Had diazepam last night, is having alprazolam tonight safe?

[kokaino]

Neither do I. I just know that it was one of the factors in the study.

Edit: I am thinking it is because of the different affinities to the different GABA subunits which are responsible for the different properties.

Although it has no effect on the onset of effects of any benzo, but if that's the route we're going to go then alprazolam loses big time. Diazepam has more powerful effects at equal doses (0.5 mg alprazolam vs 10 mg diazepam) due to stronger affinities to more benzo receptors.

Here is a thread I made which is in the "Other Drugs Directory" - The GABA(A) Receptor Complex and Benzodiazepines

You also mentioned blood plasma. Blood plasma is nothing but the liquid component of blood that doesn't contain the blood cells. It is mostly made up of water (almost 95% ) and proteins such as albumin, immunoglobulins, lipids, glucose, minerals, vitamins, and hormones. I don't see how plasma would directly effect the onset of effect of any drug. The components of the plasma may play a role, but "plasma binding" - there's no such thing.

 

[Tommyboy]

Although it has no effect on the onset of effects of any benzo, but if that's the route we're going to go then alprazolam loses big time. Diazepam has more powerful effects at equal doses (0.5 mg alprazolam vs 10 mg diazepam) due to stronger affinities to more benzo receptors.

Here is a thread I made which is in the "Other Drugs Directory" - The GABA(A) Receptor Complex and Benzodiazepines

You also mentioned blood plasma. Blood plasma is nothing but the liquid component of blood that doesn't contain the blood cells. It is mostly made up of water (almost 95% ) and proteins such as albumin, immunoglobulins, lipids, glucose, minerals, vitamins, and hormones. I don't see how plasma would directly effect the onset of effect of any drug. The components of the plasma may play a role, but "plasma binding" - there's no such thing.

"A drug's efficiency may be affected by the degree to which it binds to the proteins within blood plasma. The less bound a drug is, the more efficiently it can traverse cell membranes or diffuse."

http://en.wikipedia.org/wiki/Plasma_protein_binding

So it may be that the diazepam effects are so subtle that it feels like it has a slower onset? I am only referring to its effects as an anxiolytic from the original conversation about panic attacks.

 

[reyqaz]

Good morning people!
I had 3 0.25's of alprax last night and i must say, the sleep was wonderful.
I am starting to feel that my tolerance is increasing and maybe i should take a break off these, use them only when i get anxiety.

and the discussion about which one hits early, its pretty much the same.
Regards
Rey

 

[purple_cloud]

Good morning people!
I had 3 0.25's of alprax last night and i must say, the sleep was wonderful.
I am starting to feel that my tolerance is increasing and maybe i should take a break off these, use them only when i get anxiety.

and the discussion about which one hits early, its pretty much the same.
Regards
Rey

I'm glad you had a wonderful sleep, but please be careful with them, I'm addicted to benzos and it's such a bitch, use them only when you need them, for the sake of harm reduction

And, I guess YMMV with this one, although alprazolam hits MUCH faster for me and I'm not actually the biggest fan of valium, my favorite benzo for daily anxiety/it helps with nausea too is lorazepam (ativan). But you don't want to get to the daily point, it's not fun when you realize the mess you're in and the hell of a withdrawal you're going to eventually have to put yourself through.

 

[reyqaz]

Thanks for your suggestion, i will be cutting down on these.

Actually i did face a bit of a withdrawal last week as the week before i used to do diaz in the daytime and night. Then i completely stopped for a week.
It w/d effects are real bad!

I'm glad you had a wonderful sleep, but please be careful with them, I'm addicted to benzos and it's such a bitch, use them only when you need them, for the sake of harm reduction

And, I guess YMMV with this one, although alprazolam hits MUCH faster for me and I'm not actually the biggest fan of valium, my favorite benzo for daily anxiety/it helps with nausea too is lorazepam (ativan). But you don't want to get to the daily point, it's not fun when you realize the mess you're in and the hell of a withdrawal you're going to eventually have to put yourself through.

 

[purple_cloud]

Thanks for your suggestion, i will be cutting down on these.

Actually i did face a bit of a withdrawal last week as the week before i used to do diaz in the daytime and night. Then i completely stopped for a week.
It w/d effects are real bad!

