Hepatic Transesterification

[8L4YN3]

Howdy all.

As we all know, consuming alcohol with cocaine causes cocaethylene to be made via hepatic transesterification. I also just learnt that alcohol and methylphenidate(ritalin,concerta) causes ethylphenidate to be made, a potent psychoactive drug itself.

I can't help but wonder what other drugs consumed with alcohol have a similar effect? Are these the only known instances of this?

 

[sekio]

Any drug with an ester linkage/carboxylic acid group should in theory fornm ethyl esters. Fatty acids do, for instance. But not a lot of drugs have an ester or carboxylate group because they are 1. polar and 2. easily broken down to destroy the drug.

 

[AfterGlow]

As we all know...

Not a good way to begin any statement. It's presumptuous.

 

[8L4YN3]

Not a good way to begin any statement. It's presumptuous.

This is called advanced drug discussion for a reason, i'm pretty sure most cats that roam this particular forum would be aware of this. Stop nitpicking for the sake of it.

 

[Hammilton]

Not a good way to begin any statement. It's presumptuous.

Something similarly useless could probably said about giving unwanted and meaningless advice.

If we can't assume that everyone here is aware of cocaethylene and it's in vivo production, this subforum is falling faster than America

 

[Snowy]

Howdy all.

As we all know, consuming alcohol with cocaine causes cocaethylene to be made via hepatic transesterification. I also just learnt that alcohol and methylphenidate(ritalin,concerta) causes ethylphenidate to be made, a potent psychoactive drug itself.

I can't help but wonder what other drugs consumed with alcohol have a similar effect? Are these the only known instances of this?

Just because this reaction occurs, does'nt say that this happens often enough to produce a significant effect. For cocaine we know it has a significant effect, but for methyphenidate it isn't certain although it has a similar potency. AFAIK there is no reliable data about the BAC and it's relation to the transesterfication reaction in relation to the plasma level of the drug.
You should also take the activity the esterases in account, which varies extremely by ROA.