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GABOB / Gamalate

Reminisant B

Reminisant B

Greenlighter
Joined
Nov 3, 2005
Messages
401
Strange chemical, hadn't seen this one before (appeared on erowid) yet a google search brings up a number of nutritional suppliers selling it.

(No wikipedia entry for it! how mad 8) )

GABA with hydroxy group on.

Anyone have any other info on it?
 

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well, bough a couple packs of 'gamalate b6' several years ago..
didn't do much for me, even taking several (like 5-10) i could hardly feel it.. but. ymmv..
 
^why?

that would make GABA surely.

Anyway please don't include synth in this discussion, I have already had two threads closed due to ppl delving straight in to synth discussions.

Was hoping to find any more pharmacological info on the compound
 
Reminisant B said:
^why?

that would make GABA surely.

Anyway please don't include synth in this discussion, I have already had two threads closed due to ppl delving straight in to synth discussions.

Was hoping to find any more pharmacological info on the compound
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Yeah, oops - looking at the wrong group/molecule. Looking further, I see it wouldn't serve that purpose anyhow. But I won't say any more, because I don't want to fuck your thread over. Nowadays, it seems I just assume thats where all threads are leading anyway. ;)
Sorry 'bout that bud.
 
johanneschimpo said:
Yeah, oops - looking at the wrong group/molecule. Looking further, I see it wouldn't serve that purpose anyhow. But I won't say any more, because I don't want to fuck your thread over. Nowadays, it seems I just assume thats where all threads are leading anyway. ;)
Sorry 'bout that bud.
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No worries, cheers, would happily discuss but rules are rules I guess. :)
 
Well it doesn't seem to be a strong sedative, but it might chill you out a bit.

Probably more of a mildly relaxing effect like theanine or something rather than GHB.
 
I have already had two threads closed due to ppl delving straight in to synth discussions.
Click to expand...

Sorry! Thought vague discussion was ok and basically just commented on Shulgins synth to say its a difficult substitution pattern :\
 
dorothyperkins said:
Sorry! Thought vague discussion was ok and basically just commented on Shulgins synth to say its a difficult substitution pattern :\
Click to expand...

Yeah no worries, what got said before thread being closed was really interesting anyway, cheers. :)

Enough was said to clear up the question in my mind as to why demethoxy-bromo-mescaline hasn't been investigated.
 
Will definitely update when I try it.

Apparently GABOB is one of the few known "GABA-C" (or GABA-ρ, whatever). This article discusses the presence of these receptors in the retina.

Recent studies on ganglion cell responses reveal some interesting features of GABAc receptors in retinal information processing. For example, activation of GABAc receptors leads to more transient light responses in ganglion cells (Dong and Werblin, 1998) and the delayed inhibition mediated by GABAc receptors is thought to play a major role in shaping edge-enhancement of ganglion cell receptive fields (Jacobs and Werblin, 1998). The bipolar cell to ganglion cell synapse is probably heavily influenced by inhibitory amacrine feed forward or feedback synapses and these appear to be via primarily GABAc receptors.
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It would be tempting to imagine that taking a GABA-C agonist would affect vision somehow, but one is quickly reminded that the retina contains all three types of GABA receptors and that common gabaergics don't have any perceptible effects on vision.

I admit that I understand very little of the pharmacology of GABA receptors - an insanely confusing subject. If anyone with a more thorough understanding can shed more light (in English ;)) on this receptor type, I'd be very interested.
 
it's been reported with other classes of drugs, but GABAergic depressants always caused blue flashing in the periphery of my vision, particularly when it was dark outside. or inside.
 
I wonder....could activation of rho-subunit homomer type GABAa (aka GABAc) be responsible for ocular toxicity of vigabatrin? or is there some other mechanism. It is known to cause atrophy of the optic nerves.

Is there any such activity reported with longterm use of muscimol? (if such reports even exist...never heard tell of a fly agaric addict :p)
 
^ Interesting idea. I, too, was wondering about muscimol....

Also, is the benzo-caused change in intraocular pressure related to to GABA or is it through any other mechanism?

Ham: Hmm, can't say I ever noticed the like...
 
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