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Benzos Harm reduction for injecting midazolam (dormicum) users.

Tryptamite

Bluelighter
Joined
Dec 5, 2006
Messages
3,447
Location
Dublin
Midazolam is one of the few water soluble benzos that is worth shooting. Flurazepam is soluble at any ph but only really worth shooting if you mix it with heroin or similar.

The solubility of midazolam is ph dependent.

At 7.0 pH, you can only get 0.024mg per mL of water.

At 5.0 pH, you can get 1mg/mL of water. This is better but pretty bad, considering people like to shoot more than 1mg generally speaking.

At < 3.0 pH, you can get a considerably larger amount of the drug in a single mL of water, as the drug will then switch over to the open-ring form.

The pills come in white 7.5mg and blue 15mg. Obviously the blues are better for our use.

Apparently hospital vials of midazolam are very potent and 5 mg would knock you out. I have worked up to shots of 15mg and 30mg preparations from pills with tolerance for desired effects.
Obviously we are not getting all the midazolam out of the pills. Do not lower the ph below 3. This will ruin your veins.

For HR purposes we will use simple chemistry and exploit the ph characteristics to remove water soluble inactive ingredients. Litmus (ph indicator paper) is pretty much essential.
It is better to prepare many doses at once but the technique will work with just one pill.


1. Remove pill coating with alcohol swab or wet kitchen paper and allow to dry.
2. Crush pills to a fine powder and put them in a tall narrow container.
3. Add a few mls of sterile water (ph7) and mix. You are losing minuscule amounts of midazolam.
4. Allow powder to settle fully to the bottom of container.
5. Draw off most of the water without disturbing the sediment. Discard. Leave some water on top of powder to avoid losing midazolam.
A needless syringe works well for this. For taller containers fix a piece of aquarium tubing to the barrel.
Steps 3-5 can be repeated to ensure elimination of water soluble inactives.

6. Add the desired amount of water based on amount of midazolam present.
7. Add acid in small amounts, stopping to check the ph as you stir the solution (citric is perfect, white vinegar will. do, lemon juice is unhealthy).
8. Once you reach desired ph (~3) give a final stir and give a minute to settle. Yes there will still be a smaller amount of insoluble inactives left. Do not at any stage apply heat to the mixture.
9. Filter water midazolam solution through a cigarette filter and then through a micron filter. Solution should be clear, not cloudy.
10. Store in a sterile container. Start with a small dose if unused to iv midazolam.


In theory and in good practice you will have only midazolam in your solution. It has been some time since I performed this procedure but it does work and it is far nicer to your body to shoot a clear solution as opposed to the milky one you would get from just crushing the tablets and lowering the ph.

Thanks to captain heroin for his thread on benzo water solubility.
 
Good thing we get heroin base over here or I would have wasted these blues by not acidifying.

Is it true that that the 15 mg pills are better suited to Iv preparation and if so why?
 
Good thing we get heroin base over here or I would have wasted these blues by not acidifying.

Is it true that that the 15 mg pills are better suited to Iv preparation and if so why?

I wasted a lot of 7.5mg pills without adding an acid, before I knew about the ph thing.

The blue pills are better simply because they have more midazolam in them and as far as I remember they are the same size so less filler and binder to deal with.

Try preparing your heroin and midazolam separately and adding them together in 2ml if it won't fit in 1ml.

Also the fact that midazolam is going into solution after you have salted our lovely base heroin is an indication that you are using more acid than necessary. Less citric means less damage to veins.
People here cook up in foil citric packets. Each sachet is 100mg citric acid. Which is far too much for one bag of heroin. At least the heroin around here at the moment.
 
Your telling me you shoot solutions at pH 3.0 regularly?! Are you serious?

Midazolam has worked perfectly for me via the sublingual route everytime I've had dormicum. I've made the mistake of injecting midazolam multiple times and it's truly better left to the hospital setting, but that's because due to my medical conditions I require general anesthesia to work when needed, and since I respond best to a combination of fentanyl/midazolam, I don't fuck with fentanyl or midazolam.
 
Usually when I prep and the purity allows it I dissolve stuff first and then dilute to just about under 3 ml. I never measured the ph of a solution but I imagine ph 3 burns like hell.(I did a few of these shots back in the day, especially when acidifying cottons or residue). We use ascorbic instead of citric , it's a weaker acid but I rarely use more than 30 mg)

Anyway the dormicum was a holiday thing they are not available here in the Netherlands and frankly with the quality of the heroin, the rare few injectors don't need them anyway. If I were to idd probably add a smal quantity of ethanol to my solution.

Even if you weren't to take them at the hospital leaving dormicum and fent aside seems very wise to me. Both substances take you close to death routinely at the least so it appears to me.
 
Your telling me you shoot solutions at pH 3.0 regularly?! Are you serious?

No not regularly. I went through a few boxes. I used to add midazolam to my speedballs but it kind of overpowered or took away from the h and c combination.

I did say not to go below ph3.
 
Even if you weren't to take them at the hospital leaving dormicum and fent aside seems very wise to me. Both substances take you close to death routinely at the least so it appears to me.

Exactly, that's why I don't use fentanyl or midazolam outside of hospital setting anymore (I used to abuse them both via IV), it's nice knowing that the general anesthesia is going to work and that I don't have to worry about suffering anesthesia awareness because I couldn't resist abusing midazolam.

Yeah, midazolam is a great benzo, arguably the best one. It's certainly my favorite, but benzodiazepines are tools, they aren't toys. The sooner you adhere to this mindset, the sooner you'll be able to benefit from using benzodiazepines as an aid, and not a solution (no pun intended) ;)

I mean, I know the appeal of IV midazolam, but honestly if you're going through this much trouble (like injecting Dormicum at pH 3.0.......), you should take a step back and just honestly assess whether you're making the best decisions by injecting midazolam like this. You know you can get all the same effects of midazolam taken from the oral/sublingual/etc ROA???
 
well, having shot plenty of benzos as with most drugs no other ROA packs quite the punch. is that worth shooting pills for? i certainly believed so at the time, but then i didn't really give a fuck about the consequences, and now that the consequences of about 10 years of self-destruction, mostly in the form of drugs, are catching up to me, i'm starting to reassess my approach to such matters.
 
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