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Help, psychedelics stopped working for me after 25-x NBOME.

T

t3hST0N3R

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Aug 22, 2011
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4
I've tripped a few times - a few shroom trips, and acid once.

A few months ago I took 2 tabs of an NBOME compound and didn't trip at all, experiencing a uncomfortable comeup and "immunity" to weed, as in trying to smoke copious amounts in order to launch the trip produced zero effects. My friends had tripped on the same tabs before. I thought that it would be no big deal, that I just hasn't taken enough.

My last psychedelic experience prior to this was 1.5g shrooms, well over a month before.

However, one month later I took two tabs of acid, and had the exact same thing: an uncomfortable comeup an inability to get high from weed. My friends tripped moderately. I didn't know what was going on.

A month again after that, I took 4g shrooms and experienced THE SAME THING again. No trip, a couple hours of body lightness and anxiety, then nothing. A friend took 3g of the same shrooms and tripped balls.

Two months later, I took three tabs of acid and once again did not trip, whereas my friend tripped intensely. I actually got visual distortions this time, which lasted for around 15 minutes. I ate a 100mg THC edible two hours in, which should have completely floored me. I felt more sober than ever, except for having extreme short memory loss.

I am losing hope. Psychedelics are so important to me.

What can I do? Should I take a much longer tolerance break? A heroic dose next trip? I've been reading everything I can about NBOME tolerance and perma tolerance, but can't find much information. If anyone knows anything...
 
Hmm I don't know, a month should be plenty of time. Be careful assuming that you are immune and check first with any new batch of psychedelics you will be trying. Can you get a larger quantity of LSD (i.e. that will allow you to first check the potency with friends, and then use the same confirmed acid to titrate until you notice effects). If something feels wrong about what you are doing, stop with the plan and take a long break to allow your body to get balanced again and/or upregulate receptor densities.

You don't want to push it when you are showing signs of getting anxiety issues. Psychedelics are important to me too but I opted to take it easy the last 2 years just to be sure, and to allow myself to restore some proper balance, even if tripping is therapeutic to me... neurologically speaking it is not natural, it's just not baseline.

Perhaps for some reason you are 'stuck' in the downregulated state...

Maybe if you are not against it, you could also try something else like I dont know, 2C-E, and see how you react to it.
 
NBOME's and 2C-E fucked my tolerance in the ass. Don't take any more phenethylamines or even LSD for about 6 months (my recommendation, however anywhere from 3-9 will be good). Stick to tryptamine trips very rarely... once every few weeks at the very most. 6 months of this and your psychedelic tolerance will be gold. Then you can go back to doing high potency psychedelics, but remember to limit them to at most 1 a month, and general phenethylamines like 2C-E once every 3 weeks at the most.... but not both. If you're tripping every week you're going to fuck yourself over, if you're tripping every week on NBOMEs you will WRECK your tolerance and risk never having those magical 25C trips again.

This is based on extensive personal experience with said drugs (aside from LSD).

Someone may disagree with this information but I believe I'm correct. I suggest you follow my advice OP and maybe even wait twice as long as I said. Remember to never constantly redose psychedelics, never do them the next day or week, never use them for stimulation instead of tripping. You can do all of these but you HAVE to be very careful or you'll not only fuck your trips up, you'll be depressed and out of it like someone who does MDMA too often.

Watch out for NBOME big time and remember this is all opinion based on personal experience. To match your story, my friend kept trying increasing amounts of 25C every day and he never tripped. He kept taking more in an attempt to get the real trip. The last dose of this binge was a whopping 40 mg dose insufflated and the only reported side effect was joint pain. No trip, slight stimulation and euphoria. 35-40~ mg 25C-nbome slowly titrated. (No one bring up HR just read this all carefully) The point is that constant dosing of small amounts will never give you the trip you want. You need to wait until you have NO tolerance and dose according to widely reported dosages (600 ug for 25C) and do it in one dose. Constantly redosing and trying to do more to account for tolerance can also be very dangerous. My friend titrated his dose carefully over time so he could tell there were no effects so he tried more and more still none (except joint and bone pain which is a side effect of vasoconstriction correct?) It's very irrresponsible, risky, and it can lead to accidental overdose to use drugs like that ( I do not condone a 40 mg dose or even a 4 mg one)

Anyway, hope this little rant was informative to you, and if I fucked up any sentences please excuse me Ive been up 34 hours with no drugs except weed and I also worked a 14 hour shift.... so you better appreciate this post. Took a lot of effort in this state of mind. Hope your tolerance gets better, follow my (opinionated and not necessarily factual) advice and you'll be golden.

