Opioids Hate Tramadol/Vicodin, Will I Hate Kratom??

[《Plasticity》]

That's it? That's your response? Easy to cop out when you completely ignore and fail to respond to the post at hand, but it kinda shows your cards I guess. Since the OP gave me the greenlight I'll bite . You made an unjust claim and touted it as fact, so I asked for you to back up your claim. Instead you decided to spout out whatever you could, even false information to avoid giving a source on your claim so I voiced not only my opinion, but general, rather common knowledge that would debunk some claims you made, I say "claims" because not even you knew what you were claiming... naming shit like "serotonin agonist" "wait serotonin antagonist" "no, SSRI/SNRI" and then to just "SNRI".

Examples of the common knowledge I speak of is the downregulation at 5-ht2a if kratom were to truely contain any 5-ht2a antagonists and the complete lack of any serotonin syndrome occuring from an kratom and MAOI consumption, as well as the lack of negative interaction associated with kratom in conjuction with most classes of drugs which would be potentially deadly if kratom "works on serotonin just like tramadol". If kratom worked on serotonin in the same way as tramadol, why aren't there more people than just the handfull dropping dead from kratom combos? It's certainly more popular then it ever was...

Remember who was the one who made the claim, if logic just happens to question or possibly even debunk your claim altogether then be prepared to provide evidence for your claim, not false information (the fake deaths) and personal anectdote that doesn't fall in line with most, if not all kratom users (the SSRI withdrawals from kratom). By your logic, I might as well go ahead attributing pharmocological profiles to poorly understood drugs because it hasn't been proven.

From henceforth I now declare gabapentin, a dopamine agonist with potentially dangerous 5-ht2b activity, and let's go ahead and throw some psychedelic activity at 5-ht2a.... you know, until it's debunked for good . Probably can be, so possible poor example, but you get the jest... now if you will excuse me, I may now proceed to enjoy my steak...

 

[zzz101]

i kinda think kratom does some have anti-depressent effect. but opioids can.

but i think there is something extra with kratom , like with Tramadol.

 

[《Plasticity》]

Of course there's something else going on with kratom, only three of the 24? alkaloids display mu agonist activity...the rest consists of all sorts of other stuff ranging from mu antagonists and calcium channel blockers to adrenergics/stimulants and yohimbine like alkaloids, which the latter two personally sound far more reasonable for these effects than SSRI activity. Yohimbine itself is used as a depression remedy after all. It just seems that all logic points to no SSRI activity.

This claim comes to be from personal opinion on it's effects, typically from standard opiate users who use "clean" full agonist opioids and not dangerous or deadly common interactions that would give light to the possibility of these effects. I think lack of consistent interactions and the fact that people (except for Scotched lol) don't get SSRI withdrawals from quitting kratom is a vital thing to consider when attributing SSRI activity to a drug/plant whatever that hasn't been researched enough rectify the claim.

 

[HdoubleODeezy]

I think some people get the speediness from kratom due to norepinephrine increase mixed with speediness of some antidepressant activity.
I think kratom feels like tramadol, only because of the fact it can be a speedy type of high like tramadol.
I do not however think kratom has *notable enough* action on serotonin requiring a label such as antagonist, agonist, SNRI or SSRI.
Even if it does poses said properties, they would be in such trace amounts that I personally don't think would matter. Hence not needing a label as I said.
Just my .02
I agree with Captain Kratom.

Coffee helps me with my depression by making me more alert and productive.. does that make coffee serotogenic? Maybe it is to a point.. but you don't see it being sold in stores as an antidepressant.. that's what my point was with saying this.

-HOOD