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grapefruit juice and hydrocodone

gethigh said:
one test i just did online 142 :P
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If you actually think that an online IQ test gives you a real IQ score, then trust me...your IQ is WAY below average. Those tests area intentionally easy and the score is fake. Contact Mensa and take the standardized test for your real score. My god man...I'm just shaking my head here.
 
btw considering ive been out of school almost all my high school (all of sophmore cept a few weeks, 3 quarrters of junior year and half of this year so far) i havnt had many hard classes and chem isnt on the act
 
^
Yeah that site is wrong, OverDriven. As far as hydrocodone, I read a paper that said it's debatable, or to be more specific, more studies need to be done. But, I think I've also read a paper about hydrocodone being administered to EM's and PM's, and there was no difference. That would imply that it is not a prodrug.

From what I've read, I don't think it's a prodrug.

Actually, oxycodone has a fairly decent affinity for the mu receptor without having to be metabolized to oxymorphone, although obviously any oxymorphone produced is going to increase the opiate effect
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I've read a study that compared EM's and PM's use of oyxcodone, as well as using 2D6 inhibitors and inducers. Although hydromorphone levels were higher, no subjective difference was noted among the participants.
 
Er no. Cimetidine (Tagamet) also inhibits other cytochrome P450 enzymes, one of which (CYP2D6) is responsible for converting codeine/dihydrocodine etc to the corresponding morphine compound by removing the O-methyl group. You want something that only inhibits CYP3A4 which is responsible for converting codeine/morphine derivatives to the corresponding norcodeine/normorphine by removing the N-methyl group.

Man I have read all over BL where it does potentiate. So once and for all, does it or doesn't it????
 
what i said in my first big post about the noroxy/hydrocodone being useless, and to hold off that conversion as long as possible potentiates, as i said before, oxy/hydrocodone themself work as well does their minor metabolite oxy/hydromorphone, but still it took me a while to learn that.
 
you want to hold off the conversion from oxy/hydrocodone to noroxy/hydrocodone, as the noroxy/hydrocodone is useless, oxy/hydrocodone it self and its minor metabolite oxy/hydromorphone create the high. but im not good enough to know what enzymes do what, but the mod said it.
 
Bottom line: Cimetidine significantly prolongs the duration but possibly moderately reduces the intensity of hydrocodone and oxycodone induced intoxication. It must me ingested one hour prior to said opioids and every two hours post ingestion for continual CYP450 inhibition. Grapefruit juice serves a dual pupose of inhibiting cytochrome P450 AND P-glycoprotein which is responsible for the encephalic clearance via chemical efflux. If GP juice and Cimetidine is coingested, the former must be deacidified by antacids to prevent the destruction of the latter. Excrutiatingly simple, not much reason to discuss this any further.
 
Forgot to mention, both Hydrocodone and Oxycodone used to be considered prodrugs by general scientific consensus, however upon emergence of further research data it was concluded that they are both indeed active on their own and their respective metabolites provide negligible effects. The original assumption was most likely stemmed from the fact that codeine is a prodrug of morphine and as such is inactive on its own hence the hydro and oxy moeities of codeine were assumed to be also inactive prior to their enzymatic transformation to their respective morphones, again this assumption however logical is simply erroneous. Assumption is mother of all errors.
 
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theanine said:
Forgot to mention, both Hydrocodone and Oxycodone used to be considered prodrugs be general scientific consensus, however upon further emergence of research data it was concluded that they are both indeed active on their own and their respective metabolites provide negligible effects. The original assumption was most likely stemmed from the fact that codeine is a prodrug of morphine and as such is inactive on its own hence the hydro and oxy moeities of codeine were assumed to be also inactive prior to their enzymatic transformation to their respective morphones, again this assumption however logical is simply erroneous. Assumption is mother of all errors.
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Over my head haha
 
Or to use the paraphrase from 'Lock, Stock & Two Smoking Barrels':-

Assumption is the mother of all fuck-ups!


I still want to know if I get the lollipop & gold star? =D


It's spealled Mesna, foo'.
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It's actually mensa - Latin for table (but why a table relates to geniuses is completely beyond me - guess that buggers my chances with them straight off =D)
 
fastandbulbous said:
It's actually mensa - Latin for table (but why a table relates to geniuses is completely beyond me - guess that buggers my chances with them straight off =D)
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Yeah,
taht was my joke.

:( :\ ;)

Table cause all the smart meet
& sit at one,
an' talk about
how dumb every one else is.
Methinks.
​

PEACE BRO
UnS
:)
 
can someone link to the thread with all the assorted potentiators and their corresponding opiate?
 
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