Yeah and you haven't seen anything, most of that was probably more mental and physical. I've read some horror stories on here, and after 3+ years of daily benzo use (usually at lower doses though, now I try to limit to 2mg ativan a day and maybe a lil helper of .5-1mg xanax or some kpin in there, just because it's an anxious point in my life) but I know it's gonna be really shitty when I have to start tapering off. You read on here about people being on them for decades, its scary shit man, it can cause seizures and kill you. Definitely avoid getting addicted to benzos, it's not cool nor fun.

 

[Z Y G G Y]

I read on here about horrid w/d after just 1 month of 3mg per day use.

No it's not just my experience, but it's based on fact. The fact that it is more lipid soluble makes it quicker acting. I think they are about equal, but I believe diazepam is quicker acting due to it being more lipid soluble.

Check out this study of diazepam vs alprazolam for panic disorder

Similar studies have found lorazepam to be just as effective as alprazolam for panic disorder. Alprazolam is not special in anyway. It's not the quickest acting benzo.

A British study conducted in 1993 and was corroborated by 2 independent Australian studies, an Irish study, and a Scandinavian study. What they did was figure out the fatal toxicity indices for each benzodiazepine (just like it was done for tricyclic antidepressants and barbiturates). The study stated that the most rapidly acting benzos which have the quickest onset are the most toxic. Temazepam was at the top with a fatal toxicity index (FTI) of 11.9. Diazepam had a 4.0, while alprazolam had a 5.9. So this study suggests that alprazolam is quicker acting because it's slightly more toxic than diazepam. As you can imagine the hypnotics took the top spots (temazepam, flunitrazepam, nitrazepam, triazolam, etc)



Well, the study above suggests that diazepam is just as effective as alprazolam for panic disorder.

Studies take an average of all the people involved. Yes, it might have been as you said for valium but for me personally if I don't wait like 3 days b/w re dosing valium I get no effects, at all almost. Why is that? I dunno. But I can re dose xanax all day and get effects.

That's what I was trying to say. I wasn't in the study. This is just my personal individual experience.

Take it for what it is. But I'm telling the truth.

 

[Z Y G G Y]

So it may be that the diazepam effects are so subtle that it feels like it has a slower onset? I am only referring to its effects as an anxiolytic from the original conversation about panic attacks.

Yes, that makes a lot of sense.

 

[reyqaz]

Yeah and you haven't seen anything, most of that was probably more mental and physical. I've read some horror stories on here, and after 3+ years of daily benzo use (usually at lower doses though, now I try to limit to 2mg ativan a day and maybe a lil helper of .5-1mg xanax or some kpin in there, just because it's an anxious point in my life) but I know it's gonna be really shitty when I have to start tapering off. You read on here about people being on them for decades, its scary shit man, it can cause seizures and kill you. Definitely avoid getting addicted to benzos, it's not cool nor fun.

NOTED!
I will be careful with these! Thanks for the insight, greatly appreciated!

 

[kokaino]

I read on here about horrid w/d after just 1 month of 3mg per day use.



Studies take an average of all the people involved. Yes, it might have been as you said for valium but for me personally if I don't wait like 3 days b/w re dosing valium I get no effects, at all almost. Why is that? I dunno. But I can re dose xanax all day and get effects.

That's what I was trying to say. I wasn't in the study. This is just my personal individual experience.

Take it for what it is. But I'm telling the truth.

That 1993 British study that was corroborated by other independent studies in Australia (2 independent studies), Ireland, and in Sweden (it's why Sweden banned temazepam). That study and the studies that followed it and corroborated it set the benzodiazepines toxicity. The fatal toxicity indices that were set are ironclad and accepted by all medical and pharmacology universities around the world. It is the study that is referred to in medical school, pharmacy school, and any pharmacology course.

However, everyone is different and maybe yes for you Xanax has a faster onset and you can redose and get effects all day - that's because it's a short-acting benzo. With diazepam, it's a long-acting benzo that has active metabolites oxazepam, temazepam, and desmethyldiazepam. Temazepam and oxazepam are quickly metabolized and eliminated, but desmethyldiazepam stays in your system for a long time and so when you redose you won't feel the effects because you're already being effected.

There is a big difference between short-acting benzo's and long-acting benzo's.

 

[kokaino]

"A drug's efficiency may be affected by the degree to which it binds to the proteins within blood plasma. The less bound a drug is, the more efficiently it can traverse cell membranes or diffuse."

http://en.wikipedia.org/wiki/Plasma_protein_binding

So it may be that the diazepam effects are so subtle that it feels like it has a slower onset? I am only referring to its effects as an anxiolytic from the original conversation about panic attacks.

