without the supervision of a doctor, that you can safely do, and might increase NE levels, I suggest the following.
Increase your protein intake (meat, eggs, etc). Protein is used by the body to make l-tyrosine, which is then eventually converted to NE (from dopamine).

You can also try to take l-tyrosine supplements. You mentioned you did this and it worked for 2 days (Im not sure how you can really know how long it increased your NE levels, other then how you "felt", which is HIGHLY subjective). So I would suggest taking l-tyrosine again, for at least a month, and see if you notice any difference.
And oddly enough, I just googled things which can increase NE, and believe it or not, banana PEELS contain high levels of both NE and dopamine (no guys, this isnt another "smoking banana peels" joke).

So, in summary, if you want to try to raise levels on your own, you can
1-eat more protein
2-take l-tyrosine for at least a month
3-.....I guess scrape the inside of a banana peel and eat it.

Other then that, there are many, many different meds that can raise NE levels. Some things (like Strattera) will selectively raise NE, other things will raise NE, but also raise serotonin and others in the process.
So, if you want to try these medication, talk to your doc about
1 Strattera
2 Resperine (alters vesicular transport)
3 Alpha blockers like phenoxybenzamine
4 Tricyclic antidepressants

That should be plenty to give you a good start. I would think Strattera would be the best med to try, as it is one of the few things that really targets NE, specifically. Hope this helps-DG


PS-Stop attacking people that are just trying to help. No one is trying to be a "smart ass". You might not even be aware, but officially, this site is categorized as a "harm reduction site". It would not be consistent with the idea of "harm reduction" if people were to suggest that you go off and consume a bunch of medications without consulting with a doctor. It seems that English is not your first language, so I will give you the benefit of the doubt and assume that you might be misunderstanding the tone and message of many of these posts, but you must understand, people are just trying to help and give you good, SAFE information.-DG

PPS-Also realize that when you attempt to change neurotransmitter levels, it very often takes quite some time until you notice any difference. With whatever supplement or med you choose, be certain to give it at LEAST a month before you decide it isnt working and dismiss it. None of these supplements/meds will work overnight, or even in a week. This isn't as simple as taking something for a headache. You are attempting to fine-tune neurotransmitters through complex mechanism. Expect it to take some time, and BE PATIENT.
 
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daddysgone said:
Yea I couldnt agree with Negrogesic more, on all the points he made.
If you truly are certain that you are deficient in NE, then Strattera would probably be the best medication to take since it specifically inhibits the reuptake of NE.
You may also want to try some of the tricyclic anti-depressants, since many of these will also increase NE levels, but are not so specific to NE (meaning you will also raise your serotonin levels).

I also agree with Negrogesic that increased NE levels will likely make you feel very on edge and jittery.

It would help if you could explain why you are so certain that you are deficient in NE. You only tell us that you are certain, but dont tell us why you are so certain, which is why so many people are suggesting you go to a doctor. People self-diagnose all the time, and are often completely wrong in their diagnosis. Perhaps you have reason to strongly believe you are deficient in NE, but until you tell us why you are certain, you must understand that people will be doubtful, and suggest you speak with a doctor.

By the way, do you have low blood pressure. For those who are NE deficient, you would expect them to have lower blood-pressure. However, this does NOT mean that low blood pressure equals low NE levels, it is just one indicator.

Getting back to things that you could take that might increase NE levels (assuming you actually do have low levels).
You could also consider Resperine. This will also increase NE levels, but through a different mechanism (it is a more complex mechanism then reuptake inhibition, and has to do with vesicular transport), but once again, this is something you would NEED to discuss with your doctor. There are also alpha blockers like phenoxybenzamine, which would also increase NE levels. I know you seem intent on treating this yourself, but even if you are 100% correct that you have low NE levels, you would still need to work with a doctor in order to safely and effectively, come up with a drug regimen to increase these levels.

If you want to try some things without the supervision of a doctor, that you can safely do, and might increase NE levels, I suggest the following.
Increase your protein intake (meat, eggs, etc). Protein is used by the body to make l-tyrosine, which is then eventually converted to NE (from dopamine).

You can also try to take l-tyrosine supplements. You mentioned you did this and it worked for 2 days (Im not sure how you can really know how long it increased your NE levels, other then how you "felt", which is HIGHLY subjective). So I would suggest taking l-tyrosine again, for at least a month, and see if you notice any difference.
And oddly enough, I just googled things which can increase NE, and believe it or not, banana PEELS contain high levels of both NE and dopamine (no guys, this isnt another "smoking banana peels" joke).

So, in summary, if you want to try to raise levels on your own, you can
1-eat more protein
2-take l-tyrosine for at least a month
3-.....I guess scrape the inside of a banana peel and eat it.

