I find it hard to believe that these effects could be contributed to marijuana use alone. You mean to tell me that these subjects never drank alcohol, ingested first or second-hand cigarette smoke, took herbal supplements tainted with heavy metals, ate improper diets off of lead-glazed dishes, had mercury amalgam fillings in their mouths, had pre-existing genetic disposal to mental illness, etc. etc.?
Human subjects, no matter how large the population in the study, usually have too many other variables going on to attribute certain effects to a given cause. You really can have no "control" in this study because you're not putting these people in a room, observing them 24 hours a day, administering precise doses of marijuana, and making sure they all live similar lifestyles OUTSIDE of pot (diet, sleep patterns, etc.). Also, 20 years is a long fucking time. Who's to say that brain shrinkage doesn't occur naturally to some degree as we age? (I'm about 90% sure I've read that it DOES).
Anyway, not discrediting the study because weed is my DOC: it's not. I don't doubt it affects the brain, I just doubt its effects on brain size and the ability to measure it over time with so many other possible variables, especially in a group this small. I've never heard of such a small population being used in a study before! 85 patients is considered insignificant by some standards for testing new medications, but FIFTEEN?
Exposure to heavy metals like lead and mercury that we all get EVERYDAY (some more than others through vaccines containing Thimerosal, mercury fillings, lead-containing jewelry/dishes/toys/paint, fish consumption, occupational exposure, etc.) is known to cause significant changes in the way the brain functions, as well as changing electrical impulses within the brain; it's even been linked to some of the more horrific neurologic conditions that are on the rise today: Parkinson's, Alzheimer's, MS, Autism...Who's to say it wasn't this type of exposure causing the changes seen in the study? That's only ONE example of possible brain-damaging exposure. There are many more that I'm sure weren't accounted for in this study.