Benzos Grapefruit Juice Potentiation

[optimuswind]

Potentiation (Juice) and other questions.

Has there been any formal study or test on this? For example I have many questions and all the google results for this come up with about a million different answers.

1. Do you gain a tolerance to the potentiation effect? (Or would a tolerance increase be attributed to the benzos themselves?)

2. Will it accellerate the rate at which you gain tolerance to the anxiolytic effects (if you even do, I have read differing things on this too)

3. How much? How long before eating the pill?

4. As I understand it, it does something in your gut which reduces the amount of enzymes or something, so there are less of them to absorb the benzo, and thusly allow more into your bloodstream. Based on that, how long does the potentiation last after drinking the juice? How long is it before your gut gets back to normal etc?

5. Will storing the benzos in too hot or too cold an enviroment cause them to lose any of their effectiveness or anything? what is the best way to store them, or does it not matter?

Thanks in advance if anyone can answer these. Oh and specifically whether or not you can completely build up a total tolerance to the anxiolytic effects and then eating 50 pills won't do anything for anxiety (but will put you to sleep for 2 days of course, because you don't develop a tolerance to those effects nearly as much..)

 

[optimuswind]

Nobody know anything about the pharmokinetics of this stuff then?

 

[tricomb]

Use the search engine first please. If you had even used google, you could have found dozens of peer reviewed articles about the pharmacokinetics on benzodiazepine and attempts to "potentiate" them. For the most part, the consensus is that grapefruit juice may extend the duration of some benzodiazepines, or at least I've heard reports of this, but I think the vast majority would agree with me in saying no, GFJ does not significantly potentiate benzodiazepines.

I don't think benzodiazepines can, should, or even would need to be potentiated so long as you take the proper dose....

http://www.bluelight.ru/vb/threads/...diazepines?p=10914982&viewfull=1#post10914982

Here's a source backing up my claims that GFJ has no significant effect in potentiating alprazolam.

The effects of repeated ingestion of grapefruit juice, an inhibitor of cytochrome P450 3A4 (CYP3A4), on the pharmacokinetics and pharmacodynamics of both single and multiple oral doses of alprazolam, a substrate of CYP3A4, were examined. In study 1, eight healthy volunteers ingesting 600 ml/day water or grapefruit juice for 10 days took a single oral 0.8-mg dose of alprazolam on the eighth day. Plasma drug concentrations were monitored up to 48 h after alprazolam dosing together with evaluation of psychomotor function. Grapefruit juice altered neither the plasma concentrations of alprazolam at any time points, any pharmacokinetic parameters, nor the majority of psychomotor function parameters in subjects. In study 2, 11 patients with anxiety disorders receiving alprazolam (0.8-2.4 mg/day) ingested grapefruit juice (600 ml/day) for 7 days. Blood samples were collected before and during grapefruit juice ingestion and 1 week after its discontinuation together with an assessment of clinical status. Grapefruit juice altered neither the steady-state plasma concentration of alprazolam nor the clinical status in patients. The present study shows that grapefruit juice is unlikely to affect pharmacokinetics or pharmacodynamics of alprazolam due to its high bioavailability.

 

[optimuswind]

Ok thanks for that. so it *may* increase duration, but probably not? anything else that was missed?

thanks again

 

[Mr.Scagnattie]

This has been talked about to death.. all of these questions have been answered in 100 separate threads.

UTFSE.