Had diazepam last night, is having alprazolam tonight safe?

[reyqaz]

Hi people,
I've been having 10mg split half Diazepams / 5mg Valiums in controlled amounts for recreational use since a month now.
Today i've got 45 alprax 0.25mg
So how many of 0.25 alprax equals a 15 mg of diazepam?

Also is it safe to have alprax tonight if i had around 15mg of diazepam last night?
Your help, as always is greatly appreciated!

Regards
Rey

 

[NeighborhoodThreat]

It is safe, take a look at the conversion chart in my signature for more information.

Approx. 0.5mg alprazolam = 10mg diazepam. So therefore, about 0.75mg alprazolam = 15mg diazepam.

However, alpraz is quicker-acting and lasts much shorter than diaze does, as you can see from the chart, so many people consider it to be a stronger benzo. It will only last 3-4 hours whereas diazepam lasts much longer.

 

[reyqaz]

Thanks a lot!
Your insights have been a lot helpful, have a great day/night.

Regards
Rey

 

[kokaino]

It is safe, take a look at the conversion chart in my signature for more information.

Approx. 0.5mg alprazolam = 10mg diazepam. So therefore, about 0.75mg alprazolam = 15mg diazepam.

However, alpraz is quicker-acting and lasts much shorter than diaze does, as you can see from the chart, so many people consider it to be a stronger benzo. It will only last 3-4 hours whereas diazepam lasts much longer.

I hate to disagree with you, but diazepam is more lipid soluble and thus has a quicker onset of effects than alprazolam does. Alprazolam is an highly potent benzo, but it's weak in terms of it's effects. It is a very powerful anxiolytic (I can testify to that as I've been on it for anxiety for 4 years), but it's a weak anticonvulsant, weak muscle relaxant, and a weak sedative. Diazepam is a much stronger sedative at equal doses (0.5 mg vs 10 mg).

 

[purple_cloud]

I hate to disagree with you, but diazepam is more lipid soluble and thus has a quicker onset of effects than alprazolam does. Alprazolam is an highly potent benzo, but it's weak in terms of it's effects. It is a very powerful anxiolytic (I can testify to that as I've been on it for anxiety for 4 years), but it's a weak anticonvulsant, weak muscle relaxant, and a weak sedative. Diazepam is a much stronger sedative at equal doses (0.5 mg vs 10 mg).

I'm just curious, but is it just in your experience that diazepam has a quicker onset? Since I've got a decent amount of benzo experience, nothing beats alprazolam for a panic attack, and IMO it comes on MUCH faster than diazepam, and many more people find alprazolam to be recreational than diazepam. Also, if it's lipid soluable, I would think it would hang around much longer with a longer halflife like diazepam does, since THC is also lipid soluable and hangs around in the body for a long time.


They pretty much make alprazolam to come on VERY VERY quickly, and diazepam to come on slower and last much longer...so I agree totally with NT on this one.

 

[Z Y G G Y]

^ Yeah I found valium to be shitty for panic attacks because it works like one every three days. Xanax you can re dose any time.

As long as you don't take any opiates with it or other tranquilizers I think you should be fine. Just take a small dose first and see you you feel. Wait an hour and redose if needed.

I just did the same thing. Diazepam last nigtt. Zanax today with vics, But my tolerance is very high.

It all really depends on your tolerance. If its low you gotta be careful. Try to have someone with you or have your phone ready to call 911 if you have difficult breathing and keep blacking out.

 

[kokaino]

I'm just curious, but is it just in your experience that diazepam has a quicker onset? Since I've got a decent amount of benzo experience, nothing beats alprazolam for a panic attack, and IMO it comes on MUCH faster than diazepam, and many more people find alprazolam to be recreational than diazepam. Also, if it's lipid soluable, I would think it would hang around much longer with a longer halflife like diazepam does, since THC is also lipid soluable and hangs around in the body for a long time.


They pretty much make alprazolam to come on VERY VERY quickly, and diazepam to come on slower and last much longer...so I agree totally with NT on this one.