Happy tripping and good night.
 
2002Tii said:
Just for curiosities sake: you aren't on any medications by any chance are you?
Click to expand...

I'd like to know this too. Seems like whichever NBOMe you took that didn't work very well either, which makes it quite possible that whatever's causing your inability to trip properly occurred/began occurring before that trip.

Certain medication like SSRI anti-depressants, and anti-psychotics, can reduce or even completely block the effects of psychedelics. Some other medication like benzodiazepines can weaken the trip.
 
Thank you all for your replies.

I am not on any medication and never really have been.

bloodshed, the point about the phenethylamines is interesting - perhaps I should also mention that I have also taken MDMA twice to no effect (I had dilated pupils, literally nothing else), while my friends rolled balls. I may have a natural high tolerance but my serotonin system may also be fucked. Does this imply that the NBOME fucked my serotonin receptors so hard that all serotonin-affecting compounds will no longer work?

I am two months in from my last trip that didn't work (three tabs on New Year's Eve). I guess I'll take another four off...

I have also discovered some information about magnesium supplements playing a role in mitigating tolerance. If anyone knows more, this seems like a possible course of action.
 
No I do no other drugs besides cannabis. Theres nothing else interfering with my serotonin receptors. If you believe my information is somehow flawed, ask me specifics and I'll explain further. I believe theres lots of misinformation about NBOMEs on this site and I wanna fix it.
 
You had to make this post on reddit in every drugs sub there, and then here? Dude, everyone there already told you what you need to do. Stop taking psychedelics. Forcing them on yourself is not safe nor logical for figuring this out. You did something and should let your body and mind heal.

It's like people post to all these places until they find answers that suit their own tastes... like use common sense for fucks sake.
 
Am I at fault for wanting to find out more about my situation?

To see if anyone else is experiencing the same thing?

To find others in the drug community who have any knowledge about a novel research chemical? Everyone seems to have "heard" of perma-tolerance related to NBOMEs, but there is so little actual information about it, anecdotal or otherwise.

Why the fuck do you think I posted this in multiple places? People in other places with a more advanced knowledge of pharmacology were actually able to give some pointers about how perhaps to help out. Googling didn't help. Searching within multiple forums didn't help.

All I want is to trip.

I'm looking for any answers at all. Why would I be bothered with an answer that suits my own tastes.
 
IMO you are not at fault for bringing it here and discussing it.
But it seems flawed to me that you still "want to trip".

I've been frequenting this forum for a while now and a trend I often see is that people often don't accept the advice they get, probably because it is confronting. That doesn't make it bad advice, and asking for more advice doesn't change anything about this.
The best way to help yourself now is stop taking these compounds for a while. There are several people popping up who suffer consequences from NBOMe compound use. It doesn't take a genius to figure that out and all the pharmacology knowledge in the world is probably not going to change this. Yes I'm theoretically interested in what happens to receptor densities involved and stuff like that, or why full agonists would have such big repercussions compared to partial agonists. But come on, is that really what you are looking for. I don't believe that. You would probably be most interested in a justification or a way out that, as you say, would still allow you to trip since that is "all you want".

Why would I be bothered with an answer that suits my own tastes.
Click to expand...

Do you mean: "Why would I be bothered with an answer that does not suit my own tastes." ?


In general, exposure leads to desensitization. The solution is typically to stop the exposure. Full agonists probably are a more extreme form of exposure that somehow signals a stronger tachaphylactic response. NBOMe's are more potent and lead to more tolerance and more desensitization. Get it?
The LSD thumbprint story could fit in there, but that is probably complex because of the acute intensity and perhaps more elaborate pharmacodynamics.

If you want to trip again, avoid NBOMe compounds - for a while avoid all other serotonergic drugs - then slowly check with 'lesser' psychedelics if you can trip again.

Ask people with massive opiate or dissociative tolerance (I am one of the latter): can you ever get the magic back? It is doubtful, but if you do, stopping for a long time and only continuing with extreme moderation is probably the only thing that could lead to a satisfying experience once again.
 
