Opioids Help me calculate the actual dosage of 120mg that gets into my system (oxycodone)

[evo4ever]

Hello all.

I'm planning on taking 120mg of Oxycodone but I've just realised that 120mg won't actually reach my brain. I'm taking 4x 10mg capsules and 4x 20mg capsules. It says on the 10mg box that it contains 9mg and the 20mg box contains 18mg so that's 108mg. Then I've got to factor in bioavailability which is about 70% for Oxycodone. So the actual dosage that reaches my blood stream is around 75.6mg! It feels like I've been conned lol. Are my calculations right?

PS: Don't worry I'm opioid tolerant.

 

[Them Witches]

The only way to get custom dosage applications is through pain management programs where they test your system for how you process it. Then determine if increasing the dosage is needed.

What your describing is just how the PO route goes. IV is the only way have top plasma levels of Oxycodone.

If you are not in pain management, I would not bring this topic up to the doctor unless you have been on Oxycodone for a considerable amount of time (5-10 years). Doctors also need scientific proof in cases like this and from what I know they only do it in legit pain management.

If you need to go up on your dosage, I would wait a year or so to request a legit medical titration by saying "it's not working"... Bounce the ball back to the doctor to make his "big decision." If you lean on the doctor too much, they may put you on Oxycotin OP which blows ass compared to IR. Oxycotin creates lower blood plasma levels compared to IR taken every 4hrs and the brand name costs considerably more.

There are ways to increase blood plasma levels of Oxycodone. They are OTC Tagamet 200 (Cimetidine "acid reducer"), on an empty stomach take TUMS before dosing, grapefruit juice, and certain steroids. I have found the best way to increase the effectiveness of Oxycodone HCl IR is dissolving it under the tongue. In order to do that it cannot be Rhodes (RP) -- . Mallinckrodt (M-30) or Activas (K-9) brands work the best. Taking it with Clonidine HCl is a game changer.

This link is helpful :

ClinPGx

www.pharmgkb.org

 

[evo4ever]

The only way to get custom dosage applications is through pain management programs where they test your system for how you process it. Then determine if increasing the dosage is needed.

What your describing is just how the PO route goes. IV is the only way have top plasma levels of Oxycodone.

If you are not in pain management, I would not bring this topic up to the doctor unless you have been on Oxycodone for a considerable amount of time (5-10 years). Doctors also need scientific proof in cases like this and from what I know they only do it in legit pain management.

If you need to go up on your dosage, I would wait a year or so to request a legit medical titration by saying "it's not working"... Bounce the ball back to the doctor to make his "big decision." If you lean on the doctor too much, they may put you on Oxycotin OP which blows ass compared to IR. Oxycotin creates lower blood plasma levels compared to IR taken every 4hrs and the brand name costs considerably more.

There are ways to increase blood plasma levels of Oxycodone. They are OTC Tagamet 200 (Cimetidine "acid reducer"), on an empty stomach take TUMS before dosing, grapefruit juice, and certain steroids. I have found the best way to increase the effectiveness of Oxycodone HCl IR is dissolving it under the tongue. In order to do that it cannot be Rhodes (RP) -- . Mallinckrodt (M-30) or Activas (K-9) brands work the best. Taking it with Clonidine HCl is a game changer.

This link is helpful :

ClinPGx

www.pharmgkb.org

I'm from the UK so I'm not subject to "pain management contracts".

 

[Them Witches]

I'm from the UK so I'm not subject to "pain management contracts".

hell yeah

 

[Keif' Richards]

Hey there @evo4ever good to see you and talk to you. It's been a little while.

What you're describing is a little-known piece of pharmacology relating to the salt to which the freebase of a given Opioid will be bound. For solid tablets to be created, the easiest way is to synthesize the drugs as salts I.e. Oxycodone Hydrochloride or Morphine Sulfate. In bold you will see a couple of the most common salts used. This means that when you have a 10mg Oxycodone tablet, this often means ~10% of the total weight will consist of the salt the freebase is bound to. This is completely normal, though this is not commonly written on pharmacy products here in the United States.

Oxycodone has a bioavailability of ~85% via the oral route. It's one of the most bioavailable of the commonly-prescribed Opioids.