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grapefruit juice and hydrocodone

so will the grapefruit juicework with hydrocodone or just with oxy? i'm very uninformed about any of this so thanks for your patience in answerin my questions
 
i read on opioids.com that there are only 2 metabolites of hydro/oxycodone, being hydro/oxymorphone and norhydro/oxycodone, respectively of course.
 
gethigh said:
thats what i said, the ratio of conversion to noroxy/hydrocodone is much larger than that which is converted to oxy/hydromorphone.
which is why i said the main effects are from oxy/hydrocodone it self.
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Oxycodone is converted to noroxycodone and oxymorphone. I think you're confusing your oxy's and hydro's.
 
gethigh said:
wats that for? and can i have my mom get it at somewhere like walmart?
and is it true about white vs pink grapefruit juice?
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Why are you going to have your mom buy it for you? There is no age restriction on cimetidine or GF juice.
 
gethigh said:
norhydrocodone is hydrocodone's useless metabolite, the main acting metabolite is hydromorphone and hydrocodone itself, so if it inhibits turning it into norhydrocodone it will increase duration, i believe that it is what is passed in the urine.
same dance for oxycodone, it has two major metabolites, noroxycodone and oxymorphone, same as above noroxycodone is useless and oxymorphone is 10x more potent than oxycodone, but it is a minor metabolite, as it is in a much smaller ratio, the same with hydrocodone and hydromorphone, smaller ratio of oxycodone to oxymorphone, and the ratio of oxycodone to noroxycodone is much larger than the conversion to oxymorphone.
hope that makes sense.
a small portion of oxy/hydrocodone is metabolized into oxy/hydromorphone, compared to the much larger amount metabolized into noroxy/hydrocodone, which is useless for analgesia or recreational value.
so by increasing the time it takes it to convert the oxy/hydrocodone into noroxy/hydrocodone, the longer the high/pain relief lasts.
make sense?
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where the fuck did you steal that bit of info from???


no fucking way you wrote that not much of a chance that you even understand that judgeing from your other posts


give me a break all the sudden you get this flash of pharmacological knowledge
when you started into this thread you did not know what tagemet was


its ok to cut and paste but you should not try to take credit for it
 
so how much white grapefruit should i drink and when should i drink it. also would it be a waste to do a cwe for just #4 10/650 hydro's? and also what effects do you have when you do a cwe on hydro compared to just takin the pills intact? just tell me guys if just sound stupid in askin these questions.i've very new to all this and very uninformed about this type of stuff
 
how much grapefruit juice?
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1 to 2 pints should do the trick. Drink it 30-45 minutes before dosing.

should I CWE 4 of these pills?
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That's 2.6g of APAP. If you don't take much APAP, you don't have to cwe them. Anything more than 4g may cause liver damage.

effects of cwe to taking the pills regularly?
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When you do a cwe you're drinking a liquid, so onset would be quicker than just swallowing intact pills. But, keep in mind that you lose active product when you do a cwe.

If you're worried about onset time, just crush up the pills and parachute.



Also, if you do 4, you'll be doing 40mg of hydrocodone. If you don't have an opiate tolerance, that can make you sick. I'd do just two in that case.







also what are prodrugs?
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Do a search or use Google. I'm logging off.
 
bc I stay in bed all day so I don't have to have any more pain than normal
 
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I seriously wrote that myself from research I did on my own, I swear, I scored a 160 on my iq test last year. I'm dead serious.
I swear to god, opiates are my specialty. Google what i wrote, it shouldn't come up nowhere but here.
Johnnyb420 hating on me again. I swear to god (that also hates me too) that i wrote that myself.
Also, I'm very clear minded now, I just got out of the shower, haven't been high in about 3 days I think.
 
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No actually if I wanted to take my time when I post I would sound intelligent, like no spelling or grammar errors in this post?
 
I swear to god that I thoroughly research all my medicines that I take, Wikipedia, is my homepage, no joke. :)
 
I don't think I'd admit about not wanting to take time when you post to sound intelligent. Especially on a highly research based site like this.

Not many drugs act as prodrugs, but some do. The new one, Vynase or lisdexamfetamine is one, as is desoxyphenobarbital (an unscheduled pheno analogue) some opioids are- like codeine, and in some ways so is diacetylmorphine.

All that an enzyme inhibitor is going to do for a drug like hydrocodeinone or oxycodeinone will be the extention of the halflife and peak plasma concentrations.

Since it will be metabolized much slower, what's absorbed at first will (mostly) still be there when the peak plasma levels are reached- this means that when peak plasma concentrations are reached, much of the initially absorbed drug will still be there- because it isn't being metabolized- those concentrations will be higher.

And so will you. Plus, because it'll disapear more slowly, it'll last longer.

There's no reason, as far as I'm concerned, to take Tagamet and grapefruit juice. There's only so much reduction in your enzymes that can be had. I think 600mg of cimetidine is enough to more or less stop their action entirely.

Hammilton
 
Do u think I copied and pasted that?
I'll admit that I learned about the metabolites from many websites, there was a thread on pharmer.org that I was active in (username caseyn08), I learned some from opioids.com, thatspoppycock.com but I certainly did not copy and paste that.
 
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It does as I'm getting bright flight scholarship into college from scoring 32 on act, well at least my pretest say I will do that good, I haven't taken it yet, but I'm taking it soon, I have the act packet in my drawer. Also I think it was exceptionally gifted was what I got, and it was a 167 actually.
 
Do I? No, not verbatim. I do think you probably just read an opioids.com website and copied what you read there as you recalled it.

Your general level of intelligence as shown by what you write here just isn't that high. You don't sound all that intelligent based on what you've written.

And what was the IQ test you took? a WISC test? An online test? What? Who administered it? That makes a huge difference.

I took the WISC-III when I was in high school, and scored a 140 or a 150, I really can't recall. I was told that had I not been depressed during the 2nd half of it, I'd likely have scored 10 points higher.

I don't put a lot of stock into those numbers though. I was accepted into Columbia and UCLA (wait listed on the latter, though) before I became mentally ill and ended up barely making it into a state school.

Numbers just don't mean a whole lot in the long run.

edit: don't put too much stock into what a pretest says you'll do. Mine said I'd have gotten a 35, but I ended up not sleeping for 2 days and having some other psychiatric problems on the day of the test only did a 29. Composite score, that is. I did score a 36 on a section, I think writing.
 
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