I had good success treating depression with tianeptine several years ago, but need some augmentation strategies at the present.
There is an article called "NMDA and AMPA receptors are involved in the activity of tianeptine in the forced swim test in mice."
L-701,324, a glycine site NMDA antagonist boosted the effects of tianepine.
I am looking for a glycine site NMDA antagonist, it doesn't matter if it is weak as I am mainly looking for something to augment tianeptine.
I know GLYX-13 is an NMDA antagonist and is in development, but other more available options would be nice.
Are there any such compounds available (herbs, pharms, research, etc.)?
(also, sildenafil boosts brain concentrations of tianeptine so that may be another option).
Perhaps augmenting with something with a different mechanism than tianeptine would help? But from my experience, my depression is extremely treatment resistant and only responded to tianeptine and its effects on the glutamate system.
There is an article called "NMDA and AMPA receptors are involved in the activity of tianeptine in the forced swim test in mice."
L-701,324, a glycine site NMDA antagonist boosted the effects of tianepine.
I am looking for a glycine site NMDA antagonist, it doesn't matter if it is weak as I am mainly looking for something to augment tianeptine.
I know GLYX-13 is an NMDA antagonist and is in development, but other more available options would be nice.
Are there any such compounds available (herbs, pharms, research, etc.)?
(also, sildenafil boosts brain concentrations of tianeptine so that may be another option).
Perhaps augmenting with something with a different mechanism than tianeptine would help? But from my experience, my depression is extremely treatment resistant and only responded to tianeptine and its effects on the glutamate system.
