Ok, so far these are my thoughts, but this is all hypothetical.
I personally think it should be fine if he doses low to see how it feels before going any higher. I'm thinking the MAOI activity should only become significant at high doses and I've read that T2's isn't as strong as T7's.
Also I read here that someone took 30mg T7 while on Paxil 20mg with no ill effects though the T7 effects sound reduced.
I do have on-hand both periactin (cyproheptadine) and seroquel (quetiapine) which are both anti-serotonergics - or serotonin antagonists. Periactin is actually used in the treatment of mild to severe serotonin syndrome.
I wonder if he took small doses of periactin throughout it would protect against the remote possibility? And if at the first sign of discomfort he were to take more periactin and maybe also seroquel... or we could just have the two on hand in case.
I also know that there are people, some I've read about on this forum, who mix T2 and even T7 with MDMA with no ill effects even in the face of the possible danger or they did not know. Surely a low dose gradually increased over several hours would be ok if done carefully?
Maybe some MAO inhibition could be bypassed with insufflation, since it wouldn't pass through the gut? Not sure if that's relevant.
Another possiblity is to try a cocktail of 5mg T2, 20mg 2C-C, and 15mg 2C-D, - perhaps this limiting the T2 to 1/3 of the potency is the way to go! Would likely work this up a little and see how we go.
I've had great success before mixing T2, T21 and 2C-E at 5mg each.
Any input?