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You might like to check out the massive shroomery thread that the link links to, it's all about the thumbprint experience.

I understand - that is true, I am searching for a way out, anything that might allow me to trip apart from abstaining such a long period as more than six months.

I mean I am looking for answers at all, whether they suit my tastes or not. If I may never be able to trip on psychedelics again, I would like to know. If there is anything I could do to increase my chances of tripping, I would like to know.

Right now the most promising thing seems to piracetam and magnesium supplementation. And, of course, a prolonged period of abstinence.

I have never dabbled with truly high doses of psychedelics, so I don't understand the massive tolerance off this once batch of NBOMEs that has seemingly fucked me over for so long.

I have experienced a kind of "permanent" tolerance related to the "magic" with ketamine (my experimentation with dissociatives was years ago). After my first couple of k-holes it became incredibly difficult to k-hole without a really huge dose, and the k-hole wasn't as...immersive. The inability to k-hole properly or deeply persisted even after 6 months, and after another disappointing k-hole I stopped using the drug. I was never interested in the threshold or recreational effects. But I do understand completely about this phenomenon of permanent tolerance.

Tangentially, I wonder if this applies to all classes of drugs. After my experimentation with meth (also years ago), using other stimulants at low or "normal" dosages only calms me down and makes me really chill; I have to take a whole bunch more in order to tweak at all, or get to the euphoria zone.

What "lesser" psychedelics or non-serotonergic psychedelics could you recommend?
 
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doomsdayguy said:
You had to make this post on reddit in every drugs sub there, and then here? Dude, everyone there already told you what you need to do. Stop taking psychedelics. Forcing them on yourself is not safe nor logical for figuring this out. You did something and should let your body and mind heal.

It's like people post to all these places until they find answers that suit their own tastes... like use common sense for fucks sake.
Click to expand...

Ha! I knew OP's post seemed familiar. /r/DrugNerds couldn't help you eh?

If you want to trip again try taking some dissociatives. Mix it up man.

dissociatives = non-serotinergic. Get some MXE, 3|4-Meo-PCP or something.
 
From reading this thread I think you are jumping to conclusions in blaming the NBOMe.

I think it is more likely there is some other cause which also prohibited the NBOMe trip.
 
t3hST0N3R said:
I have never dabbled with truly high doses of psychedelics, so I don't understand the massive tolerance off this once batch of NBOMEs that has seemingly fucked me over for so long.
Click to expand...

You don't seem to understand that NBOMes are research chemicals and not "magical molecules." We don't know what the long term effects are, and there's a lot more cases popping up of people developing HPPD from this chem. 5HT2A receptor activation is known to cause psychosis given enough activations and time. 25i COMPLETELY agonizes this receptor. Is it really worth it?

I have no problem discussing this here, my problem with OP is exactly what Solipsis said:

"But it seems flawed to me that you still 'want to trip'. I've been frequenting this forum for a while now and a trend I often see is that people often don't accept the advice they get, probably because it is confronting."

You're just going from place to place expecting an answer that suits your needs, not listening to people telling you to stop doing drugs for awhile. Hell, supplementation is something I would shy away from. Let homeostasis do it's damn thing.
 
t3hST0N3R said:
bloodshed, the point about the phenethylamines is interesting - perhaps I should also mention that I have also taken MDMA twice to no effect (I had dilated pupils, literally nothing else), while my friends rolled balls. I may have a natural high tolerance but my serotonin system may also be fucked. Does this imply that the NBOME fucked my serotonin receptors so hard that all serotonin-affecting compounds will no longer work?
.
Click to expand...
Yes, I definitely think it is related. Remember that MDMA shouldn't diminish your nbome trips to any great extent (afaik) but the inverse could definitely be true. nbomes were literally designed to be super potent 5ht2a tolerance agonist assholes. That and the fact phenethylamines, NBOMES, and tryptamines all have different tolerance buildup.
Cface said:
Ha! I knew OP's post seemed familiar. /r/DrugNerds couldn't help you eh?

If you want to trip again try taking some dissociatives. Mix it up man.

dissociatives = non-serotinergic. Get some MXE, 3|4-Meo-PCP or something.
Click to expand...

MXE is serotonergic if I recall correctly, or maybe that was just a popular rumor. 3-MeO-PCP is definitely serotonergic, and I think 4-MeO-PCP is as well.
 
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