(Gilenya/Fingolimod) 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol Interaction's

[ANDO420]

Hello everyone

My girlfriend has Primary-progressive multiple sclerosis (PPMS) and has recently started a study in witch she is taking 1 Fingolimod 0.5mg capsule a day.

We usually indulge in some weekend fun every few weekends, mostly MDMA and other stimulants like speed, coke etc. I have done a heap of searching with no luck.


My question is what bad interactions can anyone see with taking fingolimod (2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol) with MDMA (3,4-methylenedioxy-methamphetamine) or speed ( S,S)-2-methylamino-1-phenylpropan-1-ol)


Some links to Fingolimod info:

https://www.pharma.us.novartis.com/product/pi/pdf/gilenya.pdf

https://en.wikipedia.org/wiki/Fingolimod

http://www.chemspider.com/Chemical-Structure.97086.html

https://www.nlm.nih.gov/medlineplus/druginfo/meds/a611006.html


Any help would be fantastic! I wasn't sure where to put this, figured this would be the best bet to get someone who would be able to look at the technical info and have an idea how it would interact

 

[Dresden]

0.5mg doesn't sound like a lot, but hey, I don't know. However, there is no "-ol " suffix in speed. I really don't see why there would be a problem with it, unless it's some kind of freak interaction.

 

[belligerent drunk]

0.5mg doesn't sound like a lot, but hey, I don't know. However, there is no "-ol " suffix in speed. I really don't see why there would be a problem with it, unless it's some kind of freak interaction.

S,S)-2-methylamino-1-phenylpropan-1-ol sounds like ephedrine to me. But yeah, I don't see why it would cause some kind of an interaction.

 

[sekio]

If you are doing a study of a new drug, don't go out taking recreational drugs, it could invalidate the results of the study or make the medication not work.

 

[aced126]

If you are doing a study of a new drug, don't go out taking recreational drugs, it could invalidate the results of the study or make the medication not work.

Agreed, or tell them you are doing so (unlikely). In this case I can't really see any way in which the results could be altered; as far as I know amphetamine or MDMA won't significantly interact with multiple sclerosis or fingolimod itself but nevertheless there is that possibility which could alter the perceived efficacy of fingolimod.

Even more so, they are more likely to interact pharmacokinetically and these drugs might well alter the half life of fingolimod. This would interfere with the study if they were recording this kind of data.

 

[clubcard]

Hi,
My (slightly) older sister has MS. I looked into Fingolimod. It seems that it has acute side-effects. I looked into studies and the people who suffered the initial side-effects went one to suffer opportunistic infections. Right now she's on Interferon beta 1a and every month, she get's thrush after her period. Every month for 6 months! I think she's quite rightly scared that swapping to something else could be worse. Of course, there are a LOT of unpublished papers on Fingolimod which means they could cherry pick the trials that went well while HIDING the other studies.

If you haven't already signed it, most of the organic chemistry periodicals asked for people to vote on making ALL trial data available. But then again, do you know HOW good a new drug has to be to be legally acceptable? Better than nothing. Seriously, they NEVER compare their drug with real equivalent, only against a placebo. In a meta-analysis of 274 trials on ALL of the antidepressants available in the US and do you know what won? What worked for more people and worked better than the SSRIs? Clomipramine!

For those of you who have to PAY for their medicines, cloripramine or (close second) amitriptyline. They cost pennies here in the UK.. In the US they are likely to cost 10% of a new SNDRI or ANYTHING for which their isn't a generic and you TELL the doctor you want the generic. I mean, you're PAYING to see the doctor so you should be able to ask. Next day you feel better (you sleep REALLY well) and, for so many people, poor sleep patterns and nightmares lead to unrefreshing sleep. You have to stay away from uppers (possible seizure) and downers (alcohol, barbs, benzos & clomethiazole) mixed with the tricyclics can kill you.