No it's not just my experience, but it's based on fact. The fact that it is more lipid soluble makes it quicker acting. I think they are about equal, but I believe diazepam is quicker acting due to it being more lipid soluble.

Check out this study of diazepam vs alprazolam for panic disorder

Similar studies have found lorazepam to be just as effective as alprazolam for panic disorder. Alprazolam is not special in anyway. It's not the quickest acting benzo.

A British study conducted in 1993 and was corroborated by 2 independent Australian studies, an Irish study, and a Scandinavian study. What they did was figure out the fatal toxicity indices for each benzodiazepine (just like it was done for tricyclic antidepressants and barbiturates). The study stated that the most rapidly acting benzos which have the quickest onset are the most toxic. Temazepam was at the top with a fatal toxicity index (FTI) of 11.9. Diazepam had a 4.0, while alprazolam had a 5.9. So this study suggests that alprazolam is quicker acting because it's slightly more toxic than diazepam. As you can imagine the hypnotics took the top spots (temazepam, flunitrazepam, nitrazepam, triazolam, etc)

^ Yeah I found valium to be shitty for panic attacks because it works like one every three days. Xanax you can re dose any time.

Well, the study above suggests that diazepam is just as effective as alprazolam for panic disorder.

 

[reyqaz]

Thanks for the replies,
I just had 2 0.25mg in a span of 2.5 hours, and i think both have pretty much the same effects.
But i find, diazepam has better muscle relaxing abilities.
I try to take a week off benzos which i did and this would be my week on. I try to be as conservative in use as i can.

Thanks everyone,
Have a great time!

 

[Anon123098]

umm are my posts showing up? jw

 

[Z Y G G Y]

It is safe, take a look at the conversion chart in my signature for more information.

Approx. 0.5mg alprazolam = 10mg diazepam. So therefore, about 0.75mg alprazolam = 15mg diazepam.

However, alpraz is quicker-acting and lasts much shorter than diaze does, as you can see from the chart, so many people consider it to be a stronger benzo. It will only last 3-4 hours whereas diazepam lasts much longer.

That's the positive side of valium. It makes me kinds sickly and sleepy but pretty much makes me anxiety free for days. Xanax only last for few yours and you have to re dose if you need,

They are both very much different medications. Xanax is more in your face, take care of anxiety quickly but valium is subtle and works mildly for days. I found that after I took it I was anxiety free for like 2-3 days. I didn't really feel the effects I just felt no anxiety.

I think its harder to get addicted to diazepan than xanx encase it dose really provide a high, Whereas xanax dose.

So for those worried about dependency choose valim/clonazepan. Maybe lorazepam for bad breakthrough panic attacks, but only very sparingly.

I read on here that 3mg of xanax taken daily can lead to horrid w/d symptoms. SO be careful people. I don;t want anyone to supper so I warning you all.

Benzos for great for anxiety but once you get dependent/tolerance/addicted then what you have is your original anxiety plus the w/d from the benzo. I heard it insanely hard to go through. Better to prevent the situation than try to fix it.

I know what addiction is. It's traumatizing, If I can get at last one person to not take this shitty road it is a success for me.

I currently got off methadone and just take meds like clonidine, xanax, valium, tramadol for another 5 days. Well See how it goes.

Good luck to those at the beginning of the road. Don't think you are different that addicts. No one started to want to be an addict. If you continue you can almost e guaranteed that you;; defendant/addicted and from there the road is very very hard. Please don't make the mistakes I did. It cost me so much. Learn for my mistakes. PM me if you want more info on horrid addiction is,

 

[kokaino]

Thanks for the replies,
I just had 2 0.25mg in a span of 2.5 hours, and i think both have pretty much the same effects.
But i find, diazepam has better muscle relaxing abilities.
I try to take a week off benzos which i did and this would be my week on. I try to be as conservative in use as i can.

Thanks everyone,
Have a great time!

Diazepam is not only a better muscle relaxant, but a better anticonvulsant and a better sedative aswell.

