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Hazardness of this combo? Left 1 dead

N

notgenuine

Bluelighter
Joined
Apr 20, 2013
Messages
35
Hello.

A close relative of mine passed away a few days ago, and it's not yet clear what and how much she had took different pills + alcohol. It wasn't a suicide, but she was having 'fun' with her friends and taking some booze and pills. The current guess is that she had 20mg of oxycodone, several mg's of alprazolam, 300mg of pregabalin and several cans of beer. She was 'OK' but dizzy and fuzzy, and was put asleep after hitting her head, and next morning was found dead.

What is your opinion on the hazardness of this combo for a young woman with no tolerance for opioids or pregabalin (Lyrica)? Everyone expected she to tolerate those dosages with no problems, and so care-taking failed with this horrible result.
 
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^I'm upset to hear about your relative, NG.

That combination, to someone with little to no tolerance, is easily fatal. All the drugs mentioned synergize with each other. That dose of alprazolam(Xanax) and the alcohol alone are very dangerous, as can the pregabalin and alcohol, the alprazolam and oxycodone, etc.

Whoever gave her this, or allowed her to dose this knowing her tolerance was criminally negligent IMO.

<3
 
I'm so sorry to hear about your relative :(

As others said, if someone has a low (or no) tolerance to the substances in question that combination could definitely be fatal because they are all central nervous system depressants. On this site we regularly caution people not to take such combinations.

Venrak said:
Whoever gave her this, or allowed her to dose this knowing her tolerance was criminally negligent IMO.<3
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It's very possible that they didn't know it was dangerous. If she was doing it with friends who had a high drug tolerance they may have just assumed she could handle it also, (not that anyone should make that assumption but the fact is that people often don't realize that we are all so different and that both natural sensitivity and acquired tolerance play a huge role in the risk level).

Hitting her head could have been a contributing factor as well.

I had a friend die from taking the same amounts and combination of drugs/alcohol as she had taken on previous occasions; no one thought she would be in danger that night since she had done the same and been fine in the past. The lethality of a given combo and dosage can vary depending on the person, the situation and environment, if/what they eat, and so many other factors. It's always best to err on the side of caution.

It's also very possible that the people she was with did not know exactly what doses of drugs she took or quantities of alcohol she drank. The OP mentioned it was the "current guess". We don't know the circumstances.
 
You said she hit her head and someone let her go to sleep? The same thing happened to my moms friend.. When she was on pills, she fell and hit her head, and the people she was with just let her sleep. The M.E said she would've lived if they had taken her to the hospital. So more or less it was probably the combination of pills and hitting her head that did it.
 
Sorry to hear about your family member. From my experience with opiates and lyrica a person that has never had any opiate would probably nod off with 20mgs. Lyrica, I've seen people take 100mgs and act drunk as hell. I'd say the oxy with alcohol was the main killer in this alcohol.
 
Swimmingdancer said:
I'm so sorry to hear about your relative :(

As others said, if someone has a low (or no) tolerance to the substances in question that combination could definitely be fatal because they are all central nervous system depressants. On this site we regularly caution people not to take such combinations.


It's very possible that they didn't know it was dangerous. If she was doing it with friends who had a high drug tolerance they may have just assumed she could handle it also, (not that anyone should make that assumption but the fact is that people often don't realize that we are all so different and that both natural sensitivity and acquired tolerance play a huge role in the risk level).

Hitting her head could have been a contributing factor as well.

I had a friend die from taking the same amounts and combination of drugs/alcohol as she had taken on previous occasions; no one thought she would be in danger that night since she had done the same and been fine in the past. The lethality of a given combo and dosage can vary depending on the person, the situation and environment, if/what they eat, and so many other factors. It's always best to err on the side of caution.