Other then that, there are many, many different meds that can raise NE levels. Some things (like Strattera) will selectively raise NE, other things will raise NE, but also raise serotonin and others in the process.
So, if you want to try these medication, talk to your doc about
1 Strattera
2 Resperine (alters vesicular transport)
3 Alpha blockers like phenoxybenzamine
4 Tricyclic antidepressants

That should be plenty to give you a good start. I would think Strattera would be the best med to try, as it is one of the few things that really targets NE, specifically. Hope this helps-DG
Click to expand...

i didn't read you all post because it is late here is 2:30 at night but i'll give you short explain and read tomorrow the rest.
first at all NRI like strattera don't make your brain produce more NE. it is just reuptake inhibitor but if you don't have enough NE than it wont work and worse - it will makes you a paradoxically influence.
i tried desipramine, edronax (pure NRI), and others... all of them makes me more tired' more depressed, and do to anything even when you large you dosage (i was on 300mg per day desipramine).
when i tried to take MAOI like nardil in high dosage and then with the nardil i tried desipramine - then suddenly the desipramine was working and makes me awake and with energy instead of the opposite. but there is a fatal interaction between this two meds and they makes me really bad side effects...but i understand that i have lack of NE.
now it is more clear?
i tried l-tyrosine for 35 days. helped me for 2 days only
 
A cocktail of L-Tyrosine and PEA caused instant hypertension for me. 175/110. not horribly dangerous of course but plain old amphetamine never came close to that in sane doses.
 
hi LUPUS
i tried l-tyrosine and it worked for just 2 days/.
what is PEA?
 
dl-phenylalanine

Be careful combining the two please. You would be better off with a traditional oral amphetamine or just sticking to caffeine.
 
hi
dl-phenylalanine is not the previous material of l-tyrosine?
if i tried l-tyrosine and it didn't helped me than dl-phenylalanine may help?
 
shir said:
i want to feel alive and not dead!!!
don't come to this forum if it is to complicated for you...
noradrenaline not always makes anxiety!!!! this is an important neurotransmitter that's why drugs companies makes drugs that working on noradrenaline!!! don't think you smart!!! you just like the stupid doctors just without the "doctor"
Click to expand...

Obviously its an oversimplification to say NE simply causes fear and nervousness, but the compounds that selectively release or inhibit its reuptake often cause these symptoms. Yes, the role is far more complex, and NE has beneficial and essential functions, but that is not really relevant here.

I don't believe I am dealing with a rational person here with a clear or even basic understanding of neuropharmacology so its useless to go far beyond a simplification. If you are not even bothering or capable of reading the full responses of others, why should we waste our time?

Again, what makes you think that your brain needs more NE? People have come to this forum in similar states saying "my brain needs more dopamine". Don't you think that is an oversimplification?

Go see a competent psychiatrist...
 
negrogesic said:
Again, what makes you think that your brain needs more NE? People have come to this forum in similar states saying "my brain needs more dopamine". Don't you think that is an oversimplification?
Click to expand...

I think he's actually one-upped the monoamine fixators. Like, way-upped.

If you get dizzy, lightheaded or faint after standing upright for a little while (if you can NEVER stand up straight for more than a minute or two) then see the links below. Otherwise, lack of norepinephrine production is not the problem.

Dopamine Beta Hydroxylase Deficiency

DBHD at OMIM

L-DOPS
 
seep said:
I think he's actually one-upped the monoamine fixators. Like, way-upped.

If you get dizzy, lightheaded or faint after standing upright for a little while (if you can NEVER stand up straight for more than a minute or two) then see the links below. Otherwise, lack of norepinephrine production is not the problem.

Dopamine Beta Hydroxylase Deficiency

DBHD at OMIM

L-DOPS
Click to expand...

from what i read in your links, there is no medication that increase the dopamine beta hydroxylase... the medications just increase the blood pressure but not treat the depression... am i right?
 
I think what hes saying is if you were truly NE deficient you would become very lightheaded when sitting upright. I suppose there could be exceptions, but with true NE deficiency, you would REALLY expect to see very low blood pressure.-DG
 
the true is that my blood pressure right now is pretty normal. but!! - 7 years ago when my depression was very less - i was trying to get a driving license and the dr. test me blood pressure and he found out that i had 187/120. no anxiety.. it was just a high blood pressure just like my father have a high blood pressure... i want to try the l-dops. i really didn't know that there is a med that help to push brain to make more noradrenaline from dopamine.
noradrenaline is not the only thing that have to do with blood pressure..
 