When you have a low tolerance, alprazolam is a decent sedative, but as soon as your tolerance builds up high, forget about it. It's as weak as a placebo. I have more than 4 years experience with this drug.

 

[purple_cloud]

No it's not just my experience, but it's based on fact. The fact that it is more lipid soluble makes it quicker acting. I think they are about equal, but I believe diazepam is quicker acting due to it being more lipid soluble.

Check out this study of diazepam vs alprazolam for panic disorder

Similar studies have found lorazepam to be just as effective as alprazolam for panic disorder. Alprazolam is not special in anyway. It's not the quickest acting benzo.

A British study conducted in 1993 and was corroborated by 2 independent Australian studies, an Irish study, and a Scandinavian study. What they did was figure out the fatal toxicity indices for each benzodiazepine (just like it was done for tricyclic antidepressants and barbiturates). The study stated that the most rapidly acting benzos which have the quickest onset are the most toxic. Temazepam was at the top with a fatal toxicity index (FTI) of 11.9. Diazepam had a 4.0, while alprazolam had a 5.9. So this study suggests that alprazolam is quicker acting because it's slightly more toxic than diazepam. As you can imagine the hypnotics took the top spots (temazepam, flunitrazepam, nitrazepam, triazolam, etc)



Well, the study above suggests that diazepam is just as effective as alprazolam for panic disorder.

None of this does anything to disagree with my point, at all. Valium and Xanax were found to be just as good for panic disorder, it doesn't say which one is faster or not. Even in your own post above, you say that alprazolam is quicker acting (the part I bolded) Clearly there are other medications good for anxiety problems, my preferred benzo is lorazepam. But in terms of JUST xanax vs. diazepam, not bringing in other benzos once you realized you were wrong, xanax is quicker acting, end of story. The fact that diazepam is lipid soluable isn't mentioned in any of those citations, and while I'll take your word for it, I don't think that means it's "quicker acting" when your own sources say that alprazolam is.

 

[Tommyboy]

Well, the study above suggests that diazepam is just as effective as alprazolam for panic disorder.

The results indicate that diazepam is an effective alternative to alprazolam for the treatment of panic disorder

http://www.ncbi.nlm.nih.gov/pubmed/8752017

That is not the same as just as effective. Also, the patients were given either drug over a period of eight weeks. It would seem that the long half-life of the diazepam would help prevent some of the panic attacks from occurring for some of the individuals. A lot of people that get panic attacks don't want to be on a benzo daily, so they are prescribed the alprazolam to be taken as needed. This is why doctors prescribe diazepam for GAD, with alprazolam to be taken as needed for panic attacks. It is similar to and ER drug being prescribed with an IR drug for breakthrough pain, but in this case, breakthrough anxiety.

I agree that the qualities of diazepam are far greater than that of alprazolam, but would disagree in regards to the onset. I found the onset of alprazolam to be a lot quicker than that of diazepam. I was on alprazolam for 5 years, and diazepam for 18 months to give you an idea of my experience.

 

[kokaino]

None of this does anything to disagree with my point, at all. Valium and Xanax were found to be just as good for panic disorder, it doesn't say which one is faster or not. Even in your own post above, you say that alprazolam is quicker acting (the part I bolded) Clearly there are other medications good for anxiety problems, my preferred benzo is lorazepam. But in terms of JUST xanax vs. diazepam, not bringing in other benzos once you realized you were wrong, xanax is quicker acting, end of story. The fact that diazepam is lipid soluable isn't mentioned in any of those citations, and while I'll take your word for it, I don't think that means it's "quicker acting" when your own sources say that alprazolam is.

I said my source suggests that because it is more rapidly acting and thus more toxic. But I think because diazepam is more lipid soluble, it is quicker acting. It's usually that way. In either case, they are both about the same. If one kicks in within 25 minutes and the other kicks in 3 minutes later, what's the big deal?

