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Hexacyclonate

Reminisant B

Reminisant B

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Nov 3, 2005
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Hexacyclonate

Was under stimulants (not sure if this is correct looking at the structure) but it looks to be the GHB version of GABAPENTIN. (or should I say the what GHB is to GABA applied to gabapentin I.e replacing NH with OH).

http://en.wikipedia.org/wiki/Hexacyclonate

There is always an interesting find on wikipedia. [Yeah I know it does have it's inaccuracies sometimes]
 

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Adjunctive treatment of the chronic alcoholic with hexacyclonate sodium.CHESROW EJ, SABATINI R, MUSCI JP, KAPLITZ SE, MARQUARDT GH.
PMID: 13878809 [PubMed - indexed for MEDLINE]

Pharmaco-motivation of the geriatric patient: a preliminary report on hexacyclonate.MORRISON BO.
PMID: 14476295 [PubMed - indexed for MEDLINE]

Effects of hexacyclonate on regressed patients.UDDYBACK OT, CHEN CH.
PMID: 13923435 [PubMed - indexed for MEDLINE]

[Sodium hexacyclonate as coadjuvant in the treatment and rehabilitation of the chronic alcoholic.][Article in Italian]

CHESROW EJ, SABATINI R, MUSCI JP, KAPLITZ SE, MARQUARDT GH.
PMID: 13692926 [PubMed - indexed for MEDLINE]

Can't get any of the articles they are quite old, still interesting compound. From displaying use in alcoholics wonder if it does have some GABAergic mechainism similar to gabapentin/ghb [?] Although there are mentions of it as a stimulant, quite confusing.
 
Doesn't look like much of a stimulant, but doesn't remind me of GHB, either.

Good to know it's a drug in production, though. If one was interested in that sort of thing.
 
Well not sure if it's in production.

..and definately agree wasn't meaning to suggest it has GHB effects, I possibly should have worded it better. :)

However you can see how purely from a chemical perspective hexayclonate is to gabapentin as GHB is to GABA. (replacing NH with OH)

It doesn't sound particurlarly successfull as it was made ages ago and clearly not had much use.

Still interesting analogue of gabapentin though.
 
I had first thought about synthing this maybe a year or so ago, never occured to me someone already had. I searched the IUPAC name and found nothing and never really pursued it.

I wouldn't be surprised if it was brought back in the wake of gabepentin derivatives becoming blockbusters, though.

I haven't tried yet, but I wonder if the prescribing information is available for it. It'd be interesting to know about what sorts of studies were done.

I wouldn't be too surprised to find out that it turns out to be pretty enjoyable, though. I wonder if there's any info about alcoholics abusing it. If it has much similarity to either GHB, Gabapentin or (less likely) recreational stimulants, it'd likely have been enjoyed- probably more than abstinence- the effects.

There was a lot of misuse of words like "stimulant" back when this was being used much. Opiates were often called stimulants (not sure if that was still in use in the 1950s, though), for instance.

I might search this out since it's been such an interest of mine.
 
well it is classed as a respiratory stimulant but i still am thinking it maybe possess the GABAergic antagonistic effects similar to Bemegride as it also notes to being a CNS stimulant i believe
 
Besides the single ring structure, I don't see much similarity between the two to expect similar effects. But there are more distant structures with similar effects, though.

opiates come to mind.
 
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