Half-life and Tolerance

[ThinWhiteDuke23]

I've been pondering about this for awhile. Does a drug's half-life have bearing on gaining tolerance to the substance? Example: I've read that 7.4 hours is the half-life of tramadol. From what I understand, it takes 5 times the half-life to get tramadol out of your system.

My question is: does taking the substance (tramadol in this case) while it in its half-life (in your system still) or earlier contribute to tolerance? Or does tolerance have nothing to do with that? Say you take it right after its out of your system will you gain tolerance?

Sorry if this is a stupid question.

 

[switchtop]

No, this makes perfect sense, don't apologize.
I can tell you from experience that redosing within the half life of any opiate raises the tolerance. Especially if you do it more than a couple days in a row.

 

[ThinWhiteDuke23]

No, this makes perfect sense, don't apologize.
I can tell you from experience that redosing within the half life of any opiate raises the tolerance. Especially if you do it more than a couple days in a row.

Ok, and whenever it is fully out of your system you can take more and no tolerance will develop? This stuff is interesting

 

[szuko000]

Tolerance is as mental thing as a physical change. So over a course of a defined period of time the physical changes you associate with tolerance will fade. They will also adjust to lower tolerance levels as related to blood plasma levels, so someone on a constant, lets call it 50 (drug units) in their blood, will have a higher tolerance then someone with 25 (drug units) and its probably not a linear relationship either but i dont know.

But the mental part you will not shake as easily. You will always remember a nod from a high dose by which you will judge all other experiences, even unfairly do to nostalgia.

Its not simple at all lol so questions are abundant and probably unanswered in lots of areas.