I am going to ask one final time for you to explain your reasons for why you are so certain that your symptoms (tired, lethargic, depressed etc.) are due to NE levels. You keep insisting that you KNOW that your symptoms are the direct result of low NE levels, but you really need to explain why you are so certain.

There are so many things that can cause the symptoms you describe, please explain why you attribute your symptoms to NE.
 
i already explaind
here is what i said:

first at all NRI like strattera don't make your brain produce more NE. it is just reuptake inhibitor but if you don't have enough NE than it wont work and worse - it will makes you a paradoxically influence.
i tried desipramine, edronax (pure NRI), and others... all of them makes me more tired' more depressed, and do to anything even when you large you dosage (i was on 300mg per day desipramine).
when i tried to take MAOI like nardil in high dosage and then with the nardil i tried desipramine - then suddenly the desipramine was working and makes me awake and with energy instead of the opposite. but there is a fatal interaction between this two meds and they makes me really bad side effects...but i understand that i have lack of NE.
MAOI increase the quantity of noradrenaline and thats what makes the desipramine suddenly work.
now it is more clear?
 
You do realize there's only so much noradrenaline the brain will manufacture as noradrenaline is an inhibitor of tyrosine hydroxylase, whuich is a step in the biosynthesis of noradrenaline? So no matter how much suppliment you take, there's only so much noradrenaline going to be made from it (unless you use L-DOPA, but that's an extremely bad idea as you'll also end up with a load of excess dopamine and will develop writhing movements like parkinson's patients who've received too much L-DOPA)
 
shir said:
if yu can't help then don't fucking replyig i don't need that kind of "advices"!!!!:X
smart ass
and don't be in that forums if you don't self medicate
Click to expand...

sort your bad attitude out- no-one on bluelight deserves abuse so dont produce it!

you have a really set idea of what your problem is and have turned it into some kind of overspecific chemical imbalance- why not explain in detail the symptoms

there are drugs out there that can increase the output of noradrenaline but they are not going to be effective for anything other than the short term (think NE releasers) .http://www.bluelight.ru/vb/showthread.php?t=407191

explain the problem better for a better response- we can only go on what you give us (and were not here to give bad advice either)
 
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MAOI increase the quantity of noradrenaline and thats what makes the desipramine suddenly work.
now it is more clear?
Click to expand...


Desipramine & a MAOI is how to end up with a hypertensive crisis. MAOI don't reult in more noradrenaline as (I mentionioned earlier) noradrenaline has an inhibitory effect on it's own (and dopamine) synthesis through inhibiting tyrosine hydroxylase.

How do you know you don't have enough noradrenaline, have you been diagnosed or is it your own deduction? What you stated in your last post can be down to a number of conditions that have nothing to do with noradrenaline synthesis
 
This whole thread is worthless and filled with some never before seen degree of nonsense.

99% of it makes no sense.

To recap:

"I need more noradrenaline"

"why?"

"I to tired to explain why, trust me"

"That's not much to go on"

"You idiot"

"Okay, but if you can't give us more info, we can't help you."

"I depressed, and tired, and have not enough noradrenaline"

"Yeah, but from those symptoms you could have all sorts of other disorders unrelated to noradrenaline"

"It from lack or noradrenaline, I no need explain myself"

... various oversimplified, partially accurate statements about why it "has" to be noradrenaline deficiency ...

A few answers

some english that a machine translator would be ashamed of. (and seriously, consider using one and then fixing it up after the translation. I can only assume that the language barrier is getting in the way of getting a decent answer, because if you can't do a thousand times better in whatever your native language is, there's really no way in hell that you should possibly consider self medication. It's said that people should do what they can to make sure their best interest is served by the doctor, but that's people who are intelligent. Really stupid people should stick to letting others treat them. I'd hate to see my mother making medication suggestions, for instance)

Finally:
How do you know you don't have enough noradrenaline, have you been diagnosed or is it your own deduction? What you stated in your last post can be down to a number of conditions that have nothing to do with noradrenaline synthesis
Click to expand...

So finally, you either need to find a way to express yourself better, or talk to someone who can relay your thoughts, because so far, you've given us absolutely nothing to work with.

Actually, you have, I guess, but it's all been indications that you have no idea what you're talking about, and would be best served by listening to just about anyone here, because your rationale, presented thus far is so weak and convoluted that for a rare occasion, everyone is lining up against you.

(also, by the way, when you tell our more intelligent members that they're too dumb for this forum, you only undermine yourself. There's only so much that we can blame on a language barrier, and that sort of stupidity is not one)
 
if you think you are depressed because of a lack of noradrenalin, have you tried good old fashioned exercise? some kind of activity that requires constant focus and quick thinking like racquetball would be good. unless you have some kind of enzyme deficiency your body will make more noradrenaline if you create a need for it.
 
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