Choose a BZP with an onset of action that matches the patient's circumstances. For acute control of anxiety or agitation rapid onset is required. Lorazepam, diazepam and alprazolam are all relatively quick acting. However, lorazepam is recommended due to its moderate duration of effect and low risk for accumulation. Diazepam's onset is very rapid and for some it is associated with a euphoriant effect which has been linked to its heightened abuse potential. Alprazolam, though quick in onset is also quick in offset and once treatment with alprazolam is established it can be particularly difficult to discontinue. For this reason alone, we suggest avoiding alprazolam altogether.

http://www.theberries.ca/botw_archives/benzodiazepines.html

 

[purple_cloud]

I said my source suggests that because it is more rapidly acting and thus more toxic. But I think because diazepam is more lipid soluble, it is quicker acting. It's usually that way. In either case, they are both about the same. If one kicks in within 25 minutes and the other kicks in 3 minutes later, what's the big deal?

I don't think it "suggests" that at all. What's the big deal?! You've never had a panic attack in your life then. 3 minutes and 25 minutes is a HUGE deal when you feel like you are going to die/have a heart attack/can't breathe.

 

[kokaino]

I don't think it "suggests" that at all. What's the big deal?! You've never had a panic attack in your life then. 3 minutes and 25 minutes is a HUGE deal when you feel like you are going to die/have a heart attack/can't breathe.

I've had plenty of panic attacks and I'm on alprazolam. I believe diazepam would've been just as quick, if not quicker in killing my panic attacks. We are just going to have to agree to disagree here. Diazepam's pharmacokinetics say it is more rapidly acting.

 

[Tommyboy]

I've had plenty of panic attacks and I'm on alprazolam. I believe diazepam would've been just as quick, if not quicker in killing my panic attacks. We are just going to have to agree to disagree here. Diazepam's pharmacokinetics say it is more rapidly acting.

I would think that plasma binding and affinity receptor binding would also be factors for the rates of onset, so lipid solubility is not the only factor.

I have been on both alprazolam and diazepam, and found alprazolam to be better for panic attacks.

We can agree to disagree on our preference as to which works better for panic attacks, but I wouldn't say that diazepams pharmacokinetics prove that it is more rapidy acting just based on lipid solubility.

 

[kokaino]

I would think that plasma binding and affinity receptor binding would also be factors for the rates of onset, so lipid solubility is not the only factor.

I have been on both alprazolam and diazepam, and found alprazolam to be better for panic attacks.

We can agree to disagree on our preference as to which works better for panic attacks, but I wouldn't say that diazepams pharmacokinetics prove that it is more rapidy acting just based on lipid solubility.

There's a lot of research behind diazepam being the quickest acting of the common anxiolytics. I just don't have the time to go and look and try to dig out research papers over something so trivial. But I don't understand just exactly how affinity receptor binding would be a factor?

 

[Tommyboy]

There's a lot of research behind diazepam being the quickest acting of the common anxiolytics. I just don't have the time to go and look and try to dig out research papers over something so trivial. But I don't understand just exactly how affinity receptor binding would be a factor?

Neither do I. I just know that it was one of the factors in the study.

Edit: I am thinking it is because of the different affinities to the different GABA subunits which are responsible for the different properties.

 

[Escapedysphoria]

Diazepam is not only a better muscle relaxant, but a better anticonvulsant and a better sedative aswell.

When you have a low tolerance, alprazolam is a decent sedative, but as soon as your tolerance builds up high, forget about it. It's as weak as a placebo. I have more than 4 years experience with this drug.

I completely agree with kokaino. I was prescribed 1.5mg clonazepam and 1mg alprazolam for about a year and I was switched over to 10mg diazepam and 2mg diazepam (take as needed) and found that I felt a mildly euphoric buzz from taking one 10mg diazepam sublingually despite that 0.5 of alprazolam is equivalent to 10mg of diazepam. In comparison, I would take my 1mg alprazolam and expirience nothing but relief of my anxiety and benzo withdrawals. The properties of diazepam obviously make it more sedating and the muscle relaxation is very prominent.