Has anyone had personal experience with Nucynta/Tapentadol

[megansafox]

Nada from Nucynta

Just tramadol and SNRI combination. MDs have been trying to use SSRIs for pain relief for a while (Cymbalta). Tramadol combines the psychoactive & toxic properties you could find in Tylenol with about the same level of pain relief.

Perhaps some people respond but I found it worthless

 

[El_Toro]

Mmm, so no serotonergic action? One of the attractions of Tramadol is that it does more than mu agonising.

 

[Xamkou]

ACMD advise that it be made class A.

 

[trainof4]

Definitely has potential for addiction IMHO. I recently quit using dilaudid & needed Sub to do it - now worried that when this runs out/ I'm using much more than I should each day. When I first took it, well the first few doses, I would vomit rather violently. Minimal nausea before I started puking which I found odd. It's something to look out for just in case - would hate to read about anyone barfing all over themselves.

Have gone through a bottle of 100 since Tues 31st Aug. Hoping that in spite of qty taken during this time frame that the short duration (1 week basically) will make withdrawal less likely when I run out.

Has a pleasant buzz -for me anyway - definitely different than dilaudid - but still a buzz. I didn't get any of the energy rush that I've read in other posts. I get very sleepy. When injected it has an odd sort of electrical, cold sensation in my neck & face. Also - on injection - immediately after anyway, m privates get a rush, a sort of hot feeling. It's exactly like when I have had CTs that required contrast. The contrast does the same thing - not sure why the Nucynta would do this.

Feel like I traded one devil for another though - I can't seem to convince myself to NOT take another dose as frequently as I do. Not sure if it's psychological or physiological. Something else others might want to consider.

It's also extremely expensive & my insurance wouldn't cover it - too new I guess.

 

[shade404]

I've taken tramadol and Nucynta at low to medium doses, and thought Tramadol was definitely longer acting, more powerful and more fun. Is Nucynta an S-II because you can dose escalate in a way that's less possible with tramadol? I first read that Nucynta was developed as a synthetic molecule that's closely related to a tramadol metaboite, so I thought it was very strange to see it shot into S-II when tramadol isn't even controlled over here.

 

[Hammilton]

it's because nucynta's mu affinity is so much higher than tramadols (and that tramadol is effectively a prodrug for the desoxy metabolite)

 

[PoppyLlama]

I have a script for nucynta and personally I like it alot. You can definitely catch a nod off of it, and it has a really nice body high, kinda like heroin or hydrocodone.
I am trying to figure out a way to potentiate it, I started out taking 200 mgs per dose (to get high, if im not getting high then i just take 100mgs for pain) and just earlier today i popped 10 of em and a 15 mg ER cyclobenzaprine. I feeel soooo good right now. If anyone has questions about it ill be glad to try to help


and hey loveandtheft i bet you would have gotten pretty high had you taken like 4-6 of them

 

[bicycle-ride1943]

I have a script for nucynta and personally I like it alot. You can definitely catch a nod off of it, and it has a really nice body high, kinda like heroin or hydrocodone.
I am trying to figure out a way to potentiate it, I started out taking 200 mgs per dose (to get high, if im not getting high then i just take 100mgs for pain) and just earlier today i popped 10 of em and a 15 mg ER cyclobenzaprine. I feeel soooo good right now. If anyone has questions about it ill be glad to try to help


and hey loveandtheft i bet you would have gotten pretty high had you taken like 4-6 of them

I totally agree with you here. I think because it's something new and people see that it's structurally similar to Tramadol they just right it off as junk. I was originally on Tramadol for my back injury 50-100mg every 4 to 6hrs as needed. Got changed to Nucynta 100mg 4x a day, hands down flat out better than Tramadol (although I realize everyone has their preferences). With high dosages of Tramadol I would get very jittery. Nucynta gives me energy, makes me very engaging and talkative and in general being really interested in whatever I was doing or what was going on. In my opinion better than Ultram, Percs, Vics etc. etc. I like the way it makes me feel better, I like the fact that there are a lot less side effects, and I like the fact that it can completely eliminate what would otherwise be 24/7 miserable back pain.

Let me know what you find out about a potentiator. I also receive 4mg Tizanidine along with the 4 100mg's a day, but I haven't tried it because If I take 8mg of Tizanidine I'm out...makes me really drowsy. I mainly want to find a way to make it last longer. For example, would 2 100mg's taken at once last longer than 100mg and then an hr later another 100mg? I think I've noticed that If I eat a small meal or snack 10-20min after dose it comes on sooner and seems to last a bit longer, but this could just be placebo.

Interactions- I've had no problems taking Nucynta along with 3mg a day Alprazolam ER(anxiety) and 50mg Vyvanse(ADHD). In fact, I think they're pretty nice together. But, just because these combinations are safe for me, it doesn't mean it's safe for anyone. Please always talk to your Doctor so he can weigh the benefits/risks.