It's also very possible that the people she was with did not know exactly what doses of drugs she took or quantities of alcohol she drank. The OP mentioned it was the "current guess". We don't know the circumstances.
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The fact that it was said in the OP that the people present were expecting her to tolerate the doses she had taken indicates they were aware of the amounts. That isn't to say that she couldn't have taken more in private, but given the fact that the OP said the subject's tolerance was low, and the current conclusion on the dosages taken, which was obviously drawn by what the people present were aware of, there is liability. Whether the law believes there is or not is another matter, but in my mind there is.
 
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ugh i hate to hear about people who OD. it saddens me! if i was with that girl i DEFINITELY would have kept an eye on her. the girl is partly at fault by not knowing what she was ingesting or the risks that come with drug use, but also the person who gave her the drugs..
 
That can definitely be a deadly combo. I remember having no tolerance and 1-2mg alprazolam combined with 10mg oxy and lots of weed felt extremely heavy for me. I couldn't walk steadily and was super pale, i just felt like even .5mg more of xanax woulda put me out. How ever i mix xanax and alcohol all the time, you just really have to know your body and tolerance. Best not to mix downers with downers, or stimulants with stimulants.
 
Should I punch in the face that guy (her boyfriend) that let her dose all that shit, knowing her tolerance and previous complications with pills?
 
notgenuine said:
Everyone expected she to tolerate those dosages with no problems
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That's a helluv a way to gain an education on the synergy of CNS depressants. :(

(The "everyone" I'm sure didn't include any respectable doctor or pharmacist, who would know this. When my wife had a prescription for Percocet after a surgery, "AVOID ALCOHOL" was a pretty big bullet point.)
 
notgenuine said:
Should I punch in the face that guy (her boyfriend) that let her dose all that shit, knowing her tolerance and previous complications with pills?
Click to expand...

Man, my intention was definitely not to get you all riled up, but I understand where you are coming from. Understand, though, that her death was not intentional. Ignorance isn't an excuse though in my eyes.

Violence won't solve a thing. Might make you feel better at first, but trust me that's a big "might".

Send me a private message via the link in my signature, and I've also got an AIM account (click the little AIM buddy under my location) if you want to talk about this in a more private forum.

Stay safe.
 
I agree with Venrak on everything he said as well. It's disappointing to hear about blatant negligence when it comes to coaching others on how to use drugs. If you don't know your HR, don't hand others drugs.

As he also mentioned, pregabalin (lyrica) increases the effects of benzodiazepines, and alcohol substantially. The mix of powerfully potentiated gabaergics and opioids is probably what resulted in the unfortunate situation.

Sorry for your loss.
 
Sorry to hear about your loss. Definitely a shame to hear of any OD, regardless of the circumstances.

As everyone else said, that combination of drugs can be highly lethal to someone with no tolerance. Opiates and benzodiazepines alone are very dangerous to take together. You literally stop breathing in your sleep from the CNS depression. Add alcohol on top of it, and you're certainly on your way to dying in your sleep from respiratory depression.

Everything in the combo was very dangerous to combine unfortunately.
 
Any combination which affects both the GABA and Opioid receptors should be treated with extreme caution. Mixing opiates and CNS depressants like alcohol, GHB, benzodiazepines, barbiturates or gabapentin/pregabalin when someone does not know their tolerance is a big NO NO.

Whoever gave this to her should be taken to task.
 
Terrible combination for someone with no tolerance with added extra bad luck since the dosages wasn't that high :/

I'm sorry to hear this :'(
 
Today we saw her (in a coffin at forensic pathology institution) for the last time. She did not look like my young little sister. They have opened her skull I guess. Good bye my only full sibling, little sister. She always wanted to help me with my drug and alcohol addictions and other problems.

Be careful with pills!
 
I am so sorry! After reading most of these posts, the consensus seems to be the oxy and beer did it (and the hit) but I just think she ran into a "perfect storm" of circumstances. Even with an opiate naive person, I really have trouble believing it and a few beers would kill someone. All I can think is it and the Xanax and especially the hit on the head created too much for her system. Not to be brutal and all, but it sounds like they did an autopsy. What did they say did it? I realize sometimes it's hard to pin down but...

Again, I am so sorry you're going through this and I wish you and your family all the best!
 
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