Glycine NMDA antagonists

[Kantros]

Hi, sorry for the lack of clarity in the last topic.

I was interested if there are any compounds that offer relatively selective glycine NMDA antagonism.
What are the mechanisms by which they affect mood and what systems do they affect?
Are there other drugs that will enhance these effects on mood and brain functioning?


GLYX-13 is an NMDA antagonist I have been reading about.

Furthermore, does anyone have concrete information in mechanism of action for tianeptine?

By the way, I am not looking for treatment for myself, I am a doctor working in the Philippines.
I have a patient that I treated successfully but he has had a relapse. I was hoping to put the topic in personal terms so as people would better understand. I don't mean to intimidate anyone, even though I am a professional I find public internet forums like this one have a great deal of information available.

 

[CaptainCook]

The most popular NMDA receptor antagonist that comes to my mind right off the bat would be Phencyclidine, but I highly doubt any respectable physician would prescribe a patient such a potent dissociative. First thing you need to address, if you can, is what might you be treating your patient for ? As you probably already know NMDA receptors play a large role in long term potentiation and synaptic plasticity, so maybe it's safe to assume that it could possibly be Alzheimer's, CTE or any degenerative disease related to it. If the latter is the case you might have interest in Memantine which is a primarily Glutamatergic uncompetitive NMDA receptor antagonist. In studies, Memantine has also shown serotonergic antagonistic activity which may inadvertently prove to act as a anxiolytic as well. I will post an article that may prove to be useful in the case of memantine that is.

http://www.ncbi.nlm.nih.gov/pubmed/12672860

 

[Toz]

I got a prescription for some antihistamine/nmda antagonist just let me remember the name...

Orphenadrine, there. I think it's selective for glycine as well actually but I could be wrong.

 

[nAON]

I haven't heard about them being used clinically much, just experimental pharmacology. Though I imagine Glycine antagonists would produce the same side effects as an NMDA antagonist such as ketamine.

Hadn't heard of GLYX13 before but just did a few minutes reading but it seems interesting, gonnd do some more reading on it :D