 

[PoppyLlama]

I have a script for nucynta as well, and i have taken up to 500 mgs (didnt turn out real well, had weird hallucinations) although ive found 400 mgs to be the sweet spot, i get quite high, sometimes ill catch a nod depending on how tired i am, but sometimes not, however, there is definitely a good body high aspect to the medication, as well as the classic opiated feeling, the SNRI effects are undesirable for me but i put up with them. If I take my 10mg cyclobenzaprine with 400mg tapentadol i definitely catch a nod.

Although I can get high, I do not get any pain relief from this medication anymore--since this is my primary use for it, i am quite unhappy.

Now i have a feeling this medication would be much better if used in combination with another opiate, as a potentiator. I will be changing medications this month either back to morphine or on to oxycodone or hydromorphone. not sure whats gonna happen although im hoping for some roxys. I will report back on the usefullness of it as a potentiator for other opiates.


EDIT: I also wanted to add that a couple days ago i snorted 0.5 mgs suboxone--and later that night (less than 12 hours later) i took 400mgs nucynta, and got quite high. It could be due to the small dose of suboxone i took, or it could be that the binding affinity for the mu receptor is higher than that of buprenorphine? i dunno, researching currently

 

[Slapdragonx]

Watch out for tolerance to the cyclobenzaprine. Trust me, tolerance can build. It scares me that I can now take 60mg of cyclobenzaprine and not feel anything.

 

[Mr. Tambourine Man]

I was just recently prescribed Nucynta for ongoing arm pain, possibly caused by nerve damage. In my opinion, Nucynta has a novel blend of effects for an opioid, as well as a pleasantly long duration (5-6 hours IME).

I think the effects could best be described as a mixture of a large dose of hydrocodone and tramadol; and not just because its structurally related. The first hour definitely gives a slightly compulsive (but pleasant) sociability, similar to the initial effects of tramadol, while gradually developing a more sedating quality with a body high almost identical to hydrocodone, but even "warmer". Also, its not terribly sedating, and does not seem as likely to induce a nod as, say, oxycodone (which by the way I feel is much inferior to Nucynta both in terms of pain relief and euphoria).

Also, it seems to cause a very slight tendency to misinterpret objects you look at, particularly in your peripheral vision. For example, at least five times today I've seen small objects like chunks of gravel or raisins which I thought for a second looked like moving insects (similar to a low dose of some deliriant...not unpleasant, just a little confusing).

Finally, I think I should mention that since the first time I've taken Nucynta, I've also been wearing a 25 mcg Fentanyl patch. However, the patch on its own has little to no effect besides dulling the pain, so I doubt its making much difference. IMO Nucynta is far and away THE most effective painkiller I have been given since my pain began (more so that Oxycodone/contin, Tramadol, Fentanyl, and even IV Dilaudid in the ER). I hope that this gets wider distribution in the next decade; I feel this could really be a lifesaver to some people.

 

[PoppyLlama]

Also, it seems to cause a very slight tendency to misinterpret objects you look at, particularly in your peripheral vision. For example, at least five times today I've seen small objects like chunks of gravel or raisins which I thought for a second looked like moving insects (similar to a low dose of some deliriant...not unpleasant, just a little confusing).

if you look up "nucynta/tapentadol hallucinations" you will read that at a high dose of nucynta (500mg) i had strange hallucinations which included: seeing cats in the road while being driven by a friend, when there were no cats; seeing people in and around a car where there were none; seeing other animals which were not there, seeing silhouettes of people outside which were merely trees or bushes or shadows. im sure there were others but i dont remember them at the time

its really weird, im not sure what causes it, but i also notice a slight misinterpretation of objects (like those you mentioned--thinking something is a bug or spider when its just a pebble or spec of dirt) at lower doses ~100-200mg

 

[Mr. Tambourine Man]

Yeah, I noticed that at a higher dose things got REALLY weird. When I closed my eyes I would see lines of text, formatted like scripts, bulletins, etc, with fully coherent sentences (and when I say i saw the, I mean as though my eyes were open staring at the computer screen)

Sometimes there would also be voices narrating the script, and discussing meaningless scenarios, like how to build an anteater out of caramel toothpicks (no shit). Also, there were other totally random CEV's (dancing hands, collapsing balloons, and people climbing up walls, to name a few)

I would say the CEV's were on par with a 2nd+ plateau dose of DXM or a medium dose of ambien, completely photo-realistic, and VERY immersive. Of course, now I wonder what the hell this is doing to my brain...

 

[bicycle-ride1943]

Yeah, I noticed that at a higher dose things got REALLY weird. When I closed my eyes I would see lines of text, formatted like scripts, bulletins, etc, with fully coherent sentences (and when I say i saw the, I mean as though my eyes were open staring at the computer screen)

Sometimes there would also be voices narrating the script, and discussing meaningless scenarios, like how to build an anteater out of caramel toothpicks (no shit). Also, there were other totally random CEV's (dancing hands, collapsing balloons, and people climbing up walls, to name a few)

I would say the CEV's were on par with a 2nd+ plateau dose of DXM or a medium dose of ambien, completely photo-realistic, and VERY immersive. Of course, now I wonder what the hell this is doing to my brain...

