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Glutamic Acid & B6 to boost Pregabalin

Charles Ferdinand

Charles Ferdinand

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Apr 29, 2009
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Hi!
First of all, will Glutamic Acid (as found in common food supplements) will cross the blood-brain barrier.
If it does, then, combined with some niacin (the cofactor) should (as I think) help boost Pregabalin (Lyrica) effects.
Pregabalin is known to convert Glutamic acid into GABA in one step, as well as being mentioned as a GABA analogue.
Would that work?, I'm I totally wrong? What do you think?
Thanks in advance!
Regards!
 
Except the glutamic acid will end up saturating the active L-amino-acid transport in the gut which also happens to transport gabapentin (and, I assume, pregabalin - correct me if I'm wrong). Since I believe (and again, correct me if I'm wrong) glutamic acid has the highest affinity for this transport, you'll be getting glutamate and much less pregabalin than you would have by taking it on its own.

Supplementing glutamic acid in hopes of raising GABA production only works for people who are seriously malnourished (think Africa poster children). And even if you DID make more gaba, the problem is not the scarcity of gaba, but rather the down regulation of receptors.
 
I still don't see the point in supplementing with glutamic acid at any time. It is one of the most abundant amino-acids in food. That's why I said it only does anything IF you're SO malnourished you have more pressing issues to worry about than GABA. A regular meal should have more glutamic acid than you'd ever need.

It seems to be best to take lyrica on empty stomach, *especially* if you had a protein-rich meal.
 
so the prevalence of glutamic acid in food is likely the reason why pregabalin has such a delayed onset when taken in close temporal proximity to a meal?
 
Glutamic as well as other amino acids. I am pretty sure I read somewhere that L-Theanine is also transported that way so avoid green/heavy black teas also.
 
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