Well diazepam is highly protein bound and highly lipid soluble. It crosses the BBB extremely fast through the oral route. Effects can be felt within 15 minutes. 30 minutes after ingestion full effects can be felt and it quickly reaches. Peak plasma levels is 1 - 1.5 hours. It says diazepam reaches peak plasma concentrations faster than alprazolam. The reason for that is because it is a quicker acting agent.

This information is from official FDA trials (from Rxlist.com):

After oral administration > 90% of diazepam is absorbed and the average time to achieve peak plasma concentrations is 1 - 1.5 hours with a range of 0.25 to 2.5 hours. Absorption is delayed and decreased when administered with a moderate fat meal. In the presence of food mean lag times are approximately 45 minutes as compared with 15 minutes when fasting. There is also an increase in the average time to achieve peak concentrations to about 2.5 hours in the presence of food as compared with 1.25 hours when fasting. This results in an average decrease in Cmax of 20% in addition to a 27% decrease in AUC (range 15% to 50% ) when administered with food.

Source

Following oral administration, alprazolam is readily absorbed. Peak concentrations in the plasma occur in 1 to 2 hours following administration. Plasma levels are proportionate to the dose given; over the dose range of 0.5 to 3.0 mg, peak levels of 8.0 to 37 ng/mL were observed. Using a specific assay methodology, the mean plasma elimination half-life of alprazolam has been found to be about 11.2 hours (range: 6.3-26.9 hours) in healthy adults.

Source

 

[Tommyboy]

^ Well it seems as though you are in the lower range, and I am in the higher range of time time it takes to achieve the peak plasma concentrations after administration of diazepam, and inversely with alprazolam.

 

[nicksoutherland90]

So i'm just gonna answer the OP's question....since no one else has outright done so...yes you are safe to take the meds. hell i took 90 mg of valium last night and 6 mg of xanax tonight....and i do this ona regular basis so no worries my friend have a joyous buzz!

 

[reyqaz]

Wow, that is a LOT! I'm a bit worried about the w/d you'll have to go through!

So i'm just gonna answer the OP's question....since no one else has outright done so...yes you are safe to take the meds. hell i took 90 mg of valium last night and 6 mg of xanax tonight....and i do this ona regular basis so no worries my friend have a joyous buzz!

 

[laCster]

That 1993 British study that was corroborated by other independent studies in Australia (2 independent studies), Ireland, and in Sweden (it's why Sweden banned temazepam). That study and the studies that followed it and corroborated it set the benzodiazepines toxicity. The fatal toxicity indices that were set are ironclad and accepted by all medical and pharmacology universities around the world. It is the study that is referred to in medical school, pharmacy school, and any pharmacology course.

However, everyone is different and maybe yes for you Xanax has a faster onset and you can redose and get effects all day - that's because it's a short-acting benzo. With diazepam, it's a long-acting benzo that has active metabolites oxazepam, temazepam, and desmethyldiazepam. Temazepam and oxazepam are quickly metabolized and eliminated, but desmethyldiazepam stays in your system for a long time and so when you redose you won't feel the effects because you're already being effected.

There is a big difference between short-acting benzo's and long-acting benzo's.

that's good to know! thanks for the post... i had no clue diazepam metabolized into temazepam and oxazepam...probably why i like diazepam so much 8)

 

[Violenza666]

It is shitty for panic attacks... Xanax pwwwwns diazepam as far as panic attacks go. However now that I'm not having attacks anymore I take Valium instead of Xanax.

Also Xanax kicks in faster, it's supposed too. It's a fast acting benzo made to stop a panic attack dead in it's tracks.

^ Yeah I found valium to be shitty for panic attacks because it works like one every three days. Xanax you can re dose any time.

As long as you don't take any opiates with it or other tranquilizers I think you should be fine. Just take a small dose first and see you you feel. Wait an hour and redose if needed.

I just did the same thing. Diazepam last nigtt. Zanax today with vics, But my tolerance is very high.

It all really depends on your tolerance. If its low you gotta be careful. Try to have someone with you or have your phone ready to call 911 if you have difficult breathing and keep blacking out.

 

[Mugz]

Going to close this one up now, as it seems like a lot of threads recently have ended up becoming social discussion non related to the original topic.

We do have a new Social and Information Booth Thread in BDD that would be perfect for talking about your drug use, maybe give it a look and try it out, the link is in my signature and attached to the thread name I just typed above.

If you think the thread warrants further discussion and should stay open then shoot me a PM.

Mugz