Wow, this exact thing has been happening to me. My friends think Im crazy when I tell them what I was seeing and hearing. It is really weird because If my eyes are closed I'm still seeing the room very vividly and will even take a dink of pop totally thinking it was real till I open my eyes and there is no pop can. Also I will be smoking a cigarette and open my eyes and no cigarette. So even though I'm extremely drowsy with eyes closed I see myself doing things that I'd be doing normally

 

[Mr. Tambourine Man]

So even though I'm extremely drowsy with eyes closed I see myself doing things that I'd be doing normally

THIS^ happens quite often with me, including talking to people who aren't there, on a cellphone that doesn't exist...and then hanging up after telling the caller that they don't exist...open your eyes, and you're sitting in the kitchen with empty hands.

when you take enough to make you sleepy, its almost more of a delirant quality, don't you think?

 

[negrogesic]

Why didnt the use the M1 metabolite itself, especially given its C-II (yes I know this was not the manufacturer's intention). O-demethyltramadol is far more enjoyable than tramadol, I can't even feel any relation, it is powerful, and when IV'ed (pure powder, micron filtered) it packs a hell of a punch and hits hard. Felt nothing in terms of monoamines. Tolerance grows fast, in short order I was injecting 500mg at a time. That took me to a solid nod, on the brink of dangerous respiratory depression. Felt better than the tar heroin we get around here.

 

[El_Toro]

Yeah, I noticed that at a higher dose things got REALLY weird. When I closed my eyes I would see lines of text, formatted like scripts, bulletins, etc, with fully coherent sentences (and when I say i saw the, I mean as though my eyes were open staring at the computer screen)

Sometimes there would also be voices narrating the script, and discussing meaningless scenarios, like how to build an anteater out of caramel toothpicks (no shit). Also, there were other totally random CEV's (dancing hands, collapsing balloons, and people climbing up walls, to name a few)

I would say the CEV's were on par with a 2nd+ plateau dose of DXM or a medium dose of ambien, completely photo-realistic, and VERY immersive. Of course, now I wonder what the hell this is doing to my brain...

I get the same effect from tramadol once it is converted to odesmethyl and if I am on a high dose of benzos. i believe it is the mix of mu agonism with NMDA antagonism. I can literally see real life objects when I close my eyes and engage in conversations. I am also fully narcoticised, that is, I am laying on my bed and cannot move. Mind you this only happends with 150 mgs.

Bizarrely, medium doses of pregabalin (on its own) have the same effects.

I believe morphine is also considered to produce CEV's in high enough doses as do some other opiates.

 

[Haddaway]

Yeah, I noticed that at a higher dose things got REALLY weird. When I closed my eyes I would see lines of text, formatted like scripts, bulletins, etc, with fully coherent sentences (and when I say i saw the, I mean as though my eyes were open staring at the computer screen)

Sometimes there would also be voices narrating the script, and discussing meaningless scenarios, like how to build an anteater out of caramel toothpicks (no shit). Also, there were other totally random CEV's (dancing hands, collapsing balloons, and people climbing up walls, to name a few)

I would say the CEV's were on par with a 2nd+ plateau dose of DXM or a medium dose of ambien, completely photo-realistic, and VERY immersive. Of course, now I wonder what the hell this is doing to my brain...

WOW! I just posted in another thread, and that is EXACTLY what I said. It causes CEVs EXACTLY on par with DXM (whereas youll be in a room staring at say a desk, then you close your eyes and it still looks like you're staring at a desk, and a whole bunch of other crazy shit. I love it! It feels like a great opiate and has extremely interesting hallucinogenic effects! GREAT stuff in my opinion.

 

[bicycle-ride1943]

Wow, I've been waiting for someone to mention about how "trippy" shit happens on higher doses. Wanted to make sure I wasn't losing my mind lol. For me it's mainly wavy floors and intricate patterns on things, and the ocasional tracer here and there. I've been on Nucynta since the first month it came out last June, If anyone has any questions about it drop me a PM.

 

[Mr. Tambourine Man]

Bizarrely, medium doses of pregabalin (on its own) have the same effects.

Oh my, yes...I mentioned this on another thread. On two occasions I mixed the two (say 450-600mg pregabalin and ~300mg tapentadol). The visuals caused by this combination induced were insane, to say the least. Fast moving CEV's conversations with invisible people, and OEV's that put me in an almost delirious state (one example would be seeing people carrying non-existent objects and demanding to have them, causing much confusion).

However, I don't think I could, in good faith, reccomend this combination to anyone (unless you want people to think you're truly nuts)